SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1j0h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		7 / 12 HIS A 205
TYR A 207
ASP A 328
HIS A 423
ASP A 424
ASP A 468
ARG A 472
 None
 0.68A 1dedA-1j0hA:
39.3		 1dedA-1j0hA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		6 / 12 HIS A 205
TYR A 207
GLU A 357
ASP A 424
ASP A 468
ARG A 472
 None
 0.99A 1dedA-1j0hA:
39.3		 1dedA-1j0hA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		8 / 12 HIS A 205
TYR A 207
ARG A 326
ASP A 328
GLU A 357
HIS A 423
ASP A 424
ARG A 472
 None
 0.71A 1dedB-1j0hA:
37.2		 1dedB-1j0hA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 354
GLY A 356
HIS A 423
MET A 240
TYR A 207
 None
 1.15A 1fm6X-1j0hA:
undetectable		 1fm6X-1j0hA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 428
ALA A 388
LEU A 441
LEU A 384
LEU A 486
 None
 0.81A 1fm9A-1j0hA:
undetectable		 1fm9A-1j0hA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 428
ALA A 388
LEU A 441
LEU A 384
LEU A 486
 None
 0.80A 1k74A-1j0hA:
undetectable		 1k74A-1j0hA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		8 / 12 TYR A 207
HIS A 247
PHE A 289
ARG A 326
ASP A 328
GLU A 357
HIS A 423
ASP A 424
 None
 0.62A 1mxdA-1j0hA:
28.8		 1mxdA-1j0hA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		4 / 6 ARG A 326
ILE A 358
TRP A 359
GLU A 332
 None
 1.21A 1nsiA-1j0hA:
0.0
1nsiB-1j0hA:
0.0		 1nsiA-1j0hA:
22.09
1nsiB-1j0hA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 416
GLY A 451
GLY A 368
ARG A 367
PRO A 409
 None
 0.97A 1sqfA-1j0hA:
undetectable		 1sqfA-1j0hA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		4 / 5 PHE A 387
LEU A 420
PHE A 397
MET A 401
 None
 1.15A 1wrlC-1j0hA:
undetectable		 1wrlC-1j0hA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		4 / 7 PHE A 387
LEU A 420
PHE A 397
MET A 401
 None
 1.15A 1wrlE-1j0hA:
undetectable		 1wrlE-1j0hA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_B_EDTB1511_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		4 / 8 TYR A 250
TRP A 259
TYR A 286
THR A 288
 None
 1.24A 1zlqB-1j0hA:
0.3		 1zlqB-1j0hA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		5 / 12 TYR A 138
GLY A 458
GLY A 462
ILE A 140
PHE A 145
 None
 1.42A 2akeA-1j0hA:
undetectable		 2akeA-1j0hA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		6 / 12 ASP A 459
GLY A 458
VAL A 439
ILE A 436
VAL A 431
ILE A 428
 None
 1.44A 2avvB-1j0hA:
undetectable		 2avvB-1j0hA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		3 / 3 THR A 280
PRO A 282
PRO A 284
 None
 0.85A 2d55C-1j0hA:
undetectable		 2d55C-1j0hA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		5 / 11 TYR A 138
GLY A 458
GLY A 462
ILE A 140
PHE A 145
 None
 1.42A 2dr2A-1j0hA:
undetectable		 2dr2A-1j0hA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A 309
PRO A 197
GLU A 357
ARG A 326
 None
 1.06A 2jn3A-1j0hA:
undetectable		 2jn3A-1j0hA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		6 / 12 GLY A 465
ASP A 459
LEU A 420
GLY A 421
ASP A 424
LEU A 384
 None
 1.38A 2nxeA-1j0hA:
undetectable		 2nxeA-1j0hA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		6 / 12 GLY A 466
ASP A 459
LEU A 420
GLY A 421
ASP A 424
LEU A 384
 None
 1.37A 2nxeA-1j0hA:
undetectable		 2nxeA-1j0hA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 339
GLU A 336
GLN A 370
 None
 1.04A 2p16A-1j0hA:
