SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jal'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1jal YCHF PROTEIN
(Haemophilus
influenzae) 		5 / 12 GLY A 101
GLY A   6
PHE A  19
ARG A 179
GLU A 229
 None
 1.04A 3g8bB-1jalA:
0.0		 3g8bB-1jalA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 1jal YCHF PROTEIN
(Haemophilus
influenzae) 		4 / 6 ILE A 178
LEU A 183
GLU A 161
ALA A 190
 None
 0.79A 3r9sA-1jalA:
undetectable		 3r9sA-1jalA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RLB_B_VIBB187_1
(THIT)		 1jal YCHF PROTEIN
(Haemophilus
influenzae) 		5 / 12 ILE A 240
GLU A 210
GLY A  14
VAL A 236
ASN A 207
 None
 1.36A 3rlbB-1jalA:
0.0		 3rlbB-1jalA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1jal YCHF PROTEIN
(Haemophilus
influenzae) 		5 / 12 GLY A  75
GLY A  83
ALA A  80
ALA A 135
SER A 139
 None
 0.96A 3sudD-1jalA:
undetectable		 3sudD-1jalA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_B_ZPCB1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1jal YCHF PROTEIN
(Haemophilus
influenzae) 		5 / 12 PHE A 213
ILE A 205
ASN A 207
GLU A 243
VAL A 269
 None
 1.24A 4a97A-1jalA:
2.3
4a97B-1jalA:
2.3		 4a97A-1jalA:
22.05
4a97B-1jalA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1jal YCHF PROTEIN
(Haemophilus
influenzae) 		5 / 12 PHE A 213
ILE A 205
ASN A 207
GLU A 243
VAL A 269
 None
 1.22A 4a97B-1jalA:
2.3
4a97C-1jalA:
2.2		 4a97B-1jalA:
22.05
4a97C-1jalA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 1jal YCHF PROTEIN
(Haemophilus
influenzae) 		4 / 7 GLN A 280
THR A 294
THR A  66
THR A  97
 None
 1.07A 4mbsA-1jalA:
0.0		 4mbsA-1jalA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 1jal YCHF PROTEIN
(Haemophilus
influenzae) 		3 / 3 LEU A 137
MET A 177
TYR A 194
 None
 0.79A 4p6xG-1jalA:
0.0		 4p6xG-1jalA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1jal YCHF PROTEIN
(Haemophilus
influenzae) 		5 / 10 ALA A 301
THR A 300
ALA A 299
ALA A 304
ASP A 355
 None
 1.04A 4qvyK-1jalA:
undetectable
4qvyL-1jalA:
undetectable		 4qvyK-1jalA:
19.84
4qvyL-1jalA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1jal YCHF PROTEIN
(Haemophilus
influenzae) 		3 / 3 VAL A  13
ALA A 238
PHE A 107
 None
 0.92A 4w5nA-1jalA:
5.4		 4w5nA-1jalA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 1jal YCHF PROTEIN
(Haemophilus
influenzae) 		4 / 4 ILE A 125
ARG A 179
TYR A 204
GLU A 229
 None
 1.49A 4zzbD-1jalA:
undetectable		 4zzbD-1jalA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 1jal YCHF PROTEIN
(Haemophilus
influenzae) 		5 / 10 LEU A  22
GLY A 101
GLY A   6
LEU A 276
ALA A 272
 None
 1.04A 5l0zB-1jalA:
undetectable		 5l0zB-1jalA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 1jal YCHF PROTEIN
(Haemophilus
influenzae) 		5 / 9 ALA A 301
THR A 300
ALA A 299
ALA A 304
ASP A 355
 None
 0.91A 5l5zK-1jalA:
undetectable
5l5zL-1jalA:
undetectable		 5l5zK-1jalA:
19.89
5l5zL-1jalA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 1jal YCHF PROTEIN
(Haemophilus
influenzae) 		5 / 9 ALA A 301
THR A 300
ALA A 299
ALA A 304
ASP A 355
 None
 0.91A 5l5zY-1jalA:
undetectable
5l5zZ-1jalA:
undetectable		 5l5zY-1jalA:
19.89
5l5zZ-1jalA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 1jal YCHF PROTEIN
(Haemophilus
influenzae) 		5 / 12 PHE A  70
ILE A   7
THR A  67
ALA A 238
ALA A 245
 None
 1.16A 5vcgA-1jalA:
0.0		 5vcgA-1jalA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 1jal YCHF PROTEIN
(Haemophilus
influenzae) 		5 / 12 ALA A 301
PRO A 302
ILE A 350
ASP A 353
GLY A 354
 None
 1.26A 5wwsB-1jalA:
undetectable		 5wwsB-1jalA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1jal YCHF PROTEIN
(Haemophilus
influenzae) 		5 / 12 ILE A 205
LEU A 276
GLY A 273
THR A  97
ALA A 231
 None
 1.12A 5x5qB-1jalA:
undetectable		 5x5qB-1jalA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1jal YCHF PROTEIN
(Haemophilus
influenzae) 		3 / 3 LYS A  24
ASN A  20
SER A 242
 None
 1.20A 5yw0A-1jalA:
0.0		 5yw0A-1jalA:
21.01