SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1j4a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4004_1
(SERUM ALBUMIN)		 1j4a D-LACTATE
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 4 VAL A 149
PHE A 161
SER A 204
VAL A 202
 None
 1.36A 1e7cA-1j4aA:
undetectable		 1e7cA-1j4aA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1j4a D-LACTATE
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 7 LEU A 293
ALA A 258
VAL A 232
VAL A 230
 None
 0.85A 1epbA-1j4aA:
undetectable		 1epbA-1j4aA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1j4a D-LACTATE
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 8 LEU A 293
ALA A 258
VAL A 232
VAL A 230
 None
 0.87A 1epbB-1j4aA:
0.0		 1epbB-1j4aA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1872_0
(FPRA)		 1j4a D-LACTATE
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 5 ASN A 316
ALA A 326
ASP A 315
GLU A 327
 None
 1.34A 1lqtA-1j4aA:
2.7
1lqtB-1j4aA:
3.3		 1lqtA-1j4aA:
24.27
1lqtB-1j4aA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1429_0
(FPRA)		 1j4a D-LACTATE
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 5 ASN A 316
ALA A 326
ASP A 315
GLU A 327
 None
 1.33A 1lquA-1j4aA:
5.1
1lquB-1j4aA:
undetectable		 1lquA-1j4aA:
24.27
1lquB-1j4aA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 1j4a D-LACTATE
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		5 / 10 LEU A  43
GLY A  46
ALA A  47
ASP A  48
THR A  32
 None
 0.98A 1t7iA-1j4aA:
undetectable		 1t7iA-1j4aA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1j4a D-LACTATE
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		3 / 3 VAL A 229
VAL A 232
ASP A 243
 None
 0.72A 2fumD-1j4aA:
undetectable		 2fumD-1j4aA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 1j4a D-LACTATE
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		3 / 3 SER A 204
HIS A 215
ASP A 243
 None
 0.75A 2wa2B-1j4aA:
undetectable		 2wa2B-1j4aA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1j4a D-LACTATE
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 8 LEU A  66
VAL A  50
GLY A  49
GLN A  95
 None
 0.74A 2wd9B-1j4aA:
3.8		 2wd9B-1j4aA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 1j4a D-LACTATE
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		5 / 10 GLY A 169
ALA A 170
VAL A 202
VAL A 151
VAL A 149
 None
 1.11A 3nu9B-1j4aA:
undetectable		 3nu9B-1j4aA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 1j4a D-LACTATE
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		5 / 10 LEU A  43
GLY A  46
ALA A  47
ASP A  48
THR A  32
 None
 0.90A 4njtB-1j4aA:
undetectable		 4njtB-1j4aA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 1j4a D-LACTATE
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		5 / 9 LEU A  43
GLY A  46
ALA A  47
ASP A  48
THR A  32
 None
 0.92A 4njtD-1j4aA:
undetectable		 4njtD-1j4aA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 1j4a D-LACTATE
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		5 / 12 VAL A 149
LEU A 119
ARG A 142
ILE A 118
ALA A 115
 None
 1.41A 5xprA-1j4aA:
0.0		 5xprA-1j4aA:
20.85