SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1j2b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 12 PHE A 417
GLN A 419
ILE A 403
LEU A 368
TYR A 353
 None
G  C 909 ( 4.1A)
None
None
None
 1.23A 1dlsA-1j2bA:
undetectable		 1dlsA-1j2bA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		4 / 6 TYR A  65
GLY A  97
GLY A 105
TYR A 104
 U  D 917 ( 4.4A)
None
None
U  D 917 ( 3.1A)
 0.99A 1eswA-1j2bA:
6.6		 1eswA-1j2bA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 12 ASP A 535
GLY A 537
ASP A 542
GLY A 449
PRO A 504
 None
 0.84A 1hsgB-1j2bA:
undetectable		 1hsgB-1j2bA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 12 ASP A 535
GLY A 537
ASP A 542
GLY A 449
PRO A 504
 None
 0.87A 1k6cB-1j2bA:
undetectable		 1k6cB-1j2bA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI2_B_GA2B2_1
(THYMIDINE KINASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 12 GLU A 397
ILE A 437
ARG A 409
TYR A 439
GLU A 434
 None
 1.20A 1ki2B-1j2bA:
0.0		 1ki2B-1j2bA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A 356
PHE A 355
GLY A  17
VAL A 319
LEU A 349
 None
 1.15A 1mx1A-1j2bA:
undetectable		 1mx1A-1j2bA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 126
VAL A 123
ASP A 124
ALA A 166
HIS A 227
 None
 1.23A 1nbhC-1j2bA:
0.5		 1nbhC-1j2bA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		4 / 4 ILE A 131
ARG A 152
ASP A  95
ASN A  41
 None
None
G  D 915 ( 3.3A)
U  D 916 ( 4.7A)
 1.47A 1nbiC-1j2bA:
0.4		 1nbiC-1j2bA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		4 / 4 ILE A 131
ARG A 152
ASP A  95
ASN A  41
 None
None
G  D 915 ( 3.3A)
U  D 916 ( 4.7A)
 1.45A 1nbiD-1j2bA:
0.3		 1nbiD-1j2bA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		4 / 8 GLY A  17
GLY A  19
GLY A 244
MET A 243
 None
 0.63A 1qzzA-1j2bA:
2.6		 1qzzA-1j2bA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		4 / 8 GLU A 360
TRP A 378
GLU A 327
ASP A  16
 None
 1.30A 1s3zA-1j2bA:
undetectable
1s3zB-1j2bA:
undetectable		 1s3zA-1j2bA:
13.60
1s3zB-1j2bA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		3 / 3 ARG A 207
ARG A 348
ILE A 212
 G  D 938 ( 4.4A)
None
None
 0.80A 1uobA-1j2bA:
0.0		 1uobA-1j2bA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		4 / 6 TYR A 256
SER A 250
ALA A 251
SER A 252
 U  D 913 ( 4.0A)
A  D 914 ( 3.5A)
G  D 915 ( 2.9A)
A  D 914 ( 4.0A)
 1.00A 1yvpB-1j2bA:
undetectable		 1yvpB-1j2bA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		3 / 3 ASP A 246
PHE A  10
ARG A  20
 None
 0.78A 2a3aA-1j2bA:
10.4		 2a3aA-1j2bA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		4 / 6 TYR A 541
GLY A 244
PHE A 359
ARG A  20
 None
 1.35A 2a3cB-1j2bA:
10.1		 2a3cB-1j2bA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 12 ASP A 535
GLY A 537
ASP A 542
GLY A 449
PRO A 504
 None
 0.84A 2avoB-1j2bA:
undetectable		 2avoB-1j2bA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 12 ASP A 535
GLY A 537
ASP A 542
GLY A 449
PRO A 504
 None
 0.83A 2avvB-1j2bA:
undetectable		 2avvB-1j2bA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		4 / 8 SER A  96
PHE A 128
LEU A 184
LEU A 146
 G  D 915 ( 4.2A)
None
None
None
 0.94A 2bfpB-1j2bA:
