SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1j5s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		3 / 3 TRP A  44
ALA A  53
VAL A  50
 None
 0.93A 1av2C-1j5sA:
undetectable
1av2D-1j5sA:
undetectable		 1av2C-1j5sA:
5.24
1av2D-1j5sA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 5 THR A 151
ASP A 231
HIS A 290
HIS A  30
 None
 0.95A 1ei6A-1j5sA:
undetectable		 1ei6A-1j5sA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 8 THR A 151
ASP A 231
HIS A 290
HIS A  30
 None
 0.97A 1ei6C-1j5sA:
undetectable		 1ei6C-1j5sA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 8 THR A 151
ASP A 231
HIS A 290
HIS A  30
 None
 0.93A 1ei6D-1j5sA:
0.0		 1ei6D-1j5sA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		3 / 4 VAL A  58
TRP A 367
TRP A  59
 None
 1.37A 1gmkA-1j5sA:
undetectable
1gmkB-1j5sA:
undetectable		 1gmkA-1j5sA:
5.24
1gmkB-1j5sA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 8 LEU A 289
PHE A 327
LYS A 278
GLY A 277
 None
 0.80A 1os6A-1j5sA:
undetectable		 1os6A-1j5sA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 8 HIS A  30
ASP A  28
PHE A 404
ASP A 397
 None
 1.19A 1p7lC-1j5sA:
undetectable		 1p7lC-1j5sA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 8 HIS A  30
ASP A  28
PHE A 404
ASP A 397
 None
 1.19A 1p7lD-1j5sA:
undetectable		 1p7lD-1j5sA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 8 HIS A  30
ASP A  28
PHE A 404
ASP A 397
 None
 1.21A 1rg9A-1j5sA:
undetectable		 1rg9A-1j5sA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 8 HIS A  30
ASP A  28
PHE A 404
ASP A 397
 None
 1.20A 1rg9B-1j5sA:
undetectable		 1rg9B-1j5sA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 8 HIS A  30
ASP A  28
PHE A 404
ASP A 397
 None
 1.18A 1rg9C-1j5sA:
undetectable		 1rg9C-1j5sA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 8 HIS A  30
ASP A  28
PHE A 404
ASP A 397
 None
 1.18A 1rg9D-1j5sA:
undetectable		 1rg9D-1j5sA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		3 / 3 TRP A  44
ALA A  53
VAL A  50
 None
 0.97A 1w5uA-1j5sA:
undetectable
1w5uB-1j5sA:
undetectable		 1w5uA-1j5sA:
5.24
1w5uB-1j5sA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 5 LEU A 339
ILE A 291
ILE A 320
ALA A 321
 None
 0.68A 2i2zA-1j5sA:
undetectable		 2i2zA-1j5sA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		3 / 3 ALA A  53
VAL A  50
TRP A  44
 None
 0.81A 2izqA-1j5sA:
undetectable
2izqB-1j5sA:
undetectable		 2izqA-1j5sA:
5.24
2izqB-1j5sA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 8 TYR A 268
PRO A 154
PHE A 222
TRP A 177
 None
 1.42A 3bjwD-1j5sA:
undetectable		 3bjwD-1j5sA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		5 / 12 TYR A 340
GLY A 363
ALA A 364
ASP A 386
ALA A 354
 None
 1.05A 3id6C-1j5sA:
1.5		 3id6C-1j5sA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		3 / 3 ASP A 397
ARG A 407
ARG A 178
 None
 1.00A 3k37A-1j5sA:
undetectable		 3k37A-1j5sA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 5 ASN A  11
ALA A  14
ALA A  13
ARG A  16
 None
 1.15A 3kp2B-1j5sA:
0.0		 3kp2B-1j5sA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		3 / 3 TRP A  44
ALA A  53
VAL A  50
 None
 0.89A 3l8lA-1j5sA:
undetectable
3l8lB-1j5sA:
undetectable		 3l8lA-1j5sA:
5.24
3l8lB-1j5sA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 8 ASP A 296
ASP A 312
GLY A 310
ARG A 399
 None
 0.78A 3s3nA-1j5sA:
undetectable		 3s3nA-1j5sA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 8 LEU A 289
