SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1j08'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 1j08 GLUTAREDOXIN-LIKE
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 LEU A  26
ILE A  84
VAL A  93
PHE A  17
LEU A  44
 None
 1.26A 1wsvA-1j08A:
undetectable		 1wsvA-1j08A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 1j08 GLUTAREDOXIN-LIKE
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 LEU A  26
ILE A  84
VAL A  93
PHE A  17
LEU A  44
 None
 1.25A 1wsvB-1j08A:
undetectable		 1wsvB-1j08A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1j08 GLUTAREDOXIN-LIKE
PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 PHE A 159
MET A 155
ILE A 198
VAL A 136
 None
 1.10A 3p6hA-1j08A:
undetectable		 3p6hA-1j08A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 1j08 GLUTAREDOXIN-LIKE
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ILE A  84
ASP A 110
GLY A 101
LEU A  44
ILE A 179
 None
 1.10A 3pwwA-1j08A:
undetectable		 3pwwA-1j08A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1j08 GLUTAREDOXIN-LIKE
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 LYS A 215
ALA A 156
ILE A 171
LYS A 158
ILE A 138
 None
 1.15A 3ut5B-1j08A:
undetectable		 3ut5B-1j08A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5V_C_ACTC510_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1j08 GLUTAREDOXIN-LIKE
PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 THR A 119
ASP A 118
LYS A 126
GLU A 162
 None
 1.33A 3v5vC-1j08A:
0.0
3v5vD-1j08A:
0.0		 3v5vC-1j08A:
20.76
3v5vD-1j08A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_B_ACTB502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1j08 GLUTAREDOXIN-LIKE
PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 LYS A 126
GLU A 162
THR A 119
ASP A 118
 None
 1.34A 4e7cA-1j08A:
0.0
4e7cB-1j08A:
0.0		 4e7cA-1j08A:
20.76
4e7cB-1j08A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1j08 GLUTAREDOXIN-LIKE
PROTEIN
(Pyrococcus
horikoshii) 		5 / 8 ILE A 111
VAL A 114
VAL A 136
ILE A 198
ILE A 140
 None
 1.48A 5hi2A-1j08A:
undetectable		 5hi2A-1j08A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1j08 GLUTAREDOXIN-LIKE
PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 LYS A 126
ASP A 124
ILE A 171
 None
 0.90A 5kc4E-1j08A:
undetectable		 5kc4E-1j08A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 1j08 GLUTAREDOXIN-LIKE
PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 TYR A 181
LEU A 139
ASP A 204
 None
 0.72A 5zv2B-1j08A:
undetectable		 5zv2B-1j08A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1j08 GLUTAREDOXIN-LIKE
PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 ALA A 152
ARG A 154
MET A 155
ASP A 120
 None
 1.03A 6hu9m-1j08A:
0.0
6hu9q-1j08A:
undetectable		 6hu9m-1j08A:
18.15
6hu9q-1j08A:
20.37