undetectable		 2bfpB-1j2bA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		4 / 8 SER A  96
PHE A 128
LEU A 184
LEU A 146
 G  D 915 ( 4.2A)
None
None
None
 0.95A 2bfpC-1j2bA:
undetectable		 2bfpC-1j2bA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 12 ASP A 535
GLY A 537
ASP A 542
GLY A 449
PRO A 504
 None
 0.78A 2f81B-1j2bA:
undetectable		 2f81B-1j2bA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_1
(HYPOTHETICAL PROTEIN
LMO1582)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		4 / 4 THR A 414
THR A 363
ASP A 542
ASP A 535
 None
 1.34A 2f8lA-1j2bA:
undetectable		 2f8lA-1j2bA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 11 ASP A 535
GLY A 537
ASP A 542
GLY A 449
PRO A 504
 None
 0.87A 2fxeB-1j2bA:
undetectable		 2fxeB-1j2bA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 12 ASP A 535
GLY A 537
ASP A 542
GLY A 449
PRO A 504
 None
 0.66A 2hs1A-1j2bA:
undetectable		 2hs1A-1j2bA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_1
(PROTEASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 12 ASP A 535
GLY A 537
ASP A 542
GLY A 449
PRO A 504
 None
 0.76A 2hs2A-1j2bA:
undetectable		 2hs2A-1j2bA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 12 ASP A 535
GLY A 537
ASP A 542
GLY A 449
PRO A 504
 None
 0.70A 2ienB-1j2bA:
undetectable		 2ienB-1j2bA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 12 ASP A 535
GLY A 537
ASP A 542
GLY A 449
PRO A 504
 None
 0.90A 2ieoA-1j2bA:
undetectable		 2ieoA-1j2bA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 11 ASP A 535
GLY A 537
ASP A 542
GLY A 449
PRO A 504
 None
 0.89A 2r5qB-1j2bA:
undetectable		 2r5qB-1j2bA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_2
(PROTEASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 10 ASP A 535
GLY A 537
ASP A 542
GLY A 449
PRO A 504
 None
 0.89A 2r5qD-1j2bA:
undetectable		 2r5qD-1j2bA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		3 / 3 SER A 185
HIS A 227
ASP A  95
 None
None
G  D 915 ( 3.3A)
 0.74A 2wa2B-1j2bA:
undetectable		 2wa2B-1j2bA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A 356
ALA A 242
GLY A 244
PHE A 355
 None
 0.94A 2wq5A-1j2bA:
0.0		 2wq5A-1j2bA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_2
(HIV-1 PROTEASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 12 ASP A 535
GLY A 537
ASP A 542
GLY A 449
PRO A 504
 None
 0.72A 3d20B-1j2bA:
undetectable		 3d20B-1j2bA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 11 ASP A 535
GLY A 537
ASP A 542
GLY A 449
PRO A 504
 None
 0.72A 3ektC-1j2bA:
undetectable		 3ektC-1j2bA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 10 ASP A 535
GLY A 537
ASP A 542
GLY A 449
PRO A 504
 None
 0.86A 3ekyA-1j2bA:
undetectable		 3ekyA-1j2bA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 10 ASP A 535
GLY A 537
ASP A 542
GLY A 449
PRO A 504
 None
 0.83A 3el9B-1j2bA:
undetectable		 3el9B-1j2bA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 11 ASP A 535
GLY A 537
ASP A 542
GLY A 449
PRO A 504
 None
 0.90A 3em4U-1j2bA:
undetectable		 3em4U-1j2bA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		3 / 3 LEU A 545
LEU A 553
ARG A 501
 None
 0.74A 3hcnB-1j2bA:
undetectable		 3hcnB-1j2bA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 8 LEU A 491
