SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1izo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		3 / 3 MET A  97
LEU A 100
SER A 101
 None
 0.56A 1ee2A-1izoA:
undetectable		 1ee2A-1izoA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		4 / 6 TRP A 126
VAL A 123
ILE A 384
LEU A 251
 None
 1.27A 1j96A-1izoA:
undetectable		 1j96A-1izoA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		3 / 3 LEU A 100
HIS A  92
ILE A  84
 None
HEM  A 501 (-3.9A)
HEM  A 501 (-4.3A)
 0.63A 1s9pB-1izoA:
0.0		 1s9pB-1izoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		3 / 3 PHE A 253
TYR A  22
TYR A 319
 None
 1.06A 1x70B-1izoA:
undetectable		 1x70B-1izoA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_B_CHDB2_0
(LIVER
CARBOXYLESTERASE 1)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		3 / 3 TRP A 328
LYS A  26
PRO A 331
 None
 1.18A 2dqyB-1izoA:
undetectable		 2dqyB-1izoA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		3 / 3 ARG A 144
ASP A 164
ASP A 171
 None
 0.75A 2ejtA-1izoA:
undetectable		 2ejtA-1izoA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		5 / 9 LEU A 251
LEU A 377
LEU A 258
ALA A 257
PHE A 279
 None
 1.24A 2vcvD-1izoA:
undetectable		 2vcvD-1izoA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		3 / 3 HIS A 220
GLU A 216
HIS A 215
 None
 0.87A 3ba0A-1izoA:
undetectable		 3ba0A-1izoA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		5 / 12 GLY A 211
SER A 210
LEU A 102
ALA A 233
HIS A 220
 None
 1.27A 3ou7C-1izoA:
undetectable		 3ou7C-1izoA:
23.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		4 / 5 LEU A  78
ARG A 242
PRO A 243
ALA A 246
 PAM  A 601 ( 4.7A)
PAM  A 601 (-3.7A)
PAM  A 601 (-3.9A)
PAM  A 601 (-3.9A)
 0.31A 3vm4A-1izoA:
59.0		 3vm4A-1izoA:
43.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		4 / 7 ASP A 317
PHE A 292
GLY A 290
THR A 321
 None
PAM  A 601 (-4.9A)
PAM  A 601 ( 4.0A)
None
 1.04A 3vnsA-1izoA:
undetectable		 3vnsA-1izoA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		3 / 3 TYR A 249
ARG A 399
SER A 402
 None
 0.90A 4dr2I-1izoA:
0.0
4dr2J-1izoA:
undetectable		 4dr2I-1izoA:
17.22
4dr2J-1izoA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		3 / 3 TYR A 249
ARG A 399
SER A 402
 None
 0.87A 4lf7I-1izoA:
0.3
4lf7J-1izoA:
undetectable		 4lf7I-1izoA:
17.22
4lf7J-1izoA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		3 / 3 TYR A 249
ARG A 399
SER A 402
 None
 0.87A 4lf8I-1izoA:
0.3
4lf8J-1izoA:
undetectable		 4lf8I-1izoA:
17.22
4lf8J-1izoA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_B_ERYB501_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		5 / 11 TRP A 193
PHE A 166
ILE A 244
ALA A 246
SER A 248
 None
None
HEM  A 501 ( 4.7A)
PAM  A 601 (-3.9A)
None
 1.44A 4m83B-1izoA:
undetectable		 4m83B-1izoA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		5 / 12 LEU A 241
LEU A 102
LEU A 214
ALA A 218
ILE A 198
 None
 1.05A 4o2bB-1izoA:
undetectable		 4o2bB-1izoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		5 / 12 ASN A 239
LEU A 111
ALA A 213
MET A 217
GLY A 365
 None
None
None
None
HEM  A 501 ( 3.7A)
 1.29A 4qckA-1izoA:
undetectable		 4qckA-1izoA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		5 / 12 LEU A 241
LEU A 102
LEU A 214
ALA A 218
ILE A 198
 None
 1.06A 4x1iD-1izoA:
undetectable		 4x1iD-1izoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		5 / 12 LEU A 241
LEU A 102
LEU A 214
ALA A 218
ILE A 198
 None
 1.01A 4x1yD-1izoA:
undetectable		 4x1yD-1izoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		5 / 11 LEU A 241
LEU A 102
LEU A 214
ALA A 218
ILE A 198
 None
 1.07A 4x20D-1izoA:
undetectable		 4x20D-1izoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		5 / 12 LEU A 102
VAL A 240
ILE A 194
LEU A 241
MET A 217
 None
HEM  A 501 (-4.5A)
None
None
None
 1.10A 4y0qA-1izoA:
undetectable		 4y0qA-1izoA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		5 / 12 LEU A 241
LEU A 102
LEU A 214
ALA A 218
ILE A 198
 None
 1.06A 5itzB-1izoA:
undetectable		 5itzB-1izoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		4 / 6 PHE A 301
VAL A 297
MET A  49
ILE A  47
 None
 1.05A 5iwuA-1izoA:
0.0		 5iwuA-1izoA:
23.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		5 / 10 LEU A  78
ARG A 242
PRO A 243
ALA A 246
PHE A 289
 PAM  A 601 ( 4.7A)
PAM  A 601 (-3.7A)
PAM  A 601 (-3.9A)
PAM  A 601 (-3.9A)
HEM  A 501 ( 4.0A)
 0.30A 5m0oA-1izoA:
57.6		 5m0oA-1izoA:
42.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		5 / 10 LEU A  78
PHE A 173
ARG A 242
PRO A 243
ALA A 246
 PAM  A 601 ( 4.7A)
PAM  A 601 ( 4.2A)
PAM  A 601 (-3.7A)
PAM  A 601 (-3.9A)
PAM  A 601 (-3.9A)
 0.65A 5m0oA-1izoA:
57.6		 5m0oA-1izoA:
42.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		5 / 8 LEU A  78
ARG A 242
PRO A 243
ALA A 246
PHE A 289
 PAM  A 601 ( 4.7A)
PAM  A 601 (-3.7A)
PAM  A 601 (-3.9A)
PAM  A 601 (-3.9A)
HEM  A 501 ( 4.0A)
 0.31A 5m0oC-1izoA:
56.5		 5m0oC-1izoA:
41.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		5 / 8 LEU A  78
PHE A 173
ARG A 242
PRO A 243
ALA A 246
 PAM  A 601 ( 4.7A)
PAM  A 601 ( 4.2A)
PAM  A 601 (-3.7A)
PAM  A 601 (-3.9A)
PAM  A 601 (-3.9A)
 0.66A 5m0oC-1izoA:
56.5		 5m0oC-1izoA:
41.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		5 / 12 LEU A 241
LEU A 102
LEU A 214
ALA A 218
ILE A 198
 None
 1.07A 5mioB-1izoA:
undetectable		 5mioB-1izoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		5 / 12 SER A 406
GLN A 391
LEU A 134
VAL A 133
ASP A 130
 None
 1.06A 6bxmA-1izoA:
undetectable		 6bxmA-1izoA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		3 / 3 TRP A 119
GLU A 118
GLU A 137
 None
 0.90A 6fhwA-1izoA:
undetectable		 6fhwA-1izoA:
12.43