SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1j5w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 1j5w GLYCYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermotoga
maritima) 		4 / 7 SER A  42
SER A 117
ALA A 122
PHE A 142
 None
 1.09A 1fxvA-1j5wA:
0.0
1fxvB-1j5wA:
0.0		 1fxvA-1j5wA:
21.82
1fxvB-1j5wA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 1j5w GLYCYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermotoga
maritima) 		4 / 6 PHE A  40
ILE A 148
LYS A 270
ALA A 271
 None
 1.07A 1hk2A-1j5wA:
3.3		 1hk2A-1j5wA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1j5w GLYCYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermotoga
maritima) 		3 / 3 LEU A   3
VAL A   6
LEU A  10
 None
 0.53A 1mz9B-1j5wA:
undetectable		 1mz9B-1j5wA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1j5w GLYCYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermotoga
maritima) 		3 / 3 ARG A 163
VAL A 129
TRP A 130
 None
 1.19A 1qw6A-1j5wA:
undetectable		 1qw6A-1j5wA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1j5w GLYCYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermotoga
maritima) 		3 / 3 ARG A 163
VAL A 129
TRP A 130
 None
 1.14A 1qwcA-1j5wA:
undetectable		 1qwcA-1j5wA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1j5w GLYCYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermotoga
maritima) 		3 / 3 ARG A 163
VAL A 129
TRP A 130
 None
 1.17A 1vagA-1j5wA:
0.0		 1vagA-1j5wA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1j5w GLYCYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermotoga
maritima) 		3 / 3 ARG A 163
VAL A 129
TRP A 130
 None
 1.16A 1zviA-1j5wA:
0.0		 1zviA-1j5wA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 1j5w GLYCYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermotoga
maritima) 		4 / 7 TYR A 260
PHE A 213
ASP A 214
GLU A 217
 None
 1.16A 2qebA-1j5wA:
undetectable		 2qebA-1j5wA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 1j5w GLYCYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermotoga
maritima) 		4 / 8 ILE A 157
TRP A  14
PHE A  13
TYR A 159
 None
 1.49A 3ccfB-1j5wA:
undetectable		 3ccfB-1j5wA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1j5w GLYCYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermotoga
maritima) 		5 / 12 ASP A 107
TRP A 130
THR A 137
ILE A 136
SER A  95
 None
 1.46A 3g4lD-1j5wA:
undetectable		 3g4lD-1j5wA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1j5w GLYCYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermotoga
maritima) 		4 / 7 PHE A 139
ILE A  81
VAL A  79
TYR A 159
 None
 1.09A 3p6hA-1j5wA:
undetectable		 3p6hA-1j5wA:
18.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1j5w GLYCYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermotoga
maritima) 		7 / 8 ALA A  31
GLY A  32
THR A  33
GLN A  76
GLN A  78
GLU A 156
THR A 158
 None
 0.58A 3rglA-1j5wA:
38.8		 3rglA-1j5wA:
57.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 1j5w GLYCYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermotoga
maritima) 		4 / 6 ARG A 163
GLY A 160
GLU A 162
GLN A 138
 None
 1.26A 4g0vB-1j5wA:
4.0		 4g0vB-1j5wA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1j5w GLYCYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermotoga
maritima) 		3 / 3 ARG A 163
VAL A 129
TRP A 130
 None
 1.12A 5fvoA-1j5wA:
0.0		 5fvoA-1j5wA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 1j5w GLYCYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermotoga
maritima) 		3 / 3 LYS A  17
GLN A  89
ASN A  87
 None
 1.05A 5l2tA-1j5wA:
undetectable		 5l2tA-1j5wA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 1j5w GLYCYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermotoga
maritima) 		3 / 3 HIS A 241
ASN A 244
ALA A 248
 None
 0.37A 5n4tB-1j5wA:
undetectable		 5n4tB-1j5wA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 1j5w GLYCYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermotoga
maritima) 		4 / 6 LEU A 230
PRO A  36
HIS A  35
GLU A  22
 None
 1.02A 6pahA-1j5wA:
undetectable		 6pahA-1j5wA:
23.88