SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1j5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermotoga
maritima) 		5 / 9 ARG A   5
ILE A  83
PRO A  82
ALA A  55
ILE A  56
 None
 1.24A 1aj6A-1j5tA:
undetectable		 1aj6A-1j5tA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermotoga
maritima) 		4 / 7 GLU A 187
GLU A 135
ILE A 109
LEU A  59
 None
 1.47A 1q0yH-1j5tA:
undetectable
1q0yL-1j5tA:
undetectable		 1q0yH-1j5tA:
22.51
1q0yL-1j5tA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermotoga
maritima) 		5 / 12 LEU A  84
LEU A 207
GLY A 155
ASN A 157
ALA A 110
 None
 1.32A 2bm9B-1j5tA:
undetectable		 2bm9B-1j5tA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermotoga
maritima) 		4 / 5 LEU A  59
ALA A  29
ILE A  36
LYS A  86
 None
 0.96A 2othA-1j5tA:
undetectable		 2othA-1j5tA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermotoga
maritima) 		5 / 9 ARG A   9
LEU A 207
ILE A  56
ALA A  53
GLU A  12
 None
 1.26A 2v0mB-1j5tA:
0.0		 2v0mB-1j5tA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermotoga
maritima) 		5 / 12 ILE A 212
LEU A 222
ILE A  22
ALA A  53
LEU A 207
 None
 0.92A 3a50A-1j5tA:
undetectable		 3a50A-1j5tA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermotoga
maritima) 		4 / 6 LEU A 207
GLU A 187
ASN A 157
SER A  57
 None
 1.45A 3i9jB-1j5tA:
undetectable		 3i9jB-1j5tA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermotoga
maritima) 		5 / 12 GLU A 223
GLU A 224
ARG A  19
VAL A  20
ILE A  22
 None
 1.44A 3jayA-1j5tA:
0.0		 3jayA-1j5tA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermotoga
maritima) 		4 / 4 GLY A  67
GLU A  61
ASP A  35
ASP A  68
 None
 1.28A 3mb5A-1j5tA:
undetectable		 3mb5A-1j5tA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermotoga
maritima) 		4 / 8 VAL A 134
VAL A  95
TYR A 122
ILE A 121
 None
 1.06A 3remA-1j5tA:
undetectable		 3remA-1j5tA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermotoga
maritima) 		4 / 7 ARG A 200
GLY A 189
VAL A  20
VAL A 203
 None
 0.69A 3ufnB-1j5tA:
undetectable		 3ufnB-1j5tA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermotoga
maritima) 		5 / 11 SER A 229
VAL A 203
LEU A 199
GLU A 187
ALA A 186
 None
 1.04A 4e0fA-1j5tA:
undetectable		 4e0fA-1j5tA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermotoga
maritima) 		5 / 11 VAL A 203
LEU A 199
GLU A 187
ALA A 186
VAL A 184
 None
 1.09A 4e0fA-1j5tA:
undetectable		 4e0fA-1j5tA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermotoga
maritima) 		4 / 4 LEU A  59
ALA A  29
ILE A  36
LYS A  86
 None
 1.00A 4eixA-1j5tA:
0.0		 4eixA-1j5tA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermotoga
maritima) 		4 / 7 LEU A  97
ALA A 103
ASP A 104
ILE A  46
 None
 0.91A 4eyrA-1j5tA:
undetectable		 4eyrA-1j5tA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermotoga
maritima) 		5 / 10 LEU A 107
LEU A 133
LEU A 142
LEU A 174
VAL A 178
 None
 1.20A 4po0A-1j5tA:
undetectable		 4po0A-1j5tA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermotoga
maritima) 		5 / 12 ARG A   5
ILE A  83
PRO A  82
ALA A  55
ILE A  56
 None
 1.26A 4uroC-1j5tA:
undetectable		 4uroC-1j5tA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermotoga
maritima) 		4 / 8 ILE A 212
PHE A 221
VAL A 208
GLU A 224
 None
 1.01A 5dqyA-1j5tA:
undetectable		 5dqyA-1j5tA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermotoga
maritima) 		5 / 12 PHE A 146
VAL A 134
LEU A 142
LEU A 174
VAL A 136
 None
 1.17A 5im2A-1j5tA:
undetectable		 5im2A-1j5tA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermotoga
maritima) 		5 / 9 ILE A  58
ALA A  85
ILE A  83
PRO A  69
ALA A  74
 None
 1.13A 5mvmA-1j5tA:
0.0
5mvmE-1j5tA:
0.0		 5mvmA-1j5tA:
16.20
5mvmE-1j5tA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermotoga
maritima) 		4 / 6 TYR A  64
ASP A  68
GLY A  67
PHE A  65
 None
 0.91A 5nooC-1j5tA:
undetectable		 5nooC-1j5tA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermotoga
maritima) 		4 / 8 TYR A  64
ASP A  68
GLY A  67
PHE A  65
 None
 0.91A 5nooD-1j5tA:
undetectable		 5nooD-1j5tA:
21.95