SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1j0a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 8 GLY A 213
LEU A 227
SER A 199
GLY A 193
 None
None
None
PLP  A 401 (-3.6A)
 0.76A 1d0vA-1j0aA:
undetectable		 1d0vA-1j0aA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 8 LEU A  89
GLY A 310
ILE A 311
VAL A  86
 None
PLP  A 401 (-3.6A)
None
None
 0.77A 1d4sB-1j0aA:
undetectable		 1d4sB-1j0aA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 6 LEU A  94
ALA A  90
LEU A  96
THR A  87
 None
 0.93A 1ictB-1j0aA:
undetectable		 1ictB-1j0aA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 8 GLY A 213
LEU A 227
SER A 199
GLY A 193
 None
None
None
PLP  A 401 (-3.6A)
 0.75A 1jhaA-1j0aA:
2.4		 1jhaA-1j0aA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 8 GLY A 213
LEU A 227
SER A 199
GLY A 193
 None
None
None
PLP  A 401 (-3.6A)
 0.75A 1jhqA-1j0aA:
2.7		 1jhqA-1j0aA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K4T_D_TTCD990_1
(DNA TOPOISOMERASE I)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 5 GLU A  16
ARG A  56
LYS A  41
ASP A  43
 IPA  A1747 ( 4.1A)
None
None
None
 1.48A 1k4tA-1j0aA:
0.0		 1k4tA-1j0aA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		5 / 12 GLU A 138
ILE A  74
PRO A 151
ASP A  71
ILE A  99
 None
 1.40A 1kijA-1j0aA:
undetectable		 1kijA-1j0aA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A  55
LEU A  61
GLY A  51
GLY A  52
ASN A 111
 None
 1.02A 1likA-1j0aA:
2.5		 1likA-1j0aA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		5 / 12 TYR A 282
GLY A 157
GLY A  77
SER A  81
HIS A  80
 PLP  A 401 ( 3.6A)
SO4  A 701 ( 3.7A)
SO4  A 701 ( 4.4A)
SO4  A 701 (-2.3A)
None
 1.27A 1nbiC-1j0aA:
3.2		 1nbiC-1j0aA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		5 / 12 TYR A 282
GLY A 157
GLY A  77
SER A  81
HIS A  80
 PLP  A 401 ( 3.6A)
SO4  A 701 ( 3.7A)
SO4  A 701 ( 4.4A)
SO4  A 701 (-2.3A)
None
 1.28A 1nbiD-1j0aA:
3.3		 1nbiD-1j0aA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 304
ALA A 215
PHE A 219
ALA A 189
LEU A 198
 None
None
None
PLP  A 401 (-4.6A)
None
 1.29A 1rbpA-1j0aA:
0.0		 1rbpA-1j0aA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A  30
LEU A  27
ARG A 268
LEU A 278
 None
 1.01A 1v54N-1j0aA:
0.0
1v54W-1j0aA:
0.0		 1v54N-1j0aA:
20.99
1v54W-1j0aA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 6 LEU A 100
GLY A  88
ILE A 154
HIS A  83
 None
 0.97A 1yajF-1j0aA:
0.9		 1yajF-1j0aA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A  30
LEU A  27
ARG A 268
LEU A 278
 None
 0.98A 2dyrN-1j0aA:
0.0
2dyrW-1j0aA:
0.0		 2dyrN-1j0aA:
20.99
2dyrW-1j0aA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A  89
GLY A  47
GLY A 309
ILE A 311
VAL A  86
 None
None
PLP  A 401 (-3.9A)
None
None
 0.92A 2ieoB-1j0aA:
undetectable		 2ieoB-1j0aA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A  89
GLY A  47
GLY A 309
ILE A 311
VAL A  86
 None
None
PLP  A 401 (-3.9A)
None
None
 0.93A 2nnkB-1j0aA:
undetectable		 2nnkB-1j0aA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 5 ALA A  84
ALA A 137
ALA A 141
VAL A  72
 None
 0.92A 2nyrB-1j0aA:
undetectable		 2nyrB-1j0aA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 6 LEU A 198
TYR A 167
ILE A 174
ILE A 306
 None
 0.82A 2q8hA-1j0aA:
0.0		 2q8hA-1j0aA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 5 LEU A 321
GLY A 261
ILE A 266
ILE A 267
 None
 0.87A 2q9rA-1j0aA:
0.0		 2q9rA-1j0aA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 6 LEU A  94
ALA A  90
LEU A  96
