SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1j5u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AV2_C_DVAC6_0 (GRAMICIDIN A)	1j5u	ARCHEASE, POSSIBLE CHAPERONE (Thermotoga maritima)	3 / 3	ALA A 62 VAL A 67 TRP A 70	None	0.81A	1av2C-1j5uA: undetectable 1av2D-1j5uA: undetectable	1av2C-1j5uA: 5.88 1av2D-1j5uA: 5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W5U_C_DVAC6_0 (GRAMICIDIN D)	1j5u	ARCHEASE, POSSIBLE CHAPERONE (Thermotoga maritima)	3 / 3	ALA A 62 VAL A 67 TRP A 70	None	0.82A	1w5uC-1j5uA: undetectable 1w5uD-1j5uA: undetectable	1w5uC-1j5uA: 5.88 1w5uD-1j5uA: 5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NRR_B_D16B520_1 (DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	1j5u	ARCHEASE, POSSIBLE CHAPERONE (Thermotoga maritima)	5 / 12	ALA A 62 PHE A 115 LEU A 113 ILE A 21 LEU A 108	None	1.22A	3nrrB-1j5uA: undetectable	3nrrB-1j5uA: 14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MVN_B_PFLB410_1 (PROTON-GATED ION CHANNEL)	1j5u	ARCHEASE, POSSIBLE CHAPERONE (Thermotoga maritima)	5 / 9	ILE A 71 ILE A 105 VAL A 67 TYR A 19 ILE A 36	None	1.39A	5mvnB-1j5uA: 0.0	5mvnB-1j5uA: 21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MVN_D_PFLD410_1 (PROTON-GATED ION CHANNEL)	1j5u	ARCHEASE, POSSIBLE CHAPERONE (Thermotoga maritima)	5 / 10	ILE A 71 ILE A 105 VAL A 67 TYR A 19 ILE A 36	None	1.38A	5mvnD-1j5uA: 0.0	5mvnD-1j5uA: 21.48

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1AV2_C_DVAC6_0","GRAMICIDIN A","1j5u","ARCHEASE, POSSIBLE CHAPERONE","Thermotoga maritima",3,"ALA A  62;VAL A  67;TRP A  70","None","0.81A","1av2C-1j5uA:undetectable;1av2D-1j5uA:undetectable","1av2C-1j5uA:5.88;1av2D-1j5uA:5.88"],["1W5U_C_DVAC6_0","GRAMICIDIN D","1j5u","ARCHEASE, POSSIBLE CHAPERONE","Thermotoga maritima",3,"ALA A  62;VAL A  67;TRP A  70","None","0.82A","1w5uC-1j5uA:undetectable;1w5uD-1j5uA:undetectable","1w5uC-1j5uA:5.88;1w5uD-1j5uA:5.88"],["3NRR_B_D16B520_1","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","1j5u","ARCHEASE, POSSIBLE CHAPERONE","Thermotoga maritima",5,"ALA A  62;PHE A 115;LEU A 113;ILE A  21;LEU A 108","None","1.22A","3nrrB-1j5uA:undetectable","3nrrB-1j5uA:14.51"],["5MVN_B_PFLB410_1","PROTON-GATED ION CHANNEL","1j5u","ARCHEASE, POSSIBLE CHAPERONE","Thermotoga maritima",5,"ILE A  71;ILE A 105;VAL A  67;TYR A  19;ILE A  36","None","1.39A","5mvnB-1j5uA:0.0","5mvnB-1j5uA:21.48"],["5MVN_D_PFLD410_1","PROTON-GATED ION CHANNEL","1j5u","ARCHEASE, POSSIBLE CHAPERONE","Thermotoga maritima",5,"ILE A  71;ILE A 105;VAL A  67;TYR A  19;ILE A  36","None","1.38A","5mvnD-1j5uA:0.0","5mvnD-1j5uA:21.48"]]