SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1j5x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Thermotoga
maritima) 		4 / 8 SER A 218
ALA A 232
PHE A 212
GLU A 217
 None
 0.94A 1dmiA-1j5xA:
0.0
1dmiB-1j5xA:
0.0		 1dmiA-1j5xA:
19.60
1dmiB-1j5xA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Thermotoga
maritima) 		4 / 7 MET A 225
SER A 230
ALA A 303
PHE A 205
 None
 1.20A 1fxvA-1j5xA:
0.0
1fxvB-1j5xA:
undetectable		 1fxvA-1j5xA:
21.62
1fxvB-1j5xA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Thermotoga
maritima) 		4 / 7 LEU A 324
GLU A 224
LEU A 220
GLU A 217
 None
 1.02A 1linA-1j5xA:
undetectable		 1linA-1j5xA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Thermotoga
maritima) 		5 / 12 LEU A 156
LEU A 159
LEU A 162
ALA A 163
LEU A  66
 None
 1.02A 1s9pC-1j5xA:
undetectable		 1s9pC-1j5xA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Thermotoga
maritima) 		5 / 12 ILE A  58
LEU A  54
PHE A 139
PHE A  18
VAL A  23
 None
 1.14A 2ygpA-1j5xA:
0.0		 2ygpA-1j5xA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Thermotoga
maritima) 		5 / 12 PHE A  45
GLY A  47
PRO A  74
ILE A 121
PHE A  62
 None
 1.03A 2zzmA-1j5xA:
2.1		 2zzmA-1j5xA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Thermotoga
maritima) 		5 / 12 PHE A  45
GLY A  47
PRO A  74
ILE A 121
PHE A  62
 None
 1.08A 2zznA-1j5xA:
2.3		 2zznA-1j5xA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Thermotoga
maritima) 		5 / 12 PHE A  45
GLY A  47
PRO A  74
ILE A 121
PHE A  62
 None
 1.07A 2zznB-1j5xA:
undetectable		 2zznB-1j5xA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Thermotoga
maritima) 		5 / 12 PHE A  45
LEU A 105
GLY A  47
ILE A  58
PHE A 139
 None
 1.16A 2zznB-1j5xA:
undetectable		 2zznB-1j5xA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Thermotoga
maritima) 		4 / 6 PHE A  93
PHE A  95
LEU A  54
PHE A 152
 None
 1.12A 3ablP-1j5xA:
undetectable
3ablW-1j5xA:
0.0		 3ablP-1j5xA:
21.80
3ablW-1j5xA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Thermotoga
maritima) 		4 / 5 PHE A  93
PHE A  95
LEU A  54
PHE A 152
 None
 1.36A 3ag3C-1j5xA:
0.0
3ag3J-1j5xA:
0.0		 3ag3C-1j5xA:
21.80
3ag3J-1j5xA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Thermotoga
maritima) 		4 / 7 PHE A 297
PHE A 184
SER A 181
TYR A 180
 None
 1.49A 3hggA-1j5xA:
0.0		 3hggA-1j5xA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Thermotoga
maritima) 		4 / 8 ILE A 155
MET A 154
PHE A  19
PHE A  22
 None
 0.93A 3ko0B-1j5xA:
undetectable
3ko0J-1j5xA:
undetectable		 3ko0B-1j5xA:
15.98
3ko0J-1j5xA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Thermotoga
maritima) 		4 / 8 ILE A 155
MET A 154
PHE A  19
PHE A  22
 None
 0.95A 3ko0K-1j5xA:
undetectable
3ko0S-1j5xA:
undetectable		 3ko0K-1j5xA:
15.98
3ko0S-1j5xA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Thermotoga
maritima) 		4 / 8 PHE A  22
ILE A 155
MET A 154
PHE A  19
 None
 0.90A 3ko0O-1j5xA:
undetectable
3ko0Q-1j5xA:
0.1		 3ko0O-1j5xA:
15.98
3ko0Q-1j5xA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Thermotoga
maritima) 		4 / 4 VAL A 141
PHE A  22
PHE A  19
VAL A 178
 None
 1.14A 3rv5C-1j5xA:
undetectable
3rv5D-1j5xA:
undetectable		 3rv5C-1j5xA:
14.46
3rv5D-1j5xA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Thermotoga
maritima) 		4 / 5 THR A 122
ILE A 123
GLU A 143
PHE A  18
 None
 1.46A 4acbC-1j5xA:
5.6		 4acbC-1j5xA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Thermotoga
maritima) 		4 / 6 SER A  51
GLU A 217
VAL A 328
THR A 327
 None
 1.32A 4lnxA-1j5xA:
0.0		 4lnxA-1j5xA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA303_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Thermotoga
maritima) 		4 / 4 LEU A 279
VAL A 278
GLU A 280
ARG A 268
 None
 1.18A 4ww7A-1j5xA:
0.0		 4ww7A-1j5xA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Thermotoga
maritima) 		5 / 11 PHE A  95
GLY A  49
LEU A 159
LEU A 156
PHE A 152
 None
 1.17A 4zmeA-1j5xA:
undetectable		 4zmeA-1j5xA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Thermotoga
maritima) 		4 / 6 PHE A  93
PHE A  95
LEU A  54
PHE A 152
 None
 1.18A 5b1bC-1j5xA:
0.0
5b1bJ-1j5xA:
undetectable		 5b1bC-1j5xA:
21.80
5b1bJ-1j5xA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Thermotoga
maritima) 		4 / 7 ALA A  92
THR A 118
LYS A 112
HIS A 116
 None
 1.22A 5ecnA-1j5xA:
1.0		 5ecnA-1j5xA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Thermotoga
maritima) 		4 / 6 LEU A  91
LEU A  66
PHE A  93
LEU A 162
 None
 1.01A 5gs4A-1j5xA:
0.0		 5gs4A-1j5xA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Thermotoga
maritima) 		4 / 5 PHE A  93
PHE A  95
LEU A  54
PHE A 152
 None
 1.32A 5wauC-1j5xA:
0.0
5wauJ-1j5xA:
0.0		 5wauC-1j5xA:
21.80
5wauJ-1j5xA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Thermotoga
maritima) 		4 / 5 PHE A  93
PHE A  95
LEU A  54
PHE A 152
 None
 1.32A 5wauc-1j5xA:
0.0
5wauj-1j5xA:
0.0		 5wauc-1j5xA:
21.80
5wauj-1j5xA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Thermotoga
maritima) 		4 / 6 TYR A  52
VAL A  46
ILE A  73
GLU A  77
 None
 1.01A 5z3jA-1j5xA:
undetectable		 5z3jA-1j5xA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Thermotoga
maritima) 		4 / 7 VAL A 214
PRO A 182
PHE A 185
PHE A 297
 None
 1.09A 6aycA-1j5xA:
undetectable		 6aycA-1j5xA:
13.60