SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1j6o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		4 / 5 HIS A   4
HIS A  61
HIS A 126
ASP A 201
 None
 0.71A 1e9yB-1j6oA:
14.6		 1e9yB-1j6oA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		4 / 8 PHE A 168
ILE A 150
LEU A 138
VAL A 125
 None
 0.89A 1fslA-1j6oA:
undetectable		 1fslA-1j6oA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		5 / 6 HIS A   4
HIS A   6
HIS A  61
HIS A 126
ASP A 201
 None
 0.87A 1fweC-1j6oA:
14.7		 1fweC-1j6oA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		5 / 12 GLU A  90
HIS A  61
HIS A 126
HIS A 151
ASP A 201
 None
 0.94A 1ituA-1j6oA:
14.3		 1ituA-1j6oA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		5 / 12 HIS A  61
HIS A 126
HIS A 151
ASP A 201
PRO A 203
 None
 1.49A 1ituA-1j6oA:
14.3		 1ituA-1j6oA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		5 / 12 GLU A  90
HIS A  61
HIS A 126
HIS A 151
ASP A 201
 None
 0.96A 1ituB-1j6oA:
14.0		 1ituB-1j6oA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		5 / 12 HIS A  61
HIS A 126
HIS A 151
ASP A 201
PRO A 203
 None
 1.50A 1ituB-1j6oA:
14.0		 1ituB-1j6oA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		5 / 11 LEU A  76
PHE A  72
GLY A  59
GLY A  89
LEU A 115
 None
 0.92A 1mx1A-1j6oA:
undetectable		 1mx1A-1j6oA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		5 / 12 HIS A 126
GLU A  90
GLY A  92
ASP A  40
VAL A  36
 None
 1.29A 1n2xA-1j6oA:
undetectable		 1n2xA-1j6oA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		4 / 5 ASP A   2
LEU A 220
ALA A   5
LEU A   7
 None
 1.10A 1nh8A-1j6oA:
0.0		 1nh8A-1j6oA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		5 / 12 LEU A   7
ASP A 201
HIS A 151
SER A  57
VAL A  34
 None
 1.29A 1uobA-1j6oA:
undetectable		 1uobA-1j6oA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		5 / 11 ASP A 201
HIS A 151
VAL A 149
SER A  57
VAL A  34
 None
 1.49A 1uofA-1j6oA:
undetectable		 1uofA-1j6oA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		4 / 4 HIS A 126
GLU A  90
HIS A  61
HIS A  63
 None
 1.29A 1uttA-1j6oA:
undetectable		 1uttA-1j6oA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		4 / 4 HIS A 126
GLU A  90
HIS A  61
HIS A  63
 None
 1.32A 2ozrE-1j6oA:
undetectable		 2ozrE-1j6oA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		3 / 3 PRO A 144
PHE A 250
LYS A 146
 None
 1.10A 3bjwG-1j6oA:
0.0		 3bjwG-1j6oA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		4 / 6 ASP A  40
HIS A 126
HIS A  61
ASP A 201
 None
 0.94A 3c0zC-1j6oA:
undetectable		 3c0zC-1j6oA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		4 / 6 ASP A  64
HIS A 151
HIS A 126
ASP A 201
 None
 1.14A 3c0zC-1j6oA:
undetectable		 3c0zC-1j6oA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		3 / 3 CYH A 202
HIS A   4
PHE A 204
 None
 1.13A 3cr4X-1j6oA:
undetectable		 3cr4X-1j6oA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		5 / 12 THR A 243
THR A 242
LEU A 220
ILE A  28
LEU A 193
 None
 1.39A 3gwxB-1j6oA:
undetectable		 3gwxB-1j6oA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		5 / 12 GLY A 173
GLY A 174
VAL A 176
ARG A 128
ILE A 227
 None
 1.22A 3h52B-1j6oA:
undetectable		 3h52B-1j6oA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		5 / 9 LEU A 184
VAL A 191
ILE A 227
LEU A 231
ILE A 196
 None
 1.24A 3jw3B-1j6oA:
undetectable		 3jw3B-1j6oA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		4 / 5 ILE A 113
ARG A 139
THR A 140
GLU A 136
 None
 1.48A 3ny4A-1j6oA:
0.0		 3ny4A-1j6oA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R4X_A_PZAA598_0
(LACTOPEROXIDASE)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		4 / 5 PHE A  12
ARG A  16
PHE A  23
PRO A 217
 None
 1.50A 3r4xA-1j6oA:
0.0		 3r4xA-1j6oA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		5 / 12 GLN A 112
GLY A  92
ARG A 128
ILE A 127
VAL A 125
 None
 1.20A 4azsA-1j6oA:
undetectable		 4azsA-1j6oA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		5 / 12 ALA A 183
PHE A 153
ILE A 172
VAL A 188
ILE A 196
 None
 1.12A 4aztA-1j6oA:
undetectable		 4aztA-1j6oA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		5 / 12 GLN A 112
GLY A  92
ARG A 128
ILE A 127
VAL A 125
 None
 1.19A 4azwA-1j6oA:
undetectable		 4azwA-1j6oA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		4 / 5 HIS A   4
HIS A  61
HIS A 126
ASP A 201
 None
 0.68A 4h9mA-1j6oA:
13.7		 4h9mA-1j6oA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		5 / 6 HIS A   4
HIS A   6
HIS A  61
HIS A 126
ASP A 201
 None
 0.77A 4ubpC-1j6oA:
14.7		 4ubpC-1j6oA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		5 / 6 HIS A   6
HIS A  61
HIS A 126
HIS A 151
ASP A 201
 None
 1.14A 4ubpC-1j6oA:
14.7		 4ubpC-1j6oA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_A_ACTA301_0
(ANTIBODY FAB HEAVY
CHAIN)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		4 / 4 THR A 226
VAL A 176
PRO A 207
THR A 177
 None
 1.37A 5mthA-1j6oA:
0.0
5mthH-1j6oA:
0.0		 5mthA-1j6oA:
22.18
5mthH-1j6oA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		4 / 8 ASP A 201
HIS A   4
HIS A   6
ARG A  97
 None
 0.84A 5nekB-1j6oA:
4.7		 5nekB-1j6oA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		4 / 8 ASP A 201
HIS A   4
HIS A   6
ARG A  97
 None
 0.86A 5nekD-1j6oA:
4.0		 5nekD-1j6oA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		4 / 6 HIS A 151
ASP A  94
HIS A  63
HIS A  61
 None
 0.96A 5nelB-1j6oA:
undetectable
5nelC-1j6oA:
4.4		 5nelB-1j6oA:
20.34
5nelC-1j6oA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1j6o TATD-RELATED
DEOXYRIBONUCLEASE
(Thermotoga
maritima) 		5 / 12 VAL A  36
LEU A 205
HIS A   6
PRO A  62
GLY A  92
 None
 1.23A 5ogcB-1j6oA:
1.1		 5ogcB-1j6oA:
19.82