SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jbk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1jbk CLPB PROTEIN
(Escherichia
coli) 		4 / 5 LEU A 259
VAL A 262
LEU A 266
GLN A 269
 None
 0.59A 1fbmE-1jbkA:
undetectable		 1fbmE-1jbkA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 1jbk CLPB PROTEIN
(Escherichia
coli) 		4 / 6 LEU A 245
GLY A 243
LYS A 163
TYR A 164
 None
 1.23A 1gtiC-1jbkA:
undetectable		 1gtiC-1jbkA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 1jbk CLPB PROTEIN
(Escherichia
coli) 		4 / 5 LEU A 245
GLY A 243
LYS A 163
TYR A 164
 None
 1.23A 1gtiF-1jbkA:
undetectable		 1gtiF-1jbkA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 1jbk CLPB PROTEIN
(Escherichia
coli) 		5 / 10 MET A 242
LEU A 245
ALA A 249
GLU A 254
MET A 283
 None
 1.18A 2ocfA-1jbkA:
undetectable		 2ocfA-1jbkA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 1jbk CLPB PROTEIN
(Escherichia
coli) 		5 / 11 LEU A 219
VAL A 216
ILE A 223
GLU A 217
ALA A 220
 None
 1.08A 2yy8A-1jbkA:
undetectable
2yy8B-1jbkA:
undetectable		 2yy8A-1jbkA:
24.68
2yy8B-1jbkA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 1jbk CLPB PROTEIN
(Escherichia
coli) 		4 / 4 VAL A 338
ASP A 278
LEU A 168
ARG A 183
 None
 1.31A 2ziaA-1jbkA:
1.7		 2ziaA-1jbkA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1jbk CLPB PROTEIN
(Escherichia
coli) 		3 / 3 GLY A 209
GLY A 211
THR A 213
 MG  A   1 (-4.0A)
MG  A   1 (-4.0A)
MG  A   1 ( 4.7A)
 0.45A 3si7B-1jbkA:
4.7		 3si7B-1jbkA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 1jbk CLPB PROTEIN
(Escherichia
coli) 		4 / 7 GLY A 296
ILE A 323
LEU A 280
PHE A 333
 None
 0.84A 4ejjD-1jbkA:
0.0		 4ejjD-1jbkA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1jbk CLPB PROTEIN
(Escherichia
coli) 		5 / 10 LEU A 259
THR A 165
LEU A 240
LEU A 275
LEU A 263
 None
 0.99A 4z91A-1jbkA:
0.0
4z91B-1jbkA:
0.0
4z91C-1jbkA:
0.0
4z91D-1jbkA:
0.0
4z91E-1jbkA:
0.0		 4z91A-1jbkA:
20.06
4z91B-1jbkA:
20.06
4z91C-1jbkA:
20.06
4z91D-1jbkA:
20.06
4z91E-1jbkA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1jbk CLPB PROTEIN
(Escherichia
coli) 		5 / 10 LEU A 275
LEU A 263
LEU A 259
THR A 165
LEU A 240
 None
 1.00A 4z91A-1jbkA:
0.0
4z91B-1jbkA:
0.0
4z91C-1jbkA:
0.0
4z91D-1jbkA:
0.0
4z91E-1jbkA:
0.0		 4z91A-1jbkA:
20.06
4z91B-1jbkA:
20.06
4z91C-1jbkA:
20.06
4z91D-1jbkA:
20.06
4z91E-1jbkA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 1jbk CLPB PROTEIN
(Escherichia
coli) 		5 / 11 MET A 242
LEU A 245
ALA A 249
GLU A 254
MET A 283
 None
 1.34A 4zn7B-1jbkA:
0.0		 4zn7B-1jbkA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1jbk CLPB PROTEIN
(Escherichia
coli) 		4 / 8 LEU A 299
PHE A 333
ILE A 323
GLY A 312
 None
 0.72A 5eseA-1jbkA:
undetectable		 5eseA-1jbkA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1jbk CLPB PROTEIN
(Escherichia
coli) 		5 / 10 LEU A 303
PRO A 301
GLY A 306
LEU A 299
LEU A 263
 None
 1.04A 5o96G-1jbkA:
undetectable
5o96H-1jbkA:
undetectable		 5o96G-1jbkA:
23.48
5o96H-1jbkA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1jbk CLPB PROTEIN
(Escherichia
coli) 		4 / 7 VAL A 216
VAL A 336
PRO A 202
GLY A 312
 None
 0.95A 5x80C-1jbkA:
0.0
5x80D-1jbkA:
0.2		 5x80C-1jbkA:
19.00
5x80D-1jbkA:
19.00