VAL A 440
VAL A 472
ARG A 478
LEU A 479
 None
None
None
G  C 969 ( 3.1A)
None
 1.14A 3kp6A-1j2bA:
undetectable
3kp6B-1j2bA:
undetectable		 3kp6A-1j2bA:
14.75
3kp6B-1j2bA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 12 ASP A 535
GLY A 537
ASP A 542
GLY A 449
PRO A 504
 None
 0.80A 3lzuB-1j2bA:
undetectable		 3lzuB-1j2bA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEE_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 12 PRO A 379
LYS A 365
PHE A 369
LEU A 368
TYR A 415
 None
 1.23A 3meeA-1j2bA:
0.0		 3meeA-1j2bA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 12 ASP A 535
GLY A 537
ASP A 542
GLY A 449
PRO A 504
 None
 0.76A 3s54B-1j2bA:
undetectable		 3s54B-1j2bA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		4 / 5 SER A 185
ARG A 224
PRO A 225
VAL A 226
 None
 1.29A 3sufC-1j2bA:
0.0		 3sufC-1j2bA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 10 ASP A 535
GLY A 537
ASP A 542
GLY A 449
PRO A 504
 None
 0.80A 3ttpA-1j2bA:
undetectable		 3ttpA-1j2bA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_2
(HIV-1 PROTEASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 10 ASP A 535
GLY A 537
ASP A 542
GLY A 449
PRO A 504
 None
 0.78A 3ttpB-1j2bA:
undetectable		 3ttpB-1j2bA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 11 ASP A 535
GLY A 537
ASP A 542
GLY A 449
PRO A 504
 None
 0.90A 3ufnA-1j2bA:
undetectable		 3ufnA-1j2bA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 12 TYR A 541
ILE A  21
GLU A 360
GLY A  19
GLY A 244
 None
 1.04A 4hfpB-1j2bA:
undetectable		 4hfpB-1j2bA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A  26
GLY A  28
LYS A  30
 None
 0.75A 4k50A-1j2bA:
0.0		 4k50A-1j2bA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A  26
GLY A  28
LYS A  30
 None
 0.75A 4k50E-1j2bA:
0.0		 4k50E-1j2bA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A  26
GLY A  28
LYS A  30
 None
 0.76A 4k50I-1j2bA:
0.0		 4k50I-1j2bA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 232
ALA A 231
LEU A 228
MET A 243
LEU A 239
 A  D 914 ( 3.4A)
A  D 914 ( 4.6A)
None
None
None
 0.90A 4o3fA-1j2bA:
undetectable		 4o3fA-1j2bA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 7 LEU A 150
ALA A 153
LEU A 184
ALA A 166
LEU A 146
 None
 1.09A 4z90F-1j2bA:
0.0
4z90G-1j2bA:
undetectable
4z90H-1j2bA:
0.0
4z90J-1j2bA:
0.0		 4z90F-1j2bA:
21.12
4z90G-1j2bA:
21.12
4z90H-1j2bA:
21.12
4z90J-1j2bA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 10 MET A 187
LEU A 184
LEU A 150
GLY A 195
GLN A 169
 None
None
None
G  D 915 ( 4.2A)
G  D 915 ( 3.9A)
 1.38A 4zp0A-1j2bA:
undetectable		 4zp0A-1j2bA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 12 PRO A 379
LYS A 365
PHE A 369
LEU A 368
TYR A 415
 None
 1.24A 5cymA-1j2bA:
0.0		 5cymA-1j2bA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 12 PRO A 379
LYS A 365
PHE A 369
LEU A 368
TYR A 415
 None
 1.24A 5cyqA-1j2bA:
0.0		 5cyqA-1j2bA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 12 ASP A 535
GLY A 537
ASP A 542
GLY A 449
PRO A 504
 None
 0.71A 5e5kA-1j2bA:
undetectable		 5e5kA-1j2bA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		4 / 4 LEU A 201
TYR A 253
PRO A 234
ILE A 235
