SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1j5y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IHI_A_IU5A326_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 1j5y TRANSCRIPTIONAL
REGULATOR, BIOTIN
REPRESSOR FAMILY
(Thermotoga
maritima) 		5 / 10 VAL A  77
HIS A 146
VAL A  75
ILE A 150
LEU A  88
 None
NI  A 201 (-3.4A)
None
None
None
 1.31A 1ihiA-1j5yA:
undetectable		 1ihiA-1j5yA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 1j5y TRANSCRIPTIONAL
REGULATOR, BIOTIN
REPRESSOR FAMILY
(Thermotoga
maritima) 		3 / 3 LEU A 171
GLU A 164
ILE A 161
 None
 0.61A 3czhA-1j5yA:
0.1		 3czhA-1j5yA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1j5y TRANSCRIPTIONAL
REGULATOR, BIOTIN
REPRESSOR FAMILY
(Thermotoga
maritima) 		4 / 6 GLU A 173
ILE A 172
HIS A 148
VAL A  91
 None
None
NI  A 201 (-3.3A)
None
 1.09A 4ejwB-1j5yA:
5.7		 4ejwB-1j5yA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1j5y TRANSCRIPTIONAL
REGULATOR, BIOTIN
REPRESSOR FAMILY
(Thermotoga
maritima) 		4 / 8 VAL A  77
HIS A 146
VAL A  75
ILE A 150
 None
NI  A 201 (-3.4A)
None
None
 0.90A 4jq1B-1j5yA:
undetectable		 4jq1B-1j5yA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQA_A_ID8A401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1j5y TRANSCRIPTIONAL
REGULATOR, BIOTIN
REPRESSOR FAMILY
(Thermotoga
maritima) 		5 / 9 VAL A  77
HIS A 146
VAL A  75
ILE A 150
LEU A  88
 None
NI  A 201 (-3.4A)
None
None
None
 1.32A 4jqaA-1j5yA:
0.0		 4jqaA-1j5yA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQA_B_ID8B401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1j5y TRANSCRIPTIONAL
REGULATOR, BIOTIN
REPRESSOR FAMILY
(Thermotoga
maritima) 		5 / 9 VAL A  77
HIS A 146
VAL A  75
ILE A 150
LEU A  88
 None
NI  A 201 (-3.4A)
None
None
None
 1.25A 4jqaB-1j5yA:
undetectable		 4jqaB-1j5yA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_B_FLPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1j5y TRANSCRIPTIONAL
REGULATOR, BIOTIN
REPRESSOR FAMILY
(Thermotoga
maritima) 		5 / 9 VAL A  77
HIS A 146
VAL A  75
ILE A 150
LEU A  88
 None
NI  A 201 (-3.4A)
None
None
None
 1.26A 4jtqB-1j5yA:
0.0		 4jtqB-1j5yA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1j5y TRANSCRIPTIONAL
REGULATOR, BIOTIN
REPRESSOR FAMILY
(Thermotoga
maritima) 		4 / 8 ILE A  98
ARG A  73
LEU A 171
ILE A 161
 None
 0.74A 4xtaB-1j5yA:
undetectable		 4xtaB-1j5yA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1j5y TRANSCRIPTIONAL
REGULATOR, BIOTIN
REPRESSOR FAMILY
(Thermotoga
maritima) 		4 / 7 ILE A  98
ARG A  73
LEU A 171
ILE A 161
 None
 0.93A 4xumA-1j5yA:
undetectable		 4xumA-1j5yA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 1j5y TRANSCRIPTIONAL
REGULATOR, BIOTIN
REPRESSOR FAMILY
(Thermotoga
maritima) 		4 / 6 PRO A 106
ILE A 111
GLY A 109
TYR A 108
 None
 1.04A 6gqiA-1j5yA:
0.0		 6gqiA-1j5yA:
16.05