SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1j1u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 8 ALA A 290
GLU A 294
LEU A 253
LEU A 282
 None
 0.98A 1ereE-1j1uA:
undetectable		 1ereE-1j1uA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 8 ALA A 290
GLU A 294
LEU A 253
LEU A 282
 None
 0.96A 1ereF-1j1uA:
undetectable		 1ereF-1j1uA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 11 GLY A  34
HIS A  42
HIS A  45
GLY A 170
GLN A 173
 TYR  A 401 (-3.4A)
None
None
None
TYR  A 401 (-3.0A)
 0.61A 1jzsA-1j1uA:
0.3		 1jzsA-1j1uA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  55
LEU A  20
SER A  16
ARG A 181
THR A  11
 None
 1.08A 1qzfA-1j1uA:
undetectable		 1qzfA-1j1uA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  55
LEU A  20
SER A  16
ARG A 181
THR A  11
 None
 1.08A 1qzfB-1j1uA:
undetectable		 1qzfB-1j1uA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  55
LEU A  20
SER A  16
ARG A 181
THR A  11
 None
 1.08A 1qzfC-1j1uA:
undetectable		 1qzfC-1j1uA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  55
LEU A  20
SER A  16
ARG A 181
THR A  11
 None
 1.09A 1qzfD-1j1uA:
undetectable		 1qzfD-1j1uA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  55
LEU A  20
SER A  16
ARG A 181
THR A  11
 None
 1.09A 1qzfE-1j1uA:
undetectable		 1qzfE-1j1uA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ALA A 292
LEU A 295
ILE A 244
CYH A 231
 None
None
None
U  B 536 ( 4.3A)
 1.08A 1sbrA-1j1uA:
0.0
1sbrB-1j1uA:
0.0		 1sbrA-1j1uA:
21.77
1sbrB-1j1uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 8 LEU A  69
GLY A 105
LEU A  79
PRO A  37
 None
 0.77A 1ya4A-1j1uA:
undetectable		 1ya4A-1j1uA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 LEU A  69
GLY A 105
LEU A  79
PRO A  37
 None
 0.79A 1ya4B-1j1uA:
1.7		 1ya4B-1j1uA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  55
LEU A  20
SER A  16
ARG A 181
THR A  11
 None
 1.04A 2oipB-1j1uA:
undetectable		 2oipB-1j1uA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  55
LEU A  20
SER A  16
ARG A 181
THR A  11
 None
 1.05A 2oipC-1j1uA:
undetectable		 2oipC-1j1uA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 TYR A 161
ILE A  63
VAL A 103
PHE A 108
ASP A 111
 None
 1.49A 2qeoA-1j1uA:
0.0		 2qeoA-1j1uA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 HIS A  42
GLY A  44
HIS A  45
GLY A 170
LEU A 196
 None
 0.68A 2x1lB-1j1uA:
10.8		 2x1lB-1j1uA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 5 ILE A  85
SER A  38
PRO A  37
PHE A  35
 None
 1.14A 3bjwC-1j1uA:
0.0		 3bjwC-1j1uA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ALA A 290
GLU A 294
LEU A 273
LEU A 253
LEU A 282
 None
 1.46A 3erdB-1j1uA:
undetectable		 3erdB-1j1uA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.84A 3fhjA-1j1uA:
19.1		 3fhjA-1j1uA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.83A 3fhjB-1j1uA:
18.2		 3fhjB-1j1uA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.83A 3fhjC-1j1uA:
17.5		 3fhjC-1j1uA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.83A 3fhjD-1j1uA:
19.6		 3fhjD-1j1uA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.83A 3fhjE-1j1uA:
18.8		 3fhjE-1j1uA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.83A 3fhjF-1j1uA:
19.9		 3fhjF-1j1uA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 8 HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.42A 3fi0B-1j1uA:
18.8		 3fi0B-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.83A 3fi0C-1j1uA:
19.1		 3fi0C-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.84A 3fi0D-1j1uA:
18.3		 3fi0D-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 GLY A  34
HIS A  70
ASP A 158
ILE A 159
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
 0.60A 3fi0E-1j1uA:
17.1		 3fi0E-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.42A 3fi0E-1j1uA:
17.1		 3fi0E-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.83A 3fi0F-1j1uA:
18.7		 3fi0F-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 8 GLY A  34
HIS A  70
ASP A 158
ILE A 159
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
 0.61A 3fi0G-1j1uA:
19.3		 3fi0G-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 8 HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.41A 3fi0G-1j1uA:
19.3		 3fi0G-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.85A 3fi0H-1j1uA:
18.7		 3fi0H-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 8 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.87A 3fi0I-1j1uA:
18.8		 3fi0I-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.84A 3fi0J-1j1uA:
18.9		 3fi0J-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.84A 3fi0K-1j1uA:
18.1		 3fi0K-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.82A 3fi0L-1j1uA:
18.2		 3fi0L-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.87A 3fi0M-1j1uA:
