SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1j85'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 1j85 YIBK
(Haemophilus
influenzae) 		5 / 10 LEU A  29
LEU A  97
MET A  98
ILE A  32
HIS A  60
 None
 1.26A 1pcgA-1j85A:
undetectable		 1pcgA-1j85A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 1j85 YIBK
(Haemophilus
influenzae) 		5 / 12 PHE A  99
GLY A 100
GLY A 105
ILE A 122
MET A 124
 None
 0.63A 1v2xA-1j85A:
16.2		 1v2xA-1j85A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 1j85 YIBK
(Haemophilus
influenzae) 		4 / 8 PHE A  54
LEU A  44
LEU A  31
LEU A  29
 None
 0.94A 2bfpB-1j85A:
2.5		 2bfpB-1j85A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 1j85 YIBK
(Haemophilus
influenzae) 		4 / 7 ARG A  59
THR A  15
ILE A  57
PHE A  54
 None
 1.25A 2jc9A-1j85A:
3.4		 2jc9A-1j85A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 1j85 YIBK
(Haemophilus
influenzae) 		5 / 12 LEU A  29
ASN A  14
LEU A  21
THR A  25
LEU A   6
 None
 1.37A 3fsuA-1j85A:
4.0		 3fsuA-1j85A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 1j85 YIBK
(Haemophilus
influenzae) 		5 / 11 GLY A 100
ILE A 122
MET A 124
SER A 130
SER A 136
 None
 0.95A 3gyqB-1j85A:
16.3		 3gyqB-1j85A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 1j85 YIBK
(Haemophilus
influenzae) 		9 / 12 ASN A  14
LEU A  78
GLY A 100
GLY A 105
ILE A 122
MET A 124
SER A 130
ASN A 132
SER A 136
 None
 1.00A 3nk7A-1j85A:
17.0		 3nk7A-1j85A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 1j85 YIBK
(Haemophilus
influenzae) 		8 / 12 ASN A  14
THR A  80
GLY A 100
ILE A 122
MET A 124
SER A 130
ASN A 132
SER A 136
 None
 0.80A 3nk7A-1j85A:
17.0		 3nk7A-1j85A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 1j85 YIBK
(Haemophilus
influenzae) 		7 / 12 GLY A 100
GLU A 102
GLY A 105
ILE A 122
MET A 124
SER A 130
ASN A 132
 None
 1.41A 3nk7A-1j85A:
17.0		 3nk7A-1j85A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 1j85 YIBK
(Haemophilus
influenzae) 		7 / 12 THR A  80
GLY A 100
GLU A 102
ILE A 122
MET A 124
SER A 130
ASN A 132
 None
 1.28A 3nk7A-1j85A:
17.0		 3nk7A-1j85A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 1j85 YIBK
(Haemophilus
influenzae) 		9 / 12 ASN A  14
LEU A  78
PHE A  99
GLY A 100
GLY A 105
ILE A 122
MET A 124
SER A 130
SER A 136
 None
 0.99A 3nk7B-1j85A:
17.0		 3nk7B-1j85A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 1j85 YIBK
(Haemophilus
influenzae) 		6 / 12 GLY A 100
GLU A 102
GLY A 105
ILE A 122
MET A 124
SER A 130
 None
 1.30A 3nk7B-1j85A:
17.0		 3nk7B-1j85A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 1j85 YIBK
(Haemophilus
influenzae) 		6 / 12 LEU A  78
PHE A  99
GLY A 100
GLU A  10
GLY A 105
SER A 136
 None
 1.33A 3nk7B-1j85A:
17.0		 3nk7B-1j85A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1j85 YIBK
(Haemophilus
influenzae) 		4 / 8 PHE A  66
HIS A  60
GLU A   8
ILE A 110
 None
 1.35A 4cx7A-1j85A:
undetectable
4cx7B-1j85A:
undetectable		 4cx7A-1j85A:
15.91
