SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1j33'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ACJ_A_THAA999_1
(ACETYLCHOLINESTERASE)		 1j33 COBT
(Thermus
thermophilus) 		5 / 9 GLY A 102
GLU A 229
ILE A 165
HIS A  56
GLY A 164
 None
 1.27A 1acjA-1j33A:
2.2		 1acjA-1j33A:
20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1j33 COBT
(Thermus
thermophilus) 		6 / 8 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
GLY A 303
 None
 0.46A 1d0vA-1j33A:
47.1		 1d0vA-1j33A:
36.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 1j33 COBT
(Thermus
thermophilus) 		4 / 8 LEU A 113
HIS A 110
LEU A  76
LEU A  79
 None
 1.06A 1e7cA-1j33A:
undetectable		 1e7cA-1j33A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_C_BEZC1162_0
(PEROXIREDOXIN 5)		 1j33 COBT
(Thermus
thermophilus) 		5 / 9 PRO A 253
PRO A 281
GLY A 282
THR A 168
GLY A 190
 None
 1.34A 1h4oC-1j33A:
undetectable
1h4oD-1j33A:
undetectable		 1h4oC-1j33A:
19.17
1h4oD-1j33A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_E_BEZE1162_0
(PEROXIREDOXIN 5)		 1j33 COBT
(Thermus
thermophilus) 		5 / 9 PRO A 253
PRO A 281
GLY A 282
THR A 168
GLY A 190
 None
 1.37A 1h4oE-1j33A:
0.2
1h4oF-1j33A:
0.2		 1h4oE-1j33A:
19.17
1h4oF-1j33A:
19.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1j33 COBT
(Thermus
thermophilus) 		6 / 8 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
ARG A 279
 None
 0.97A 1jhaA-1j33A:
42.4		 1jhaA-1j33A:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1j33 COBT
(Thermus
thermophilus) 		6 / 8 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
GLY A 303
 None
 0.46A 1jhaA-1j33A:
42.4		 1jhaA-1j33A:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1j33 COBT
(Thermus
thermophilus) 		7 / 9 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
GLU A 280
ARG A 279
 None
 0.91A 1jhoA-1j33A:
44.1		 1jhoA-1j33A:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1j33 COBT
(Thermus
thermophilus) 		7 / 9 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
GLU A 280
GLY A 303
 None
 0.50A 1jhoA-1j33A:
44.1		 1jhoA-1j33A:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1j33 COBT
(Thermus
thermophilus) 		6 / 8 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
ARG A 279
 None
 0.98A 1jhqA-1j33A:
43.5		 1jhqA-1j33A:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1j33 COBT
(Thermus
thermophilus) 		6 / 8 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
GLY A 303
 None
 0.48A 1jhqA-1j33A:
43.5		 1jhqA-1j33A:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1j33 COBT
(Thermus
thermophilus) 		7 / 9 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
GLU A 280
ARG A 279
 None
 0.91A 1jhrA-1j33A:
46.8		 1jhrA-1j33A:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1j33 COBT
(Thermus
thermophilus) 		7 / 9 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
GLU A 280
GLY A 303
 None
 0.50A 1jhrA-1j33A:
46.8		 1jhrA-1j33A:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1j33 COBT
(Thermus
thermophilus) 		6 / 8 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
ARG A 279
 None
 1.01A 1jhvA-1j33A:
47.0		 1jhvA-1j33A:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1j33 COBT
(Thermus
thermophilus) 		6 / 8 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
GLY A 303
 None
 0.47A 1jhvA-1j33A:
47.0		 1jhvA-1j33A:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1j33 COBT
(Thermus
thermophilus) 		7 / 9 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
GLU A 280
ARG A 279
 None
 0.97A 1jhyA-1j33A:
47.2		 1jhyA-1j33A:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1j33 COBT
(Thermus
thermophilus) 		7 / 9 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
GLU A 280
GLY A 303
 None
 0.52A 1jhyA-1j33A:
47.2		 1jhyA-1j33A:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1j33 COBT
(Thermus
thermophilus) 		7 / 9 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
GLU A 280
ARG A 279
 None
 0.94A 1l4nA-1j33A:
46.9		 1l4nA-1j33A:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1j33 COBT
(Thermus
