SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1izc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 1izc MACROPHOMATE
SYNTHASE
INTERMOLECULAR
DIELS-ALDERASE
(Macrophoma
commelinae) 		4 / 6 SER A 111
HIS A  86
THR A 112
ARG A  78
 None
 1.33A 3thrB-1izcA:
0.7		 3thrB-1izcA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_L_CLML221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1izc MACROPHOMATE
SYNTHASE
INTERMOLECULAR
DIELS-ALDERASE
(Macrophoma
commelinae) 		5 / 12 PHE A 149
THR A 173
SER A 174
TYR A 141
SER A 162
 None
 1.46A 3u9fJ-1izcA:
0.0
3u9fL-1izcA:
0.0		 3u9fJ-1izcA:
23.03
3u9fL-1izcA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1izc MACROPHOMATE
SYNTHASE
INTERMOLECULAR
DIELS-ALDERASE
(Macrophoma
commelinae) 		5 / 11 THR A 173
SER A 174
TYR A 141
SER A 162
PHE A 149
 None
 1.41A 3u9fN-1izcA:
0.0
3u9fO-1izcA:
0.0		 3u9fN-1izcA:
23.03
3u9fO-1izcA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 1izc MACROPHOMATE
SYNTHASE
INTERMOLECULAR
DIELS-ALDERASE
(Macrophoma
commelinae) 		5 / 11 CYH A 179
ILE A  99
LEU A  32
ALA A  31
LEU A  43
 None
 1.09A 4p65E-1izcA:
undetectable
4p65F-1izcA:
undetectable
4p65J-1izcA:
undetectable
4p65L-1izcA:
undetectable		 4p65E-1izcA:
5.39
4p65F-1izcA:
8.30
4p65J-1izcA:
8.30
4p65L-1izcA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 1izc MACROPHOMATE
SYNTHASE
INTERMOLECULAR
DIELS-ALDERASE
(Macrophoma
commelinae) 		4 / 7 PHE A  76
ILE A  69
GLY A  49
THR A  53
 None
 1.14A 4zxiA-1izcA:
undetectable		 4zxiA-1izcA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 1izc MACROPHOMATE
SYNTHASE
INTERMOLECULAR
DIELS-ALDERASE
(Macrophoma
commelinae) 		5 / 12 VAL A 122
LEU A  28
PHE A  66
LEU A  43
THR A  42
 None
 1.34A 5hnxB-1izcA:
2.6		 5hnxB-1izcA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1izc MACROPHOMATE
SYNTHASE
INTERMOLECULAR
DIELS-ALDERASE
(Macrophoma
commelinae) 		5 / 12 THR A  23
GLY A  26
TYR A  24
ALA A  31
ALA A 119
 None
 1.20A 5kvaB-1izcA:
undetectable		 5kvaB-1izcA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1izc MACROPHOMATE
SYNTHASE
INTERMOLECULAR
DIELS-ALDERASE
(Macrophoma
commelinae) 		5 / 12 ALA A  84
PRO A  51
GLY A  74
LYS A  57
ALA A  88
 None
 1.30A 5zvgA-1izcA:
undetectable		 5zvgA-1izcA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1izc MACROPHOMATE
SYNTHASE
INTERMOLECULAR
DIELS-ALDERASE
(Macrophoma
commelinae) 		5 / 12 ALA A  84
PRO A  51
GLY A  74
LYS A  57
ALA A  88
 None
 1.29A 5zvgB-1izcA:
undetectable		 5zvgB-1izcA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 1izc MACROPHOMATE
SYNTHASE
INTERMOLECULAR
DIELS-ALDERASE
(Macrophoma
commelinae) 		5 / 10 ASN A 246
HIS A 203
ALA A 197
GLU A 201
ILE A 181
 None
 1.15A 6bniA-1izcA:
undetectable		 6bniA-1izcA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 1izc MACROPHOMATE
SYNTHASE
INTERMOLECULAR
DIELS-ALDERASE
(Macrophoma
commelinae) 		5 / 10 ASN A 246
HIS A 203
ALA A 197
GLU A 201
ILE A 181
 None
 1.15A 6bniB-1izcA:
undetectable		 6bniB-1izcA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 1izc MACROPHOMATE
SYNTHASE
INTERMOLECULAR
DIELS-ALDERASE
(Macrophoma
commelinae) 		4 / 7 GLN A  30
GLY A 204
PHE A 251
VAL A 248
 None
 0.84A 6ekzA-1izcA:
0.0		 6ekzA-1izcA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 1izc MACROPHOMATE
SYNTHASE
INTERMOLECULAR
DIELS-ALDERASE
(Macrophoma
commelinae) 		3 / 3 TRP A  68
ILE A  69
ASP A  70
 None
 0.69A 6i0y7-1izcA:
undetectable		 6i0y7-1izcA:
5.75