4cx7B-1j85A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1j85 YIBK
(Haemophilus
influenzae) 		4 / 8 PHE A  76
GLU A 143
SER A  87
ARG A  74
 None
 1.37A 4d32A-1j85A:
undetectable
4d32B-1j85A:
0.0		 4d32A-1j85A:
17.41
4d32B-1j85A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 1j85 YIBK
(Haemophilus
influenzae) 		4 / 7 ARG A 104
ASN A  14
GLU A 102
MET A 114
 None
 0.82A 4g0vA-1j85A:
undetectable		 4g0vA-1j85A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 1j85 YIBK
(Haemophilus
influenzae) 		4 / 6 ARG A 104
ASN A  14
GLU A 102
MET A 114
 None
 0.89A 4g0vB-1j85A:
undetectable		 4g0vB-1j85A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1j85 YIBK
(Haemophilus
influenzae) 		4 / 7 PHE A  76
GLU A 143
SER A  87
ARG A  74
 None
 1.38A 4k5jA-1j85A:
0.0
4k5jB-1j85A:
0.0		 4k5jA-1j85A:
15.54
4k5jB-1j85A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 1j85 YIBK
(Haemophilus
influenzae) 		4 / 7 PHE A  76
GLU A 143
SER A  87
ARG A  74
 None
 1.34A 5adlA-1j85A:
undetectable
5adlB-1j85A:
undetectable		 5adlA-1j85A:
15.54
5adlB-1j85A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1j85 YIBK
(Haemophilus
influenzae) 		5 / 12 TYR A  96
ILE A 110
LEU A 111
GLY A 100
PHE A  66
 None
 1.11A 5d4uA-1j85A:
undetectable		 5d4uA-1j85A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1j85 YIBK
(Haemophilus
influenzae) 		5 / 12 TYR A  96
ILE A 110
LEU A 111
GLY A 100
PHE A  66
 None
 1.07A 5d4uB-1j85A:
undetectable		 5d4uB-1j85A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1j85 YIBK
(Haemophilus
influenzae) 		4 / 7 PHE A  76
GLU A 143
SER A  87
ARG A  74
 None
 1.38A 5fj3A-1j85A:
undetectable
5fj3B-1j85A:
undetectable		 5fj3A-1j85A:
15.54
5fj3B-1j85A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 1j85 YIBK
(Haemophilus
influenzae) 		5 / 12 GLY A 100
GLY A 105
ILE A 122
SER A 130
LEU A 133
 None
 0.97A 5l0zA-1j85A:
18.9		 5l0zA-1j85A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1j85 YIBK
(Haemophilus
influenzae) 		4 / 6 SER A  87
ARG A  74
PHE A  76
GLU A 143
 None
 1.39A 5uo8A-1j85A:
0.0
5uo8B-1j85A:
0.0		 5uo8A-1j85A:
15.23
5uo8B-1j85A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1j85 YIBK
(Haemophilus
influenzae) 		4 / 7 PHE A  76
GLU A 143
SER A  87
ARG A  74
 None
 1.36A 5vv7A-1j85A:
undetectable
5vv7B-1j85A:
undetectable		 5vv7A-1j85A:
15.54
5vv7B-1j85A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1j85 YIBK
(Haemophilus
influenzae) 		4 / 7 PHE A  76
GLU A 143
SER A  87
ARG A  74
 None
 1.31A 5vvnA-1j85A:
undetectable
5vvnB-1j85A:
0.0		 5vvnA-1j85A:
15.54
5vvnB-1j85A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1j85 YIBK
(Haemophilus
influenzae) 		4 / 7 SER A  87
ARG A  74
PHE A  76
GLU A 143
 None
 1.39A 6av6A-1j85A:
0.0
6av6B-1j85A:
undetectable		 6av6A-1j85A:
16.25
6av6B-1j85A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1j85 YIBK
(Haemophilus
influenzae) 		4 / 7 SER A  87
ARG A  74
PHE A  76
GLU A 143
 None
 1.35A 6av7A-1j85A:
0.0
6av7B-1j85A:
0.0		 6av7A-1j85A:
16.25
6av7B-1j85A:
16.25