thermophilus) 		7 / 9 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
GLU A 280
GLY A 303
 None
 0.48A 1l4nA-1j33A:
46.9		 1l4nA-1j33A:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1j33 COBT
(Thermus
thermophilus) 		7 / 9 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
GLU A 280
ARG A 279
 None
 0.89A 1l5kA-1j33A:
42.3		 1l5kA-1j33A:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1j33 COBT
(Thermus
thermophilus) 		7 / 9 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
GLU A 280
GLY A 303
 None
 0.47A 1l5kA-1j33A:
42.3		 1l5kA-1j33A:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1j33 COBT
(Thermus
thermophilus) 		7 / 9 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
GLU A 280
ARG A 279
 None
 0.88A 1l5lA-1j33A:
47.0		 1l5lA-1j33A:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1j33 COBT
(Thermus
thermophilus) 		7 / 9 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
GLU A 280
GLY A 303
 None
 0.46A 1l5lA-1j33A:
47.0		 1l5lA-1j33A:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1j33 COBT
(Thermus
thermophilus) 		7 / 9 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
GLU A 280
ARG A 279
 None
 0.88A 1l5mA-1j33A:
46.7		 1l5mA-1j33A:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1j33 COBT
(Thermus
thermophilus) 		7 / 9 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
GLU A 280
GLY A 303
 None
 0.47A 1l5mA-1j33A:
46.7		 1l5mA-1j33A:
36.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1j33 COBT
(Thermus
thermophilus) 		5 / 12 GLY A 257
GLY A 305
GLY A 251
LEU A 302
ILE A  85
 None
 0.82A 2oxtB-1j33A:
undetectable		 2oxtB-1j33A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 1j33 COBT
(Thermus
thermophilus) 		5 / 12 ALA A 123
ILE A 228
GLY A 227
GLY A 226
VAL A 225
 None
 0.92A 3cyxB-1j33A:
undetectable		 3cyxB-1j33A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1j33 COBT
(Thermus
thermophilus) 		5 / 8 ASP A 250
GLY A 251
GLY A 257
LEU A 230
VAL A  51
 None
 1.26A 3em6A-1j33A:
undetectable		 3em6A-1j33A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1j33 COBT
(Thermus
thermophilus) 		5 / 11 GLY A 303
GLY A 251
PHE A 252
ASP A 250
ALA A 301
 None
 1.08A 3g88A-1j33A:
1.7		 3g88A-1j33A:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 1j33 COBT
(Thermus
thermophilus) 		4 / 6 LEU A 290
LYS A 263
ALA A 261
PRO A 266
 None
 1.35A 3gv1A-1j33A:
0.0
3gv1B-1j33A:
0.0		 3gv1A-1j33A:
17.26
3gv1B-1j33A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1j33 COBT
(Thermus
thermophilus) 		5 / 12 HIS A  56
TYR A 237
ALA A  54
GLY A 257
ALA A 256
 None
 0.96A 3ln1C-1j33A:
0.0		 3ln1C-1j33A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1j33 COBT
(Thermus
thermophilus) 		4 / 8 ARG A 316
LEU A 310
ALA A  91
ALA A  92
 None
 1.00A 3ns1L-1j33A:
0.0		 3ns1L-1j33A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 1j33 COBT
(Thermus
thermophilus) 		5 / 12 ALA A 204
ARG A 200
SER A  64
VAL A 225
ALA A 172
 None
 1.20A 3qxvE-1j33A:
undetectable		 3qxvE-1j33A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 1j33 COBT
(Thermus
thermophilus) 		5 / 11 LEU A 230
ALA A  52
ILE A 236
GLY A 305
ILE A 233
 None
 1.12A 3s53B-1j33A:
undetectable		 3s53B-1j33A:
14.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1j33 COBT
(Thermus
thermophilus) 		7 / 9 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
GLU A 280
ARG A 279
 None
 0.90A 4kqiA-1j33A:
47.1		 4kqiA-1j33A:
35.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1j33 COBT
(Thermus
thermophilus) 		7 / 9 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
GLU A 280
GLY A 303
 None
 0.50A 4kqiA-1j33A:
47.1		 4kqiA-1j33A:
35.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 1j33 COBT
(Thermus
thermophilus) 		5 / 12 ALA A 256
ASN A 167
ALA A  52
ILE A 236
ALA A 160
 None
 0.94A 4o2bD-1j33A:
3.5		 4o2bD-1j33A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 1j33 COBT
(Thermus
thermophilus) 		5 / 10 LEU A 290
LEU A 259
ALA A 258
HIS A 283
LEU A 249
 None
 1.08A 4p65A-1j33A:
undetectable
4p65B-1j33A:
