SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ize'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 12 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.16A 1hvyA-1izeA:
0.0		 1hvyA-1izeA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 12 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.17A 1hvyB-1izeA:
0.0		 1hvyB-1izeA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 11 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.13A 1hvyC-1izeA:
0.0		 1hvyC-1izeA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 9 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.20A 1i00A-1izeA:
undetectable		 1i00A-1izeA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 9 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.19A 1i00B-1izeA:
undetectable		 1i00B-1izeA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 8 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.16A 1rtsA-1izeA:
0.0		 1rtsA-1izeA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 7 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.18A 1rtsB-1izeA:
undetectable		 1rtsB-1izeA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		4 / 6 SER A 128
ILE A 129
ALA A 125
ALA A 312
 None
 0.87A 1w0gA-1izeA:
0.0		 1w0gA-1izeA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 9 LEU A 157
ASP A 300
ILE A 212
GLY A  35
VAL A 155
 None
 1.01A 2avoA-1izeA:
6.5		 2avoA-1izeA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		6 / 12 PHE A  42
GLY A  29
ASP A  26
ASN A 118
LEU A  30
LEU A 122
 None
 1.43A 2nxeA-1izeA:
undetectable		 2nxeA-1izeA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		3 / 3 ASP A  38
THR A  46
PRO A  47
 None
 0.63A 2pynB-1izeA:
6.6		 2pynB-1izeA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		3 / 3 ASP A  38
THR A  46
PRO A  47
 None
 0.64A 2qakB-1izeA:
6.6		 2qakB-1izeA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 7 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.16A 2tsrA-1izeA:
0.0		 2tsrA-1izeA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 8 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.13A 2tsrB-1izeA:
undetectable		 2tsrB-1izeA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 10 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.11A 2tsrC-1izeA:
0.0		 2tsrC-1izeA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 9 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.18A 2tsrD-1izeA:
0.0		 2tsrD-1izeA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		6 / 12 ASP A  33
GLY A  35
SER A  36
TYR A  75
ASP A 214
GLY A 216
 None
 0.33A 2v0zC-1izeA:
38.0		 2v0zC-1izeA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		6 / 12 THR A 170
ILE A 152
GLY A   4
THR A   3
GLY A 168
THR A  19
 None
None
MAN  A1001 (-4.0A)
MAN  A1001 (-2.4A)
None
None
 1.34A 2y7hB-1izeA:
undetectable		 2y7hB-1izeA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		6 / 12 THR A 170
ILE A 152
GLY A   4
THR A   3
GLY A 168
THR A  19
 None
None
MAN  A1001 (-4.0A)
MAN  A1001 (-2.4A)
None
None
 1.34A 2y7hC-1izeA:
undetectable		 2y7hC-1izeA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 12 ASP A 214
GLY A 216
PHE A 295
LEU A 121
ASP A  33
 None
 1.27A 3d91A-1izeA:
38.2		 3d91A-1izeA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 10 THR A 139
ASP A 142
LYS A 145
ILE A 129
SER A  36
 None
 1.34A 3kpbD-1izeA:
undetectable		 3kpbD-1izeA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 10 TYR A 165
THR A 215
LEU A 122
GLY A 123
THR A 139
 None
 1.06A 3lxiA-1izeA:
undetectable		 3lxiA-1izeA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 11 TYR A 165
THR A 215
LEU A 122
GLY A 123
THR A 139
 None
 1.07A 3lxiB-1izeA:
undetectable		 3lxiB-1izeA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 10 LEU A 219
ASP A 223
ILE A 226
GLY A 211
ILE A 212
 None
 0.99A 3ogqA-1izeA:
8.3		 3ogqA-1izeA:
14.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		7 / 10 ILE A  73
TYR A  75
LEU A 121
THR A 131
ILE A 212
THR A 218
ILE A 293
 None
 0.43A 3prsA-1izeA:
49.9		 3prsA-1izeA:
58.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 12 ASP A  14
ASP A  33
GLY A  35
PHE A 190
ASP A 214
 None
 1.14A 3prsA-1izeA:
49.9		 3prsA-1izeA:
58.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		10 / 12 ASP A  31