THR A  87
 None
 0.99A 2roxB-1j0aA:
undetectable		 2roxB-1j0aA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A 165
ALA A 235
GLY A 239
PHE A  12
 None
 0.98A 2wq5A-1j0aA:
0.0		 2wq5A-1j0aA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		3 / 3 TYR A 251
GLU A 247
ASP A 208
 None
 0.67A 3bxoA-1j0aA:
2.5		 3bxoA-1j0aA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		3 / 3 TYR A 251
GLU A 247
ASP A 208
 None
 0.74A 3bxoB-1j0aA:
3.4		 3bxoB-1j0aA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A  94
ALA A  90
LEU A  96
THR A  87
 None
 0.82A 3cfqA-1j0aA:
undetectable
3cfqB-1j0aA:
undetectable		 3cfqA-1j0aA:
18.12
3cfqB-1j0aA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A  94
ALA A  90
LEU A  96
THR A  87
 None
 0.86A 3d2tA-1j0aA:
undetectable		 3d2tA-1j0aA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A  89
GLY A  47
GLY A 309
ILE A 311
VAL A  86
 None
None
PLP  A 401 (-3.9A)
None
None
 0.96A 3gguA-1j0aA:
undetectable		 3gguA-1j0aA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		5 / 10 TYR A 251
PHE A 253
VAL A 263
ILE A 266
ILE A  34
 None
 1.29A 3ihzA-1j0aA:
undetectable		 3ihzA-1j0aA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 311
GLY A 310
ASP A 279
PRO A 280
PHE A 315
 None
PLP  A 401 (-3.6A)
PLP  A 401 ( 4.2A)
None
None
 0.90A 3jb1A-1j0aA:
2.4		 3jb1A-1j0aA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A  88
ALA A  90
GLY A  49
ILE A  50
LEU A  58
 None
 0.95A 3ogpA-1j0aA:
undetectable		 3ogpA-1j0aA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A  88
ALA A  90
GLY A  49
ILE A  50
LEU A  58
 None
 0.97A 3ogpB-1j0aA:
undetectable		 3ogpB-1j0aA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		3 / 3 GLY A 190
GLY A 192
THR A 194
 PLP  A 401 (-3.6A)
PLP  A 401 (-3.7A)
PLP  A 401 (-3.8A)
 0.29A 3si7B-1j0aA:
undetectable		 3si7B-1j0aA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 4 LEU A 195
GLY A 213
LEU A 248
GLU A 247
 None
 1.00A 3tgvB-1j0aA:
undetectable		 3tgvB-1j0aA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A  89
GLY A  47
GLY A 309
ILE A 311
VAL A  86
 None
None
PLP  A 401 (-3.9A)
None
None
 0.96A 3ucbA-1j0aA:
undetectable		 3ucbA-1j0aA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A  89
GLY A  47
GLY A 309
ILE A 311
VAL A  86
 None
None
PLP  A 401 (-3.9A)
None
None
 1.00A 3ucbB-1j0aA:
undetectable		 3ucbB-1j0aA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 6 LEU A  94
ALA A  90
LEU A  96
THR A  87
 None
 0.86A 4d7bB-1j0aA:
undetectable		 4d7bB-1j0aA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A  94
ALA A  90
LEU A  96
THR A  87
 None
 0.80A 4d7bA-1j0aA:
undetectable		 4d7bA-1j0aA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A  89
ALA A  90
LEU A  17
ILE A  18
GLY A 166
 None
 0.88A 4dm8B-1j0aA:
undetectable		 4dm8B-1j0aA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		3 / 3 LYS A 109
ILE A 117
THR A 122
 None
 0.87A 4gh8A-1j0aA:
undetectable		 4gh8A-1j0aA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 6 LEU A  94
ALA A  90
LEU A  96
THR A  87
 None
 0.94A 4i89A-1j0aA:
undetectable		 4i89A-1j0aA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 6 LEU A  94
ALA A  90
LEU A  96
THR A  87
 None
 0.90A 4ikiB-1j0aA:
undetectable		 4ikiB-1j0aA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A  94
ALA A  90
LEU A  96
THR A  87
 None
 0.92A 4ikjA-1j0aA:
undetectable
4ikjB-1j0aA:
undetectable		 4ikjA-1j0aA:
19.46
4ikjB-1j0aA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 8 LEU A  94