0.0		 2p16A-1j0hA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		4 / 7 TYR A 377
ASP A 328
TYR A 207
HIS A 423
 None
 1.45A 2pncA-1j0hA:
undetectable		 2pncA-1j0hA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		6 / 12 ASP A 459
GLY A 458
VAL A 439
ILE A 436
VAL A 431
ILE A 428
 None
 1.43A 2q63A-1j0hA:
undetectable		 2q63A-1j0hA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		6 / 12 ASP A 459
GLY A 458
VAL A 439
ILE A 436
VAL A 431
ILE A 428
 None
 1.46A 2q64B-1j0hA:
undetectable		 2q64B-1j0hA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		4 / 8 ILE A 508
LEU A 520
PHE A 445
PHE A 379
 None
 0.87A 2vctA-1j0hA:
0.0		 2vctA-1j0hA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		4 / 8 ILE A 508
LEU A 520
PHE A 445
PHE A 379
 None
 0.85A 2vctB-1j0hA:
0.0		 2vctB-1j0hA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		4 / 8 ILE A 508
LEU A 520
PHE A 445
PHE A 379
 None
 0.81A 2vctC-1j0hA:
0.0		 2vctC-1j0hA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		5 / 12 ARG A 326
ASP A 328
GLU A 357
HIS A 423
ASP A 424
 None
 0.66A 3aicB-1j0hA:
5.8		 3aicB-1j0hA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_C_ACRC5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		6 / 12 ARG A 326
ASP A 328
GLU A 357
HIS A 423
ASP A 424
TYR A 207
 None
 0.70A 3aicC-1j0hA:
9.6		 3aicC-1j0hA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_D_ACRD5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		5 / 12 ARG A 326
ASP A 328
GLU A 357
HIS A 423
ASP A 424
 None
 0.75A 3aicD-1j0hA:
7.7		 3aicD-1j0hA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		5 / 12 ARG A 326
ASP A 328
GLU A 357
HIS A 423
ASP A 424
 None
 0.71A 3aicE-1j0hA:
8.1		 3aicE-1j0hA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		5 / 12 ARG A 326
ASP A 328
GLU A 357
HIS A 423
ASP A 424
 None
 0.69A 3aicF-1j0hA:
7.3		 3aicF-1j0hA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		5 / 12 ARG A 326
ASP A 328
GLU A 357
HIS A 423
ASP A 424
 None
 0.67A 3aicG-1j0hA:
9.6		 3aicG-1j0hA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		5 / 12 ASN A 418
THR A 450
VAL A 383
LEU A 442
TYR A 522
 None
 1.10A 3elzA-1j0hA:
0.0		 3elzA-1j0hA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		5 / 12 ASN A 418
THR A 450
VAL A 383
LEU A 442
TYR A 522
 None
 1.16A 3elzC-1j0hA:
0.0		 3elzC-1j0hA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		5 / 8 ALA A 243
ASP A 328
ASP A 242
GLY A 356
VAL A 352
 None
 1.29A 3em6A-1j0hA:
undetectable		 3em6A-1j0hA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 428
ALA A 388
LEU A 384
ILE A 455
LEU A 486
 None
 0.70A 3oapA-1j0hA:
undetectable		 3oapA-1j0hA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		4 / 5 GLY A 506
ASP A 526
ARG A 505
GLN A 499
 None
 1.31A 3qx3B-1j0hA:
0.5		 3qx3B-1j0hA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		3 / 3 LEU A  39
HIS A  41
MET A  57
 None
 0.83A 3thrD-1j0hA:
undetectable		 3thrD-1j0hA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		5 / 9 LEU A 444
ILE A 544
ILE A 546
PHE A 580
VAL A 581
 None
 1.50A 3tmzA-1j0hA:
0.0		 3tmzA-1j0hA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		4 / 8 TYR A  16
HIS A   8
LEU A  39
MET A  57
 None
 1.32A 3uzzB-1j0hA:
5.1		 3uzzB-1j0hA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A 490
ILE A 190
TYR A 353
SER A 452
LEU A 447
 None
 1.32A 4a84A-1j0hA:
