SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1j31'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 1j31 HYPOTHETICAL PROTEIN
PH0642
(Pyrococcus
horikoshii) 		5 / 8 ILE A 193
ILE A 235
GLU A 234
VAL A 233
ILE A 212
 None
 1.13A 1linA-1j31A:
undetectable		 1linA-1j31A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1j31 HYPOTHETICAL PROTEIN
PH0642
(Pyrococcus
horikoshii) 		4 / 6 ILE A  13
GLU A 201
PHE A 123
ARG A 119
 None
 1.16A 1oniA-1j31A:
undetectable
1oniC-1j31A:
undetectable		 1oniA-1j31A:
17.36
1oniC-1j31A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1j31 HYPOTHETICAL PROTEIN
PH0642
(Pyrococcus
horikoshii) 		5 / 8 ALA A 223
ILE A 230
GLY A   5
ILE A 193
PRO A  41
 None
 1.44A 1sh9A-1j31A:
undetectable		 1sh9A-1j31A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1j31 HYPOTHETICAL PROTEIN
PH0642
(Pyrococcus
horikoshii) 		5 / 8 ILE A 193
ILE A 212
GLY A 231
ILE A 230
PRO A  41
 None
 1.31A 1sh9A-1j31A:
undetectable		 1sh9A-1j31A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 1j31 HYPOTHETICAL PROTEIN
PH0642
(Pyrococcus
horikoshii) 		4 / 6 LEU A  26
MET A   9
LEU A  40
GLU A  24
 None
 1.22A 2kuhA-1j31A:
undetectable		 2kuhA-1j31A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 1j31 HYPOTHETICAL PROTEIN
PH0642
(Pyrococcus
horikoshii) 		4 / 6 ASN A 171
ARG A 197
ASN A  49
GLU A 201
 None
 1.37A 3galA-1j31A:
undetectable		 3galA-1j31A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 1j31 HYPOTHETICAL PROTEIN
PH0642
(Pyrococcus
horikoshii) 		4 / 6 ASN A 171
ARG A 197
ASN A  49
GLU A 201
 None
 1.38A 3galB-1j31A:
undetectable		 3galB-1j31A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)		 1j31 HYPOTHETICAL PROTEIN
PH0642
(Pyrococcus
horikoshii) 		4 / 5 VAL A   2
ILE A 136
TYR A 111
MET A 144
 None
 1.50A 3gvuA-1j31A:
undetectable		 3gvuA-1j31A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 1j31 HYPOTHETICAL PROTEIN
PH0642
(Pyrococcus
horikoshii) 		4 / 7 GLU A 120
TYR A 111
GLU A  42
TYR A  48
 None
 1.36A 3ku9B-1j31A:
undetectable		 3ku9B-1j31A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1j31 HYPOTHETICAL PROTEIN
PH0642
(Pyrococcus
horikoshii) 		5 / 12 ILE A 166
VAL A 143
ILE A  27
LEU A  40
PRO A  41
 None
 0.86A 3mb5A-1j31A:
undetectable		 3mb5A-1j31A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1j31 HYPOTHETICAL PROTEIN
PH0642
(Pyrococcus
horikoshii) 		5 / 12 ILE A 166
VAL A 143
ILE A 230
ILE A  27
LEU A  40
 None
 1.04A 3mb5A-1j31A:
undetectable		 3mb5A-1j31A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1j31 HYPOTHETICAL PROTEIN
PH0642
(Pyrococcus
horikoshii) 		4 / 8 ASP A 135
ILE A 136
GLY A 137
VAL A   4
 None
 0.68A 4acbB-1j31A:
undetectable
4acbC-1j31A:
undetectable		 4acbB-1j31A:
18.43
4acbC-1j31A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1j31 HYPOTHETICAL PROTEIN
PH0642
(Pyrococcus
horikoshii) 		6 / 12 ILE A   7
VAL A  38
LEU A  37
GLY A 103
ALA A  76
LEU A  75
 None
 1.34A 4o1zA-1j31A:
undetectable		 4o1zA-1j31A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1j31 HYPOTHETICAL PROTEIN
PH0642
(Pyrococcus
horikoshii) 		4 / 6 ILE A 165
GLY A 142
ILE A 136
LEU A 237
 None
