SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jax'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 10 LEU A   5
ALA A  61
ASP A  60
ILE A  87
VAL A  69
 None
 1.06A 1d4yA-1jaxA:
undetectable		 1d4yA-1jaxA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  16
PHE A 140
LEU A  12
VAL A  98
VAL A 151
 None
 1.43A 1hrkB-1jaxA:
3.5		 1hrkB-1jaxA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		4 / 5 LEU A 167
VAL A   3
CYH A  65
ALA A  62
 None
 1.03A 1mz9D-1jaxA:
0.0		 1mz9D-1jaxA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		4 / 4 LEU A 167
VAL A   3
CYH A  65
ALA A  62
 None
 1.05A 1mz9E-1jaxA:
0.0		 1mz9E-1jaxA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 10 LEU A   5
ALA A  61
ASP A  60
ILE A  87
VAL A  69
 None
 0.94A 1t3rA-1jaxA:
undetectable		 1t3rA-1jaxA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 TYR A 109
ALA A 116
ILE A 118
ALA A 120
SER A 185
 None
 0.91A 1ve3A-1jaxA:
5.3		 1ve3A-1jaxA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 171
VAL A  69
LEU A   5
ALA A 137
PHE A 140
 None
 1.11A 2jj8C-1jaxA:
undetectable		 2jj8C-1jaxA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 11 LEU A   5
ALA A  61
ASP A  60
ILE A  87
VAL A  69
 None
 1.08A 2o4pA-1jaxA:
undetectable		 2o4pA-1jaxA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 8 ALA A  62
LEU A   6
LEU A  70
VAL A 119
ILE A  78
 None
 1.20A 2uxpA-1jaxA:
undetectable		 2uxpA-1jaxA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W03_A_ADNA1588_1
(ACSD)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 10 LEU A  12
HIS A 133
PRO A  96
ILE A 195
THR A 192
 None
 1.41A 2w03A-1jaxA:
0.6		 2w03A-1jaxA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 THR A  71
ILE A 135
GLY A  13
ALA A 137
VAL A  29
 None
 1.18A 2yvlC-1jaxA:
4.0		 2yvlC-1jaxA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 THR A  71
ILE A 135
GLY A  13
ALA A 137
VAL A  29
 None
 1.18A 2yvlD-1jaxA:
3.9		 2yvlD-1jaxA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		4 / 5 TYR A 109
THR A 108
PHE A 107
LEU A 194
 None
 1.38A 3qelC-1jaxA:
4.0		 3qelC-1jaxA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		4 / 6 LEU A  16
ALA A 141
ARG A  19
LEU A   5
 None
 1.14A 3rd0A-1jaxA:
undetectable		 3rd0A-1jaxA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		4 / 6 LEU A  16
ALA A  68
LEU A   6
THR A  71
 None
 1.00A 3rozA-1jaxA:
4.1		 3rozA-1jaxA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		4 / 5 LEU A 174
GLY A 173
PHE A 147
PHE A 140
 None
 0.93A 3smtA-1jaxA:
0.0		 3smtA-1jaxA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  30
ASN A  58
TYR A  44
ILE A  27
ALA A  17
 None
 1.05A 3uwlD-1jaxA:
0.0		 3uwlD-1jaxA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		4 / 7 ARG A  82
PRO A  99
SER A 110
TRP A  74
 None
 1.47A 4kmmA-1jaxA:
1.4		 4kmmA-1jaxA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		4 / 7 ILE A 135
PHE A 140
VAL A 151
ILE A 168
 None
 0.92A 4zzbC-1jaxA:
0.0
4zzbD-1jaxA:
0.0		 4zzbC-1jaxA:
20.81
4zzbD-1jaxA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 GLY A 208
TYR A  44
GLY A  30
GLY A   7
THR A 134
 None
 0.79A 5eqbA-1jaxA:
0.0		 5eqbA-1jaxA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 GLY A 208
LEU A  16
TYR A  44
GLY A   7
THR A 134
 None
 1.06A 5eskA-1jaxA:
undetectable		 5eskA-1jaxA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  30
GLY A   8
HIS A  25
VAL A 164
ILE A  67
 None
 0.97A 5wz1A-1jaxA:
4.0		 5wz1A-1jaxA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  30
GLY A   8
HIS A  25
VAL A 164
ILE A  67
 None
 0.94A 5wz1C-1jaxA:
3.7		 5wz1C-1jaxA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  30
GLY A   8
HIS A  25
VAL A 164
ILE A  67
 None
 1.00A 5wz1D-1jaxA:
3.6		 5wz1D-1jaxA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  30
GLY A   8
HIS A  25
VAL A 164
ILE A  67
 None
 0.94A 5wz1E-1jaxA:
4.0		 5wz1E-1jaxA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  30
GLY A   8
HIS A  25
VAL A 164
ILE A  67
 None
 1.00A 5wz1F-1jaxA:
3.6		 5wz1F-1jaxA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  30
GLY A   8
HIS A  25
VAL A 164
ILE A  67
 None
 0.98A 5wz1G-1jaxA:
3.7		 5wz1G-1jaxA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  30
GLY A   8
HIS A  25
VAL A 164
ILE A  67
 None
 0.98A 5wz1H-1jaxA:
3.9		 5wz1H-1jaxA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  30
GLY A   8
HIS A  25
VAL A 164
ILE A  67
 None
 0.92A 5wz2C-1jaxA:
4.0		 5wz2C-1jaxA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		4 / 6 ALA A  41
SER A  31
GLY A   7
THR A  71
 None
 0.87A 6f8cA-1jaxA:
undetectable		 6f8cA-1jaxA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 1jax CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		4 / 8 ALA A  37
GLY A   7
ALA A  61
GLU A  59
 None
 0.70A 6mdqA-1jaxA:
undetectable		 6mdqA-1jaxA:
16.04