SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1j8m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1j8m SIGNAL RECOGNITION
54 KDA PROTEIN
(Acidianus
ambivalens) 		5 / 12 VAL F 106
GLY F 105
LEU F 218
GLY F 193
VAL F 262
 None
 0.84A 1fduA-1j8mF:
3.1		 1fduA-1j8mF:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1j8m SIGNAL RECOGNITION
54 KDA PROTEIN
(Acidianus
ambivalens) 		5 / 12 VAL F 106
GLY F 105
LEU F 218
GLY F 193
VAL F 262
 None
 0.86A 1fduC-1j8mF:
4.0		 1fduC-1j8mF:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 1j8m SIGNAL RECOGNITION
54 KDA PROTEIN
(Acidianus
ambivalens) 		5 / 8 ALA F 115
GLY F 149
ILE F 152
ILE F 183
ILE F 185
 None
 0.95A 1hshD-1j8mF:
undetectable		 1hshD-1j8mF:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1j8m SIGNAL RECOGNITION
54 KDA PROTEIN
(Acidianus
ambivalens) 		5 / 9 LEU F 118
VAL F 129
TYR F  99
GLY F 130
LEU F 103
 None
 1.20A 1lwfA-1j8mF:
0.0		 1lwfA-1j8mF:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1j8m SIGNAL RECOGNITION
54 KDA PROTEIN
(Acidianus
ambivalens) 		4 / 6 LEU F 103
LEU F 131
GLY F 130
ILE F 183
 None
 0.88A 1mt1G-1j8mF:
0.0
1mt1J-1j8mF:
0.0		 1mt1G-1j8mF:
11.03
1mt1J-1j8mF:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1j8m SIGNAL RECOGNITION
54 KDA PROTEIN
(Acidianus
ambivalens) 		4 / 7 ILE F 183
LEU F 103
LEU F 131
GLY F 130
 None
 0.87A 1mt1H-1j8mF:
undetectable
1mt1K-1j8mF:
undetectable		 1mt1H-1j8mF:
15.67
1mt1K-1j8mF:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1j8m SIGNAL RECOGNITION
54 KDA PROTEIN
(Acidianus
ambivalens) 		4 / 8 LEU F 103
LEU F 131
GLY F 130
ILE F 183
 None
 0.85A 1n13A-1j8mF:
0.0
1n13F-1j8mF:
undetectable		 1n13A-1j8mF:
11.03
1n13F-1j8mF:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1j8m SIGNAL RECOGNITION
54 KDA PROTEIN
(Acidianus
ambivalens) 		5 / 6 ILE F 220
VAL F 136
ILE F 207
ILE F 168
ASP F 187
 None
 1.37A 1uwhB-1j8mF:
undetectable		 1uwhB-1j8mF:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1j8m SIGNAL RECOGNITION
54 KDA PROTEIN
(Acidianus
ambivalens) 		5 / 9 PHE F  28
VAL F  76
LEU F  80
PHE F 289
LEU F  32
 None
 1.22A 1wrkA-1j8mF:
0.0
1wrkB-1j8mF:
undetectable		 1wrkA-1j8mF:
17.17
1wrkB-1j8mF:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 1j8m SIGNAL RECOGNITION
54 KDA PROTEIN
(Acidianus
ambivalens) 		5 / 12 ALA F 263
GLY F 257
GLY F 256
SER F  81
LEU F   7
 None
 0.88A 1ya4A-1j8mF:
undetectable		 1ya4A-1j8mF:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 1j8m SIGNAL RECOGNITION
54 KDA PROTEIN
(Acidianus
ambivalens) 		5 / 9 ILE F 246
ILE F 224
ASP F 221
GLY F 255
ALA F 258
 None
 1.29A 2dtjA-1j8mF:
undetectable
2dtjB-1j8mF:
undetectable		 2dtjA-1j8mF:
21.64
2dtjB-1j8mF:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1j8m SIGNAL RECOGNITION
54 KDA PROTEIN
(Acidianus
ambivalens) 		5 / 8 TYR F 229
GLY F 266
THR F 265
ALA F 264
ALA F 263
 None
 1.39A 2ej3C-1j8mF:
undetectable		 2ej3C-1j8mF:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_E_CUE801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 1j8m SIGNAL RECOGNITION
54 KDA PROTEIN
(Acidianus
ambivalens) 		4 / 4 LEU F  15
HIS F 294
HIS F 295
HIS F 296
 None
 1.23A 2oqeE-1j8mF:
0.0		 2oqeE-1j8mF:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1j8m SIGNAL RECOGNITION
