SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1j9l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1j9l STATIONARY PHASE
SURVIVAL PROTEIN
(Thermotoga
maritima) 		4 / 6 GLY A  10
ILE A  11
GLN A  12
SER A  66
 None
 0.76A 1rs7B-1j9lA:
0.0		 1rs7B-1j9lA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 1j9l STATIONARY PHASE
SURVIVAL PROTEIN
(Thermotoga
maritima) 		4 / 6 ILE A  16
ALA A  33
THR A  67
ALA A  78
 None
 0.86A 1w0gA-1j9lA:
0.0		 1w0gA-1j9lA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 1j9l STATIONARY PHASE
SURVIVAL PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A   4
GLY A 112
ALA A 113
VAL A  87
ILE A  90
 None
 0.96A 2ienB-1j9lA:
undetectable		 2ienB-1j9lA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)		 1j9l STATIONARY PHASE
SURVIVAL PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A 138
ALA A 139
GLY A  15
VAL A  91
ILE A 126
 None
 1.02A 2z54A-1j9lA:
undetectable		 2z54A-1j9lA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)		 1j9l STATIONARY PHASE
SURVIVAL PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A   4
GLY A 112
ALA A 113
VAL A  87
ILE A  90
 None
 0.96A 3cywB-1j9lA:
undetectable		 3cywB-1j9lA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_2
(HIV-1 PROTEASE)		 1j9l STATIONARY PHASE
SURVIVAL PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A   4
GLY A 112
ALA A 113
VAL A  87
ILE A  90
 None
 0.93A 3d20B-1j9lA:
undetectable		 3d20B-1j9lA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_3
(HIV-1 PROTEASE)		 1j9l STATIONARY PHASE
SURVIVAL PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A   4
GLY A 112
ALA A 113
VAL A  87
ILE A  90
 None
 0.96A 3k4vD-1j9lA:
undetectable		 3k4vD-1j9lA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1j9l STATIONARY PHASE
SURVIVAL PROTEIN
(Thermotoga
maritima) 		3 / 3 SER A 107
GLY A 108
THR A 109
 VO4  A 401 (-2.6A)
VO4  A 401 (-3.9A)
VO4  A 401 (-3.4A)
 0.09A 3k9wA-1j9lA:
3.2		 3k9wA-1j9lA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 1j9l STATIONARY PHASE
SURVIVAL PROTEIN
(Thermotoga
maritima) 		5 / 10 LEU A  19
ILE A 126
ALA A 125
THR A 109
VAL A  31
 None
None
None
VO4  A 401 (-3.4A)
None
 1.43A 3r9cA-1j9lA:
undetectable		 3r9cA-1j9lA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)		 1j9l STATIONARY PHASE
SURVIVAL PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A   4
GLY A 112
ALA A 113
VAL A  87
ILE A  90
 None
 0.93A 3tkwA-1j9lA:
undetectable		 3tkwA-1j9lA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1j9l STATIONARY PHASE
SURVIVAL PROTEIN
(Thermotoga
maritima) 		4 / 6 GLY A  10
ILE A  11
GLN A  12
SER A  66
 None
 0.85A 4kcnA-1j9lA:
0.0		 4kcnA-1j9lA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1j9l STATIONARY PHASE
SURVIVAL PROTEIN
(Thermotoga
maritima) 		5 / 12 ILE A 226
VAL A 224
GLY A 138
ALA A 139
LEU A 143
 None
 0.85A 4o1zA-1j9lA:
undetectable		 4o1zA-1j9lA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1j9l STATIONARY PHASE
SURVIVAL PROTEIN
(Thermotoga
maritima) 		3 / 3 ASP A  73
ASN A  80
SER A 111
 None
 0.86A 4obwA-1j9lA:
2.2		 4obwA-1j9lA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1j9l STATIONARY PHASE
SURVIVAL PROTEIN
(Thermotoga
maritima) 		5 / 12 ASP A 135
ASP A   9
GLY A  93
SER A  92
THR A   6
 None
CA  A1301 (-2.3A)
None
None
None
 1.21A 5hfjD-1j9lA:
undetectable		 5hfjD-1j9lA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1j9l STATIONARY PHASE
SURVIVAL PROTEIN
(Thermotoga
maritima) 		5 / 12 ASP A 135
ASP A   9
GLY A  93
SER A  92
THR A   6
 None
CA  A1301 (-2.3A)
None
None
None
 1.23A 5hfjE-1j9lA:
undetectable		 5hfjE-1j9lA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1j9l STATIONARY PHASE
SURVIVAL PROTEIN
(Thermotoga
maritima) 		5 / 8 VAL A   5
ILE A  16
VAL A  62
PHE A  30
VAL A  29
 None
 1.30A 5l94A-1j9lA:
undetectable		 5l94A-1j9lA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 1j9l STATIONARY PHASE
SURVIVAL PROTEIN
(Thermotoga
maritima) 		5 / 12 PRO A  34
VAL A  31
VAL A  32
LEU A  89
LEU A  23
 None
 1.31A 5tiwA-1j9lA:
2.1		 5tiwA-1j9lA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1j9l STATIONARY PHASE
SURVIVAL PROTEIN
(Thermotoga
maritima) 		5 / 12 SER A  44
GLY A 112
ALA A 113
SER A  39
HIS A 106
 None
None
None
CA  A1301 ( 2.5A)
None
 1.50A 5wbvB-1j9lA:
0.0		 5wbvB-1j9lA:
21.62