undetectable
4p65F-1j33A:
undetectable
4p65H-1j33A:
undetectable		 4p65A-1j33A:
5.83
4p65B-1j33A:
5.52
4p65F-1j33A:
5.52
4p65H-1j33A:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 1j33 COBT
(Thermus
thermophilus) 		5 / 11 LEU A 290
LEU A 259
ALA A 258
LEU A 249
HIS A 283
 None
 1.07A 4p65C-1j33A:
undetectable
4p65D-1j33A:
undetectable
4p65J-1j33A:
undetectable
4p65L-1j33A:
undetectable		 4p65C-1j33A:
5.83
4p65D-1j33A:
5.52
4p65J-1j33A:
5.52
4p65L-1j33A:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 1j33 COBT
(Thermus
thermophilus) 		5 / 11 LEU A 249
HIS A 283
LEU A 290
LEU A 259
ALA A 258
 None
 1.05A 4p65B-1j33A:
undetectable
4p65D-1j33A:
undetectable
4p65G-1j33A:
undetectable
4p65H-1j33A:
undetectable		 4p65B-1j33A:
5.52
4p65D-1j33A:
5.52
4p65G-1j33A:
5.83
4p65H-1j33A:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1j33 COBT
(Thermus
thermophilus) 		5 / 9 ALA A 170
THR A 169
ALA A 173
GLY A  57
ALA A 130
 None
 1.09A 4qvnK-1j33A:
undetectable
4qvnL-1j33A:
undetectable		 4qvnK-1j33A:
19.30
4qvnL-1j33A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1j33 COBT
(Thermus
thermophilus) 		5 / 9 ALA A 170
THR A 169
ALA A 173
GLY A  57
ALA A 130
 None
 1.09A 4qvnY-1j33A:
undetectable
4qvnZ-1j33A:
undetectable		 4qvnY-1j33A:
19.30
4qvnZ-1j33A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1j33 COBT
(Thermus
thermophilus) 		5 / 9 ALA A 170
THR A 169
ALA A 173
GLY A  57
ALA A 130
 None
 1.10A 4qvqK-1j33A:
undetectable
4qvqL-1j33A:
undetectable		 4qvqK-1j33A:
19.30
4qvqL-1j33A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1j33 COBT
(Thermus
thermophilus) 		5 / 9 ALA A 170
THR A 169
ALA A 173
GLY A  57
ALA A 130
 None
 1.09A 4qvqY-1j33A:
undetectable
4qvqZ-1j33A:
undetectable		 4qvqY-1j33A:
19.30
4qvqZ-1j33A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1j33 COBT
(Thermus
thermophilus) 		5 / 12 LEU A 260
ALA A 256
ASN A 167
ALA A  52
ALA A 160
 None
 0.95A 4x20B-1j33A:
3.1		 4x20B-1j33A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 1j33 COBT
(Thermus
thermophilus) 		4 / 5 LEU A 230
ALA A  54
THR A  71
ILE A 165
 None
 0.95A 4xe3A-1j33A:
0.0		 4xe3A-1j33A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 1j33 COBT
(Thermus
thermophilus) 		4 / 5 LEU A 230
ALA A  54
THR A  71
ILE A 165
 None
 0.96A 4xe3B-1j33A:
0.0		 4xe3B-1j33A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 1j33 COBT
(Thermus
thermophilus) 		5 / 12 GLY A  47
ALA A 150
GLU A 153
ALA A  95
TYR A  97
 None
 1.32A 4ymgA-1j33A:
1.3		 4ymgA-1j33A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1j33 COBT
(Thermus
thermophilus) 		4 / 7 GLU A 135
GLY A 121
GLY A 227
ALA A 123
 None
 0.94A 5e26A-1j33A:
2.6
5e26B-1j33A:
2.2		 5e26A-1j33A:
24.14
5e26B-1j33A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 1j33 COBT
(Thermus
thermophilus) 		5 / 9 ALA A 170
THR A 169
ALA A 173
GLY A  57
ALA A 130
 None
 1.06A 5l5zK-1j33A:
undetectable
5l5zL-1j33A:
undetectable		 5l5zK-1j33A:
20.80
5l5zL-1j33A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 1j33 COBT
(Thermus
thermophilus) 		5 / 9 ALA A 170
THR A 169
ALA A 173
GLY A  57
ALA A 130
 None
 1.06A 5l5zY-1j33A:
undetectable
5l5zZ-1j33A:
undetectable		 5l5zY-1j33A:
20.80
5l5zZ-1j33A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 1j33 COBT
(Thermus
thermophilus) 		5 / 11 THR A 255
ALA A 256
GLY A 305
GLY A 161
ALA A 160
 None
 0.94A 5lf3K-1j33A:
undetectable
5lf3L-1j33A:
undetectable		 5lf3K-1j33A:
20.69
5lf3L-1j33A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 1j33 COBT
(Thermus
thermophilus) 		4 / 8 LEU A 249
LEU A 245
GLY A 244
TYR A 237
 None
 0.92A 6ce2A-1j33A:
undetectable		 6ce2A-1j33A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1j33 COBT
(Thermus
thermophilus) 		5 / 11 VAL A 248
ALA A 308
LEU A  44
ALA A 311
LEU A 295
 None
 1.46A 6dk1B-1j33A:
0.0		 6dk1B-1j33A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 1j33 COBT
(Thermus
thermophilus) 		4 / 7 ALA A  48
GLY A  47
LEU A 157
GLY A 305
 None
 0.86A 6nm4A-1j33A:
undetectable		 6nm4A-1j33A:
19.29