PHE A 327
LYS A 278
GLY A 277
 None
 0.81A 3selX-1j5sA:
undetectable		 3selX-1j5sA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 8 PRO A 237
HIS A 346
ILE A 291
ILE A 353
 None
 0.95A 3sfeB-1j5sA:
0.0
3sfeC-1j5sA:
0.0		 3sfeB-1j5sA:
19.79
3sfeC-1j5sA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 7 THR A 151
ASP A 231
HIS A 290
HIS A  30
 None
 0.93A 3t01A-1j5sA:
undetectable		 3t01A-1j5sA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 7 TYR A  57
ARG A 178
HIS A  30
HIS A  56
 None
 1.19A 3zodA-1j5sA:
undetectable		 3zodA-1j5sA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 8 ASP A 370
ASP A  55
ASN A  95
GLU A  99
 None
 1.06A 4feuD-1j5sA:
undetectable		 4feuD-1j5sA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 7 ASP A 370
ASP A  55
ASN A  95
GLU A  99
 None
 1.04A 4fevB-1j5sA:
0.0		 4fevB-1j5sA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 7 ASP A 370
ASP A  55
ASN A  95
GLU A  99
 None
 1.09A 4fewB-1j5sA:
0.3		 4fewB-1j5sA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 8 ASP A 370
ASP A  55
ASN A  95
GLU A  99
 None
 1.08A 4gkhD-1j5sA:
0.0		 4gkhD-1j5sA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 7 LEU A 289
PHE A 327
LYS A 278
GLY A 277
 None
 0.88A 4hajA-1j5sA:
undetectable		 4hajA-1j5sA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 8 LEU A 289
PHE A 327
LYS A 278
GLY A 277
 None
 0.78A 4hb6A-1j5sA:
undetectable		 4hb6A-1j5sA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 7 LEU A 289
PHE A 327
LYS A 278
GLY A 277
 None
 0.80A 4hbfA-1j5sA:
0.0		 4hbfA-1j5sA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 7 LEU A 289
PHE A 327
LYS A 278
GLY A 277
 None
 0.82A 4hc3A-1j5sA:
undetectable		 4hc3A-1j5sA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA408_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 6 TYR A 193
PRO A 179
PHE A 211
PHE A 276
 None
 1.42A 4kf9A-1j5sA:
0.0		 4kf9A-1j5sA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		3 / 3 ARG A 191
ASP A 204
ASP A 209
 None
 0.73A 4kicB-1j5sA:
0.8		 4kicB-1j5sA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 8 HIS A  30
ASP A  28
PHE A 404
ASP A 397
 None
 1.22A 4kttC-1j5sA:
undetectable		 4kttC-1j5sA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		5 / 11 MET A 279
LEU A 215
PHE A 211
HIS A 232
VAL A 239
 None
 1.43A 4mk4B-1j5sA:
0.4		 4mk4B-1j5sA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 8 PRO A 179
PHE A 222
PHE A 276
TRP A 285
 None
 1.39A 4v2zC-1j5sA:
undetectable		 4v2zC-1j5sA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		3 / 3 VAL A 145
LEU A 140
VAL A 171
 None
 0.56A 4wq4A-1j5sA:
0.9		 4wq4A-1j5sA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 5 PHE A 449
HIS A 439
LEU A 391
PRO A  29
 None
 1.44A 5csyB-1j5sA:
4.6		 5csyB-1j5sA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 7 ALA A  35
VAL A 168
LYS A 163
HIS A 161
 None
 1.01A 5ecnA-1j5sA:
0.1		 5ecnA-1j5sA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		4 / 6 HIS A 161
LEU A 158
CYH A 149
HIS A 225
 None
 1.22A 5hrqD-1j5sA:
undetectable
5hrqG-1j5sA:
undetectable
5hrqH-1j5sA:
undetectable		 5hrqD-1j5sA:
5.38
5hrqG-1j5sA:
4.12
5hrqH-1j5sA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1j5s URONATE ISOMERASE
(Thermotoga
maritima) 		5 / 12 ALA A 120
LEU A  83
MET A  62
GLY A  52
LEU A 131
 None
 1.24A 5x24A-1j5sA:
undetectable		 5x24A-1j5sA:
22.55