2.5		 3fi0M-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.90A 3fi0N-1j1uA:
19.0		 3fi0N-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 GLY A  34
HIS A  70
ASP A 158
ILE A 159
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
 0.60A 3fi0P-1j1uA:
18.3		 3fi0P-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.45A 3fi0P-1j1uA:
18.3		 3fi0P-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.86A 3fi0R-1j1uA:
18.3		 3fi0R-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  55
LEU A  20
SER A  16
ARG A 181
THR A  11
 None
 1.02A 3hj3A-1j1uA:
undetectable		 3hj3A-1j1uA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  55
LEU A  20
SER A  16
ARG A 181
THR A  11
 None
 1.05A 3hj3C-1j1uA:
undetectable		 3hj3C-1j1uA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O01_B_DXCB1_0
(CELL INVASION
PROTEIN SIPD)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ILE A 213
LYS A 225
ASN A 289
ALA A 292
LEU A 299
 None
 1.26A 3o01A-1j1uA:
0.0
3o01B-1j1uA:
0.1		 3o01A-1j1uA:
21.53
3o01B-1j1uA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A 213
LYS A 225
ASN A 289
ALA A 292
LEU A 299
 None
 1.24A 3o02A-1j1uA:
0.0
3o02B-1j1uA:
0.0		 3o02A-1j1uA:
21.53
3o02B-1j1uA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RLB_B_VIBB187_1
(THIT)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  49
TYR A 102
GLY A  86
TYR A  88
VAL A  92
 None
 1.42A 3rlbB-1j1uA:
0.0		 3rlbB-1j1uA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  63
LEU A  55
ILE A  49
LEU A  98
ILE A  64
 None
 1.00A 4i13A-1j1uA:
undetectable		 4i13A-1j1uA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  55
LEU A  20
SER A  16
ARG A 181
THR A  11
 None
 1.04A 4ky8A-1j1uA:
undetectable		 4ky8A-1j1uA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  55
LEU A  20
SER A  16
ARG A 181
THR A  11
 None
 1.03A 4ky8B-1j1uA:
undetectable		 4ky8B-1j1uA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  55
LEU A  20
SER A  16
ARG A 181
THR A  11
 None
 1.07A 4ky8C-1j1uA:
undetectable		 4ky8C-1j1uA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  55
LEU A  20
SER A  16
ARG A 181
THR A  11
 None
 1.04A 4ky8D-1j1uA:
undetectable		 4ky8D-1j1uA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  55
LEU A  20
SER A  16
ARG A 181
THR A  11
 None
 1.04A 4ky8E-1j1uA:
undetectable		 4ky8E-1j1uA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 8 LEU A 249
TYR A 251
LEU A 282
LEU A 287
 None
 1.03A 4l1xA-1j1uA:
0.4		 4l1xA-1j1uA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  55
LEU A  20
SER A  16
ARG A 181
THR A  11
 None
 1.02A 4q0dA-1j1uA:
undetectable		 4q0dA-1j1uA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  55
LEU A  20
SER A  16
ARG A 181
THR A  11
 None
 1.02A 4q0dB-1j1uA:
undetectable		 4q0dB-1j1uA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  55
LEU A  20
SER A  16
ARG A 181
THR A  11
 None
 1.02A 4q0dC-1j1uA:
undetectable		 4q0dC-1j1uA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  55
LEU A  20
SER A  16
ARG A 181
THR A  11
 None
 1.02A 4q0dD-1j1uA:
undetectable		 4q0dD-1j1uA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  55
LEU A  20
SER A  16
ARG A 181
THR A  11
 None
 1.01A 4q0dE-1j1uA:
undetectable		 4q0dE-1j1uA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  24
LEU A  55
MET A  52
VAL A 189
ILE A 191
 None
 1.03A 4x1yD-1j1uA:
undetectable		 4x1yD-1j1uA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A  24
LEU A  55
MET A  52
VAL A 189
ILE A 191
 None
 1.09A 4x20D-1j1uA:
undetectable		 4x20D-1j1uA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  33
GLY A 170
ASN A 193
GLU A  94
ILE A  41
 None
 1.18A 5igyA-1j1uA:
0.0		 5igyA-1j1uA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ILE A 241
ILE A 244
ILE A 222
ALA A 292
LEU A 295
 None
 0.96A 5mvmA-1j1uA:
0.0
5mvmE-1j1uA:
0.0		 5mvmA-1j1uA:
16.53
5mvmE-1j1uA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ILE A 222
ALA A 292
LEU A 295
ILE A 244
 None
 0.87A 5mvmB-1j1uA:
0.0
5mvmC-1j1uA:
undetectable		 5mvmB-1j1uA:
16.53
5mvmC-1j1uA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A 222
ALA A 292
LEU A 295
ILE A 241
ILE A 244
 None
 0.94A 5mvmD-1j1uA:
0.0
5mvmE-1j1uA:
0.0		 5mvmD-1j1uA:
16.53
5mvmE-1j1uA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODH_G_ACTG710_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 4 ARG A 305
ILE A 302
TYR A  46
ILE A 298
 None
 1.42A 5odhG-1j1uA:
2.4		 5odhG-1j1uA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_A_TRPA402_0
(TRYPTOPHAN--TRNA
LIGASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.73A 5v0iA-1j1uA:
19.0		 5v0iA-1j1uA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_B_TRPB402_0
(TRYPTOPHAN--TRNA
LIGASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.72A 5v0iB-1j1uA:
19.5		 5v0iB-1j1uA:
24.86