SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1j6u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		5 / 10 GLY A  12
SER A  14
LEU A  18
THR A  38
LEU A  41
 None
 1.27A 1a8uA-1j6uA:
undetectable		 1a8uA-1j6uA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		5 / 10 GLY A  12
SER A  14
LEU A  18
THR A  38
LEU A  41
 None
 1.25A 1a8uB-1j6uA:
2.2		 1a8uB-1j6uA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		5 / 12 LEU A 284
PRO A 286
VAL A 287
LEU A 127
PHE A 277
 None
 0.97A 1gseB-1j6uA:
undetectable		 1gseB-1j6uA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		4 / 6 HIS A 122
LEU A 127
LEU A 124
PRO A 131
 None
 1.29A 1hz4A-1j6uA:
0.0		 1hz4A-1j6uA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		4 / 8 ALA A  15
LEU A 135
GLU A 162
THR A 114
 None
 0.83A 1ie4B-1j6uA:
undetectable
1ie4D-1j6uA:
undetectable		 1ie4B-1j6uA:
16.67
1ie4D-1j6uA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		5 / 11 GLY A 180
LEU A 215
GLY A 109
HIS A 218
GLU A 198
 None
 1.34A 1iolA-1j6uA:
4.6		 1iolA-1j6uA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		5 / 12 HIS A 144
ILE A  46
ARG A  37
ALA A  39
TYR A  40
 None
 1.44A 1ki7B-1j6uA:
undetectable		 1ki7B-1j6uA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		5 / 12 VAL A 123
LEU A 288
LEU A 291
LEU A 271
TYR A 231
 None
 1.21A 1kw0A-1j6uA:
undetectable		 1kw0A-1j6uA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_2
(ADENOSINE KINASE)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		4 / 4 SER A 279
LEU A 284
TYR A 231
GLY A 281
 None
 1.40A 1liiA-1j6uA:
4.7		 1liiA-1j6uA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		5 / 12 VAL A 123
LEU A 288
LEU A 291
LEU A 271
TYR A 231
 None
 1.24A 1mmkA-1j6uA:
undetectable		 1mmkA-1j6uA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		5 / 11 VAL A 123
LEU A 288
LEU A 291
LEU A 271
TYR A 231
 None
 1.23A 1mmtA-1j6uA:
undetectable		 1mmtA-1j6uA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		3 / 3 ILE A  48
ILE A  46
THR A  35
 None
 0.48A 1rg7A-1j6uA:
3.3		 1rg7A-1j6uA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		5 / 10 LEU A  44
ALA A  17
GLY A   7
GLY A   9
ILE A  46
 None
 0.93A 1sdvA-1j6uA:
0.0		 1sdvA-1j6uA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		4 / 4 SER A 435
ILE A 431
VAL A 343
THR A 331
 None
 1.07A 1u70A-1j6uA:
4.2		 1u70A-1j6uA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		5 / 12 ALA A 363
ASP A 323
GLY A 358
PRO A 347
ILE A 325
 None
 0.89A 2r5pB-1j6uA:
undetectable		 2r5pB-1j6uA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		3 / 3 ASN A 420
ASN A 311
ARG A 240
 None
 0.74A 2rlcA-1j6uA:
0.0		 2rlcA-1j6uA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		3 / 3 GLY A  12
GLY A   7
GLY A  10
 None
 0.40A 3bogC-1j6uA:
undetectable		 3bogC-1j6uA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		5 / 12 PHE A 134
GLY A  12
GLY A 136
PHE A  93
ARG A  37
 None
 1.21A 3dlcA-1j6uA:
4.7		 3dlcA-1j6uA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		5 / 9 ALA A 363
ASP A 323
GLY A 358
PRO A 347
ILE A 325
 None
 1.04A 3ektB-1j6uA:
undetectable		 3ektB-1j6uA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		5 / 10 ALA A 363
ASP A 323
GLY A 358
PRO A 347
ILE A 325
 None
 0.98A 3em3B-1j6uA:
undetectable		 3em3B-1j6uA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		5 / 12 PHE A 345
VAL A 371
PRO A 409
SER A 434
VAL A 414
 None
 1.13A 3iw1A-1j6uA:
undetectable		 3iw1A-1j6uA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		5 / 12 ILE A 344
VAL A 343
GLY A 427
LEU A 424
PRO A 322
 None
 0.93A 3mb5A-1j6uA:
5.9		 3mb5A-1j6uA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		4 / 7 VAL A   6
VAL A  27
ILE A  48
ARG A  78
 None
 1.34A 3ms9B-1j6uA:
undetectable		 3ms9B-1j6uA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		5 / 10 ALA A 363
ASP A 323
GLY A 358
PRO A 347
ILE A 325
 None
 0.97A 3oxwD-1j6uA:
undetectable		 3oxwD-1j6uA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		4 / 7 LEU A 276
VAL A 287
TYR A 282
LEU A 124
 None
 1.15A 4b3qA-1j6uA:
2.7		 4b3qA-1j6uA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		4 / 7 THR A 230
LEU A 284
VAL A 208
VAL A 222
 None
 0.97A 4cp4A-1j6uA:
0.0		 4cp4A-1j6uA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		3 / 3 PHE A 134
VAL A 154
GLU A 104
 None
 0.75A 4fvqA-1j6uA:
0.0		 4fvqA-1j6uA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_A_LURA201_1
(TRANSTHYRETIN)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		4 / 4 LYS A 333
LEU A 366
ALA A 332
VAL A 422
 None
 1.48A 4ik6A-1j6uA:
0.0		 4ik6A-1j6uA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		3 / 3 SER A 161
ASP A 111
ASP A 323
 None
 0.92A 4mwzA-1j6uA:
5.0		 4mwzA-1j6uA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		4 / 5 ARG A 436
ASP A 316
GLU A 412
VAL A 371
 None
 1.40A 4nkvB-1j6uA:
0.0		 4nkvB-1j6uA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		3 / 3 GLU A 162
ILE A  64
ALA A  68
 None
 0.51A 4wnwB-1j6uA:
0.0		 4wnwB-1j6uA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		3 / 3 LEU A 271
ALA A 270
LEU A 233
 None
 0.46A 5uunB-1j6uA:
undetectable		 5uunB-1j6uA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		5 / 9 ILE A 175
SER A 195
SER A 217
GLY A 220
THR A 108
 None
 1.32A 6awpA-1j6uA:
0.0		 6awpA-1j6uA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		3 / 3 HIS A 320
HIS A 348
ARG A 349
 None
 1.02A 6b58A-1j6uA:
5.0		 6b58A-1j6uA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		5 / 7 ALA A 319
PHE A 336
ILE A 341
LEU A 329
ILE A 303
 None
 1.40A 6b5vA-1j6uA:
undetectable
6b5vB-1j6uA:
undetectable		 6b5vA-1j6uA:
9.21
6b5vB-1j6uA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC
(Thermotoga
maritima) 		5 / 12 VAL A 120
VAL A 273
ARG A 300
THR A 110
GLY A 109
 None
 1.13A 6brdC-1j6uA:
3.2		 6brdC-1j6uA:
11.30