ALA A  90
LEU A  96
THR A  87
 None
 0.88A 4ikjA-1j0aA:
undetectable
4ikjB-1j0aA:
undetectable		 4ikjA-1j0aA:
19.46
4ikjB-1j0aA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 8 LEU A  94
ALA A  90
LEU A  96
THR A  87
 None
 0.88A 4ikkA-1j0aA:
undetectable
4ikkB-1j0aA:
undetectable		 4ikkA-1j0aA:
19.46
4ikkB-1j0aA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A  94
ALA A  90
LEU A  96
THR A  87
 None
 0.89A 4ikkA-1j0aA:
undetectable
4ikkB-1j0aA:
undetectable		 4ikkA-1j0aA:
19.46
4ikkB-1j0aA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		5 / 12 TYR A 282
PHE A  85
GLY A 313
GLY A 310
ILE A 259
 PLP  A 401 ( 3.6A)
None
None
PLP  A 401 (-3.6A)
None
 1.08A 4krhB-1j0aA:
2.2		 4krhB-1j0aA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA302_1
(CHITOSANASE)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 5 THR A  22
THR A  46
ASP A  43
TYR A 167
 None
 1.23A 4oltA-1j0aA:
0.0		 4oltA-1j0aA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 5 THR A  22
THR A  46
ASP A  43
TYR A 167
 None
 1.20A 4oltB-1j0aA:
0.0		 4oltB-1j0aA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 5 THR A  22
THR A  46
ASP A  43
TYR A 167
 None
 1.20A 4qwpA-1j0aA:
0.0		 4qwpA-1j0aA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 5 THR A  22
THR A  46
ASP A  43
TYR A 167
 None
 1.20A 4qwpB-1j0aA:
0.0		 4qwpB-1j0aA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 8 SER A 191
GLY A 193
ILE A  55
GLY A 163
 PLP  A 401 (-2.6A)
PLP  A 401 (-3.6A)
None
None
 0.81A 5alcL-1j0aA:
undetectable		 5alcL-1j0aA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 6 LEU A  94
ALA A  90
LEU A  96
THR A  87
 None
 0.94A 5bojA-1j0aA:
undetectable		 5bojA-1j0aA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A  30
LEU A  27
ARG A 268
LEU A 278
 None
 0.99A 5iy5A-1j0aA:
0.0
5iy5J-1j0aA:
0.0		 5iy5A-1j0aA:
20.99
5iy5J-1j0aA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 6 LEU A  94
ALA A  90
LEU A  96
THR A  87
 None
 0.91A 5l4iA-1j0aA:
undetectable		 5l4iA-1j0aA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 172
ASN A 206
GLU A 207
GLU A 243
LEU A 202
 None
 0.96A 5nwuA-1j0aA:
0.0		 5nwuA-1j0aA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 5 HIS A  83
VAL A  86
LEU A 100
THR A  75
 None
 1.35A 5ohhA-1j0aA:
undetectable		 5ohhA-1j0aA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		3 / 3 HIS A  80
SER A  81
ARG A 103
 None
SO4  A 701 (-2.3A)
None
 1.02A 5u63A-1j0aA:
4.0		 5u63A-1j0aA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A 291
TYR A 288
GLU A  33
 None
 0.81A 5zmqD-1j0aA:
0.0
5zmqE-1j0aA:
undetectable		 5zmqD-1j0aA:
23.18
5zmqE-1j0aA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 7 THR A 122
LEU A 100
ILE A  74
THR A  75
 None
 1.02A 5zsfA-1j0aA:
0.0
5zsfB-1j0aA:
0.0		 5zsfA-1j0aA:
13.85
5zsfB-1j0aA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_2
(-)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 4 GLN A 177
THR A  22
THR A 194
LEU A 304
 None
None
PLP  A 401 (-3.8A)
None
 1.44A 6f3mA-1j0aA:
2.2		 6f3mA-1j0aA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_C_ADNC502_2
(-)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		4 / 4 GLN A 177
THR A  22
THR A 194
LEU A 304
 None
None
PLP  A 401 (-3.8A)
None
 1.46A 6f3mC-1j0aA:
2.2		 6f3mC-1j0aA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 309
TYR A 317
ILE A 277
HIS A  80
TYR A 256
 PLP  A 401 (-3.9A)
None
None
None
None
 1.44A 6md4A-1j0aA:
undetectable		 6md4A-1j0aA:
15.86