undetectable		 4a84A-1j0hA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		4 / 7 PHE A 379
GLY A 451
ILE A 508
LEU A 405
 None
 0.85A 4ejjD-1j0hA:
undetectable		 4ejjD-1j0hA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		4 / 7 ARG A 326
ILE A 358
TRP A 359
GLU A 332
 None
 1.24A 4nosC-1j0hA:
0.0
4nosD-1j0hA:
0.0		 4nosC-1j0hA:
22.24
4nosD-1j0hA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 428
ALA A 388
LEU A 384
ILE A 455
LEU A 486
 None
 0.88A 4nqaH-1j0hA:
undetectable		 4nqaH-1j0hA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		4 / 7 ARG A 504
THR A 450
GLY A 451
VAL A 132
 None
 0.99A 4qwpB-1j0hA:
undetectable		 4qwpB-1j0hA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		4 / 8 VAL A 439
LEU A 442
PHE A 379
GLY A 382
 None
 0.86A 4r3aA-1j0hA:
undetectable		 4r3aA-1j0hA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		4 / 5 ILE A 198
HIS A 247
TYR A 308
VAL A 312
 None
 0.89A 4s0vA-1j0hA:
undetectable		 4s0vA-1j0hA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		3 / 3 LEU A 298
VAL A 329
ASP A 328
 None
 0.50A 4y8wC-1j0hA:
0.1		 4y8wC-1j0hA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8T_D_SAMD605_0
(GUANINE-N7
METHYLTRANSFERASE)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		5 / 10 GLY A 148
ASN A 149
PRO A 150
ALA A 146
PHE A 145
 None
None
CA  A 601 ( 4.6A)
None
None
 1.48A 5c8tD-1j0hA:
0.5		 5c8tD-1j0hA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_1
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		5 / 12 ARG A 326
ASP A 328
GLU A 357
HIS A 423
ASP A 424
 None
 0.48A 5csyB-1j0hA:
19.8		 5csyB-1j0hA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		4 / 5 ILE A 178
ILE A 237
HIS A 233
VAL A 239
 None
 0.75A 5jmnA-1j0hA:
undetectable		 5jmnA-1j0hA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		3 / 3 THR A 425
SER A 422
ASP A 328
 None
 0.85A 5kvaA-1j0hA:
1.1		 5kvaA-1j0hA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		3 / 3 THR A 425
SER A 422
ASP A 328
 None
 0.85A 5kvaB-1j0hA:
1.1		 5kvaB-1j0hA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		5 / 12 PHE A 145
TRP A 477
ARG A 144
GLU A 143
GLY A 172
 None
None
None
None
CA  A 601 (-3.9A)
 1.14A 5o4yD-1j0hA:
undetectable
5o4yE-1j0hA:
4.2		 5o4yD-1j0hA:
2.85
5o4yE-1j0hA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 428
ALA A 388
LEU A 441
LEU A 384
LEU A 486
 None
 0.87A 5z12B-1j0hA:
undetectable		 5z12B-1j0hA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 428
ALA A 388
LEU A 384
ILE A 455
LEU A 486
 None
 0.55A 6a5yD-1j0hA:
undetectable		 6a5yD-1j0hA:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 428
ALA A 388
LEU A 384
ILE A 455
LEU A 486
 None
 0.78A 6a5zL-1j0hA:
undetectable		 6a5zL-1j0hA:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 428
ALA A 388
LEU A 441
ILE A 455
LEU A 486
 None
 0.99A 6a60D-1j0hA:
undetectable		 6a60D-1j0hA:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		6 / 12 TYR A 207
HIS A 247
MET A 295
ASP A 328
HIS A 423
ASP A 424
 None
 1.16A 6ag0A-1j0hA:
24.5		 6ag0A-1j0hA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		4 / 6 TRP A 160
LEU A 175
TYR A 457
GLN A 482
 None
 1.21A 6djzC-1j0hA:
3.0		 6djzC-1j0hA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1j0h NEOPULLULANASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 177
TYR A 456
PHE A 443
ILE A 428
GLY A 462
 None
 1.20A 6e8qA-1j0hA:
undetectable		 6e8qA-1j0hA:
8.78