 A  D 914 ( 3.8A)
None
None
None
 1.41A 5esgA-1j2bA:
undetectable		 5esgA-1j2bA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		4 / 8 LEU A 349
LEU A 328
TRP A 329
ALA A 240
 None
 0.81A 5f1aA-1j2bA:
0.0		 5f1aA-1j2bA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		3 / 3 ALA A 305
ASN A 308
LEU A 309
 None
 0.50A 5i1oA-1j2bA:
undetectable		 5i1oA-1j2bA:
4.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		3 / 3 ALA A 305
ASN A 308
LEU A 309
 None
 0.49A 5i1pD-1j2bA:
undetectable		 5i1pD-1j2bA:
4.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 8 VAL A 319
ILE A 316
ALA A  35
VAL A 245
VAL A 241
 None
 1.33A 5l94A-1j2bA:
undetectable		 5l94A-1j2bA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 12 ASP A 535
GLY A 537
ASP A 542
GLY A 449
PRO A 504
 None
 0.72A 5t2zB-1j2bA:
undetectable		 5t2zB-1j2bA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 12 ASP A 535
GLY A 537
ASP A 542
GLY A 449
PRO A 504
 None
 0.71A 5t8hA-1j2bA:
undetectable		 5t8hA-1j2bA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		4 / 8 LEU A 479
ILE A 443
ALA A 444
LEU A 489
 None
 0.69A 5te8B-1j2bA:
0.0		 5te8B-1j2bA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		6 / 11 ASP A 130
ILE A 131
ILE A 168
GLY A 195
GLY A 196
LEU A 150
 G  D 915 ( 3.0A)
None
None
G  D 915 ( 4.2A)
G  D 915 ( 4.2A)
None
 1.23A 5twjD-1j2bA:
undetectable		 5twjD-1j2bA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 9 ASP A 130
GLN A 169
GLY A 195
GLY A 196
VAL A 198
 G  D 915 ( 3.0A)
G  D 915 ( 3.9A)
G  D 915 ( 4.2A)
G  D 915 ( 4.2A)
None
 0.98A 5v3cA-1j2bA:
38.8		 5v3cA-1j2bA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		4 / 6 ILE A 443
LEU A 411
PHE A 417
PHE A 456
 None
 1.01A 5vkqA-1j2bA:
0.0
5vkqB-1j2bA:
0.0		 5vkqA-1j2bA:
15.89
5vkqB-1j2bA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		4 / 6 ILE A 443
LEU A 411
PHE A 417
PHE A 456
 None
 1.02A 5vkqB-1j2bA:
0.0
5vkqC-1j2bA:
0.1		 5vkqB-1j2bA:
15.89
5vkqC-1j2bA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		4 / 6 ILE A 443
LEU A 411
PHE A 417
PHE A 456
 None
 1.01A 5vkqC-1j2bA:
0.1
5vkqD-1j2bA:
0.1		 5vkqC-1j2bA:
15.89
5vkqD-1j2bA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		4 / 6 PHE A 456
ILE A 443
LEU A 411
PHE A 417
 None
 1.04A 5vkqA-1j2bA:
0.0
5vkqD-1j2bA:
0.1		 5vkqA-1j2bA:
15.89
5vkqD-1j2bA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_0
(PROTEASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 12 ASP A 535
GLY A 537
ASP A 542
GLY A 449
PRO A 504
 None
 0.69A 6dgxA-1j2bA:
undetectable		 6dgxA-1j2bA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 12 ASP A 535
GLY A 537
ASP A 542
GLY A 449
PRO A 504
 None
 0.69A 6dh3A-1j2bA:
undetectable		 6dh3A-1j2bA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		5 / 12 PRO A 379
LYS A 365
PHE A 369
LEU A 368
TYR A 415
 None
 1.28A 6eliA-1j2bA:
2.1		 6eliA-1j2bA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A  26
GLU A  25
ILE A  91
 None
 0.56A 6f7lB-1j2bA:
undetectable		 6f7lB-1j2bA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE
(Pyrococcus
horikoshii) 		4 / 6 ALA A 480
GLY A 487
THR A 414
PHE A 395
 None
 0.85A 6f8cA-1j2bA:
undetectable		 6f8cA-1j2bA:
8.42