 0.76A 4o8fB-1j31A:
undetectable		 4o8fB-1j31A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1j31 HYPOTHETICAL PROTEIN
PH0642
(Pyrococcus
horikoshii) 		5 / 8 THR A  46
GLU A  51
LEU A  95
VAL A 122
GLY A  47
 None
 1.50A 4r3aA-1j31A:
undetectable		 4r3aA-1j31A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1j31 HYPOTHETICAL PROTEIN
PH0642
(Pyrococcus
horikoshii) 		5 / 12 ASP A 148
SER A 154
ALA A 163
ALA A 159
TYR A 111
 None
 1.32A 4u15B-1j31A:
undetectable		 4u15B-1j31A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1j31 HYPOTHETICAL PROTEIN
PH0642
(Pyrococcus
horikoshii) 		4 / 6 ASP A  45
ALA A  85
THR A  68
THR A  69
 None
 1.50A 4w5tA-1j31A:
undetectable		 4w5tA-1j31A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 1j31 HYPOTHETICAL PROTEIN
PH0642
(Pyrococcus
horikoshii) 		3 / 3 LYS A 113
ARG A  53
VAL A 122
 None
 0.93A 4x3uA-1j31A:
0.0
4x3uB-1j31A:
0.0		 4x3uA-1j31A:
13.89
4x3uB-1j31A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 1j31 HYPOTHETICAL PROTEIN
PH0642
(Pyrococcus
horikoshii) 		5 / 10 ASP A 148
ALA A  85
TYR A 111
SER A  98
GLY A  86
 None
 1.21A 4xp1A-1j31A:
0.0		 4xp1A-1j31A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1j31 HYPOTHETICAL PROTEIN
PH0642
(Pyrococcus
horikoshii) 		4 / 6 ASP A  45
ALA A  85
THR A  68
THR A  69
 None
 1.48A 4z4fA-1j31A:
2.4		 4z4fA-1j31A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CAD_A_ACTA402_0
(SM80.1 VICILIN)		 1j31 HYPOTHETICAL PROTEIN
PH0642
(Pyrococcus
horikoshii) 		4 / 6 PHE A 123
TYR A  48
ASN A  49
ARG A 119
 None
 1.26A 5cadA-1j31A:
0.0		 5cadA-1j31A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 1j31 HYPOTHETICAL PROTEIN
PH0642
(Pyrococcus
horikoshii) 		5 / 12 ASP A 148
SER A 154
ALA A 163
ALA A 159
TYR A 111
 None
 1.37A 5cxvA-1j31A:
undetectable		 5cxvA-1j31A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 1j31 HYPOTHETICAL PROTEIN
PH0642
(Pyrococcus
horikoshii) 		5 / 12 VAL A 141
ASP A 148
ALA A 167
THR A  87
ARG A 112
 None
 1.42A 5hnzB-1j31A:
undetectable		 5hnzB-1j31A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA302_0
(AMIDASE)		 1j31 HYPOTHETICAL PROTEIN
PH0642
(Pyrococcus
horikoshii) 		5 / 9 GLU A  42
TYR A  48
LYS A 113
GLU A 120
LEU A 172
 None
None
None
None
ACT  A1301 (-4.3A)
 0.91A 5ny7A-1j31A:
34.2		 5ny7A-1j31A:
27.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_A_TRPA501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 1j31 HYPOTHETICAL PROTEIN
PH0642
(Pyrococcus
horikoshii) 		5 / 10 ALA A  88
LEU A  16
TYR A  20
ASP A  45
VAL A  59
 None
 1.40A 5zbdA-1j31A:
0.0		 5zbdA-1j31A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_B_TRPB501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 1j31 HYPOTHETICAL PROTEIN
PH0642
(Pyrococcus
horikoshii) 		5 / 10 ALA A  88
LEU A  16
TYR A  20
ASP A  45
VAL A  59
 None
 1.40A 5zbdB-1j31A:
0.0		 5zbdB-1j31A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_B_TRPB502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 1j31 HYPOTHETICAL PROTEIN
PH0642
(Pyrococcus
horikoshii) 		5 / 10 ALA A  88
LEU A  16
TYR A  20
ASP A  45
VAL A  59
 None
 1.42A 6g2pB-1j31A:
0.0		 6g2pB-1j31A:
21.26