54 KDA PROTEIN
(Acidianus
ambivalens) 		4 / 7 ILE F 183
LEU F 103
LEU F 131
GLY F 130
 None
 0.88A 2qqcD-1j8mF:
0.0
2qqcE-1j8mF:
undetectable		 2qqcD-1j8mF:
15.67
2qqcE-1j8mF:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1j8m SIGNAL RECOGNITION
54 KDA PROTEIN
(Acidianus
ambivalens) 		4 / 8 ILE F 183
LEU F 103
LEU F 131
GLY F 130
 None
 0.88A 2qqcH-1j8mF:
undetectable
2qqcK-1j8mF:
0.0		 2qqcH-1j8mF:
15.67
2qqcK-1j8mF:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1j8m SIGNAL RECOGNITION
54 KDA PROTEIN
(Acidianus
ambivalens) 		4 / 8 ILE F 183
LEU F 103
LEU F 131
GLY F 130
 None
 0.86A 2qqdB-1j8mF:
0.2
2qqdC-1j8mF:
0.0		 2qqdB-1j8mF:
15.67
2qqdC-1j8mF:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1j8m SIGNAL RECOGNITION
54 KDA PROTEIN
(Acidianus
ambivalens) 		4 / 7 VAL F 216
ILE F 211
TYR F 208
ILE F 207
 None
 0.95A 3hgxA-1j8mF:
undetectable		 3hgxA-1j8mF:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_G_TFPG201_1
(PROTEIN S100-A4)		 1j8m SIGNAL RECOGNITION
54 KDA PROTEIN
(Acidianus
ambivalens) 		5 / 9 GLY F 273
GLY F 110
ILE F 244
PHE F  84
PHE F 289
 None
 1.46A 3ko0F-1j8mF:
1.8
3ko0G-1j8mF:
1.8		 3ko0F-1j8mF:
15.46
3ko0G-1j8mF:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1j8m SIGNAL RECOGNITION
54 KDA PROTEIN
(Acidianus
ambivalens) 		5 / 8 HIS F 294
LEU F 293
ILE F  73
VAL F  76
LEU F  80
 None
 1.00A 3kp6A-1j8mF:
undetectable
3kp6B-1j8mF:
undetectable		 3kp6A-1j8mF:
19.87
3kp6B-1j8mF:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1j8m SIGNAL RECOGNITION
54 KDA PROTEIN
(Acidianus
ambivalens) 		4 / 6 ILE F  73
VAL F  76
LEU F  80
HIS F 294
 None
 0.80A 3kp6A-1j8mF:
0.0
3kp6B-1j8mF:
0.1		 3kp6A-1j8mF:
19.87
3kp6B-1j8mF:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 1j8m SIGNAL RECOGNITION
54 KDA PROTEIN
(Acidianus
ambivalens) 		4 / 6 THR F 113
GLY F 116
ILE F 152
LEU F 281
 None
 0.91A 4ac9C-1j8mF:
3.3		 4ac9C-1j8mF:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1j8m SIGNAL RECOGNITION
54 KDA PROTEIN
(Acidianus
ambivalens) 		4 / 6 THR F 113
GLY F 116
ILE F 152
LEU F 281
 None
 0.99A 4acbC-1j8mF:
3.1		 4acbC-1j8mF:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1j8m SIGNAL RECOGNITION
54 KDA PROTEIN
(Acidianus
ambivalens) 		4 / 6 ILE F  97
VAL F 129
LEU F 131
ILE F 184
 None
 0.80A 4asdA-1j8mF:
undetectable		 4asdA-1j8mF:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 1j8m SIGNAL RECOGNITION
54 KDA PROTEIN
(Acidianus
ambivalens) 		4 / 7 HIS F 296
GLU F  70
HIS F 295
GLU F  67
 None
 0.99A 4hvrA-1j8mF:
undetectable		 4hvrA-1j8mF:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1j8m SIGNAL RECOGNITION
54 KDA PROTEIN
(Acidianus
ambivalens) 		5 / 12 GLY F 133
ALA F 169
ILE F 101
LEU F 103
ALA F 141
 None
 0.91A 5bw4B-1j8mF:
2.1		 5bw4B-1j8mF:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1j8m SIGNAL RECOGNITION
54 KDA PROTEIN
(Acidianus
ambivalens) 		5 / 8 ILE F 220
VAL F 136
ILE F 207
ILE F 168
ASP F 187
 None
 1.41A 5hi2A-1j8mF:
undetectable		 5hi2A-1j8mF:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1j8m SIGNAL RECOGNITION
54 KDA PROTEIN
(Acidianus
ambivalens) 		5 / 10 LEU F 259
LEU F   4
ASP F   5
ILE F 246
GLY F 273
 None
 1.26A 6dm0B-1j8mF:
3.4
6dm0C-1j8mF:
3.5		 6dm0B-1j8mF:
13.68
6dm0C-1j8mF:
13.68