ASP A  33
GLY A  35
GLY A  76
ASP A  77
ASP A 115
PHE A 190
ASP A 214
THR A 217
ILE A 297
 None
 0.39A 3prsA-1izeA:
49.9		 3prsA-1izeA:
58.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		9 / 12 ASP A  31
ASP A  33
GLY A  76
PHE A 112
LEU A 121
PHE A 190
ILE A 212
THR A 217
ILE A 297
 None
 0.39A 3pwwA-1izeA:
49.8		 3pwwA-1izeA:
58.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		6 / 12 ILE A  18
ASP A  31
PHE A 112
PHE A 190
ILE A 212
ILE A 297
 None
 1.43A 3pwwA-1izeA:
49.8		 3pwwA-1izeA:
58.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		8 / 8 GLY A  35
SER A  36
ILE A  73
TYR A  75
ASP A  77
SER A  79
ASP A 214
THR A 218
 None
 0.45A 3pwwA-1izeA:
49.8		 3pwwA-1izeA:
58.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		6 / 12 ASP A  33
GLY A  35
GLY A  76
ASP A 214
THR A 217
ILE A 297
 None
 0.26A 3q70A-1izeA:
12.8		 3q70A-1izeA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		6 / 12 ILE A 212
ASP A 214
GLY A 216
ILE A 293
GLU A  16
ASP A  33
 None
 0.79A 3q70A-1izeA:
12.8		 3q70A-1izeA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		4 / 6 SER A  36
ILE A  73
TYR A  75
THR A 218
 None
 0.24A 3q70A-1izeA:
12.8		 3q70A-1izeA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 12 TYR A 230
GLY A 285
ALA A 237
ASP A 240
PHE A 284
 None
 1.32A 3qowA-1izeA:
undetectable		 3qowA-1izeA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 12 LEU A 219
ASP A 223
ILE A 209
GLY A 211
ILE A 212
 None
 0.85A 3so9B-1izeA:
6.5		 3so9B-1izeA:
16.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		8 / 12 ASP A  33
GLY A  35
ILE A  73
GLY A  76
ASP A  77
SER A  79
ASP A 214
ILE A 297
 None
 0.32A 3tneA-1izeA:
35.8		 3tneA-1izeA:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		4 / 6 SER A  36
TYR A  75
THR A 217
THR A 218
 None
 0.17A 3tneA-1izeA:
35.8		 3tneA-1izeA:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		8 / 12 ASP A  33
GLY A  35
ILE A  73
GLY A  76
ASP A  77
SER A  79
ASP A 214
ILE A 297
 None
 0.30A 3tneB-1izeA:
35.9		 3tneB-1izeA:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		4 / 7 SER A  36
TYR A  75
THR A 217
THR A 218
 None
 0.23A 3tneB-1izeA:
35.9		 3tneB-1izeA:
30.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		4 / 5 SER A 104
GLY A  83
TRP A  40
ASP A  38
 None
 1.15A 3w9tB-1izeA:
0.0		 3w9tB-1izeA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		4 / 5 SER A 104
GLY A  83
TRP A  40
ASP A  38
 None
 1.15A 3w9tC-1izeA:
0.0		 3w9tC-1izeA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		4 / 5 SER A 104
GLY A  83
TRP A  40
ASP A  38
 None
 1.16A 3w9tD-1izeA:
0.0		 3w9tD-1izeA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 11 ALA A 266
LEU A 219
GLY A 299
ILE A 273
VAL A 308
 None
 1.04A 3zosA-1izeA:
0.0
3zosB-1izeA:
0.0		 3zosA-1izeA:
22.13
3zosB-1izeA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 11 VAL A 268
LEU A 219
GLY A 299
ILE A 273
VAL A 308
 None
 1.05A 3zosA-1izeA:
0.0
3zosB-1izeA:
0.0		 3zosA-1izeA:
22.13
3zosB-1izeA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 9 TYR A 165
THR A 215
LEU A 122
GLY A 123
THR A 139
 None
 1.13A 4c9kA-1izeA:
undetectable		 4c9kA-1izeA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 12 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.16A 4eb4A-1izeA:
undetectable		 4eb4A-1izeA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 12 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.17A 4eb4B-1izeA:
undetectable		 4eb4B-1izeA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 9 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.14A 4eb4C-1izeA:
undetectable		 4eb4C-1izeA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 10 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.17A 4eb4D-1izeA:
0.0		 4eb4D-1izeA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		4 / 8 GLY A  60
GLY A  24
VAL A 102
TYR A  86
 None
 0.91A 4fgzA-1izeA:
undetectable		 4fgzA-1izeA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 7 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.19A 4iqqA-1izeA:
undetectable		 4iqqA-1izeA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 7 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.20A 4iqqB-1izeA:
