SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1j05'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 1j05 ANTI-CEA MAB T84.66,
HEAVY CHAIN
ANTI-CEA MAB T84.66,
LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 7 GLN H   6
SER H   7
TYR H  90
GLN L  38
 None
 1.48A 1eiiA-1j05H:
0.0		 1eiiA-1j05H:
20.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 1j05 ANTI-CEA MAB T84.66,
HEAVY CHAIN
ANTI-CEA MAB T84.66,
LIGHT CHAIN
(Mus
musculus) 		6 / 12 TYR L  36
GLN L  89
PHE L  98
VAL H  37
ALA H  93
TRP H 103
 None
 0.48A 1h8sA-1j05L:
21.4		 1h8sA-1j05L:
53.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		 1j05 ANTI-CEA MAB T84.66,
HEAVY CHAIN
ANTI-CEA MAB T84.66,
LIGHT CHAIN
(Mus
musculus) 		5 / 12 MET H 101
GLY H 104
GLN H   6
GLN L  89
LEU H  45
 None
 1.43A 1p93C-1j05H:
undetectable		 1p93C-1j05H:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 1j05 ANTI-CEA MAB T84.66,
HEAVY CHAIN
ANTI-CEA MAB T84.66,
LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		5 / 12 ILE L  48
GLN L   6
TYR L  86
GLN H  39
LEU H  45
 None
 1.26A 4qztA-1j05L:
0.0		 4qztA-1j05L:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1j05 ANTI-CEA MAB T84.66,
HEAVY CHAIN
ANTI-CEA MAB T84.66,
LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		5 / 12 VAL H  99
TYR H 101
ILE L  58
ILE L  48
ASN L  53
 None
 1.38A 4xueA-1j05H:
undetectable		 4xueA-1j05H:
17.59