0.0		 4iqqB-1izeA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 7 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.13A 4iqqC-1izeA:
0.0		 4iqqC-1izeA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 8 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.16A 4iqqD-1izeA:
undetectable		 4iqqD-1izeA:
22.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Y4J_A_LNRA412_1
(ENDOTHIAPEPSIN)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		8 / 9 ASP A  31
ASP A  33
TYR A  75
ASP A  77
SER A  79
PHE A 112
ASP A 115
LEU A 121
 None
 0.40A 4y4jA-1izeA:
50.0		 4y4jA-1izeA:
58.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Y4J_A_LNRA412_1
(ENDOTHIAPEPSIN)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 9 ASP A  33
ASP A  77
SER A  79
PHE A 112
LEU A 121
 None
 1.44A 4y4jA-1izeA:
50.0		 4y4jA-1izeA:
58.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Y4J_A_LNRA412_1
(ENDOTHIAPEPSIN)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		6 / 9 ASP A  33
TYR A  75
SER A  79
SER A 109
PHE A 112
LEU A 121
 None
 1.44A 4y4jA-1izeA:
50.0		 4y4jA-1izeA:
58.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		4 / 5 ASN A 118
SER A  36
ASP A  77
GLU A 111
 None
 1.48A 4zjlA-1izeA:
0.4		 4zjlA-1izeA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		4 / 6 PHE A  32
SER A  36
LEU A 121
LEU A  30
 None
 1.32A 5dzke-1izeA:
0.0
5dzks-1izeA:
undetectable		 5dzke-1izeA:
20.11
5dzks-1izeA:
0.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		4 / 8 PHE A 298
GLY A 299
THR A 194
TYR A 198
 None
 0.96A 5flcB-1izeA:
undetectable		 5flcB-1izeA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		4 / 8 PHE A 298
GLY A 299
THR A 194
TYR A 198
 None
 0.96A 5flcF-1izeA:
undetectable		 5flcF-1izeA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		4 / 7 ASP A 300
GLY A 299
PHE A 298
TYR A  17
 None
 0.72A 5h3aA-1izeA:
0.0		 5h3aA-1izeA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 7 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.20A 5h3aB-1izeA:
0.0		 5h3aB-1izeA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		3 / 3 THR A 210
PRO A 315
ARG A 316
 None
 0.86A 5nd7B-1izeA:
undetectable		 5nd7B-1izeA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 7 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.20A 5nooA-1izeA:
0.0		 5nooA-1izeA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 7 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.17A 5nooB-1izeA:
undetectable		 5nooB-1izeA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 6 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.16A 5nooC-1izeA:
undetectable		 5nooC-1izeA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 8 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.19A 5nooD-1izeA:
undetectable		 5nooD-1izeA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		4 / 6 PHE A 126
LEU A 124
TRP A 191
GLY A  35
 None
 0.92A 5o4yA-1izeA:
undetectable		 5o4yA-1izeA:
3.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		4 / 6 PHE A 126
LEU A 124
TRP A 191
GLY A  35
 None
 1.10A 5o4yF-1izeA:
undetectable		 5o4yF-1izeA:
3.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 12 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.17A 5x5qB-1izeA:
0.0		 5x5qB-1izeA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 7 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.16A 5x5qC-1izeA:
undetectable		 5x5qC-1izeA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 8 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.16A 5x5qD-1izeA:
undetectable		 5x5qD-1izeA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 8 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.17A 5x5qF-1izeA:
0.0		 5x5qF-1izeA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 9 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.32A 5x66C-1izeA:
undetectable		 5x66C-1izeA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 12 GLY A 123
GLY A 120
ASN A 130
ASP A 142
ASP A  33
 None
 1.39A 5yn6A-1izeA:
undetectable		 5yn6A-1izeA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		3 / 3 ALA A 101
VAL A 144
TYR A  97
 None
 0.64A 5zmqH-1izeA:
undetectable		 5zmqH-1izeA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		5 / 11 THR A 267
GLY A 201
ILE A 200
ILE A 287
ILE A 273
 None
 0.90A 6ebzC-1izeA:
undetectable		 6ebzC-1izeA:
12.46