SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jc2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NKX_C_STRC601_2 (STEROID 17-ALPHA-HYDROXYLASE /17,20 LYASE)	1jc2	TROPONIN C, SKELETAL MUSCLE (Gallus gallus)	4 / 5	ILE A 115 ASP A 140 GLU A 135 VAL A 129	None	1.18A	4nkxC-1jc2A: undetectable	4nkxC-1jc2A: 11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NKX_D_STRD601_2 (STEROID 17-ALPHA-HYDROXYLASE /17,20 LYASE)	1jc2	TROPONIN C, SKELETAL MUSCLE (Gallus gallus)	4 / 5	ILE A 115 ASP A 140 GLU A 135 VAL A 129	None	1.18A	4nkxD-1jc2A: undetectable	4nkxD-1jc2A: 11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HIE_A_P06A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	1jc2	TROPONIN C, SKELETAL MUSCLE (Gallus gallus)	4 / 7	ILE A 134 GLY A 119 PHE A 102 PHE A 112	None	1.12A	5hieA-1jc2A: undetectable	5hieA-1jc2A: 13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HIE_D_P06D801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	1jc2	TROPONIN C, SKELETAL MUSCLE (Gallus gallus)	5 / 8	ILE A 134 GLY A 119 PHE A 102 ASP A 114 PHE A 112	None None None CA A 2 ( 4.6A) None	1.37A	5hieD-1jc2A: undetectable	5hieD-1jc2A: 13.33

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4NKX_C_STRC601_2","STEROID 17-ALPHA-HYDROXYLASE\/17,20 LYASE","1jc2","TROPONIN C, SKELETAL MUSCLE","Gallus gallus",4,"ILE A 115;ASP A 140;GLU A 135;VAL A 129","None","1.18A","4nkxC-1jc2A:undetectable","4nkxC-1jc2A:11.06"],["4NKX_D_STRD601_2","STEROID 17-ALPHA-HYDROXYLASE\/17,20 LYASE","1jc2","TROPONIN C, SKELETAL MUSCLE","Gallus gallus",4,"ILE A 115;ASP A 140;GLU A 135;VAL A 129","None","1.18A","4nkxD-1jc2A:undetectable","4nkxD-1jc2A:11.06"],["5HIE_A_P06A801_2","SERINE\/THREONINE-PROTEIN KINASE B-RAF","1jc2","TROPONIN C, SKELETAL MUSCLE","Gallus gallus",4,"ILE A 134;GLY A 119;PHE A 102;PHE A 112","None","1.12A","5hieA-1jc2A:undetectable","5hieA-1jc2A:13.33"],["5HIE_D_P06D801_2","SERINE\/THREONINE-PROTEIN KINASE B-RAF","1jc2","TROPONIN C, SKELETAL MUSCLE","Gallus gallus",5,"ILE A 134;GLY A 119;PHE A 102;ASP A 114;PHE A 112","None;None;None; CA A   2 ( 4.6A);None","1.37A","5hieD-1jc2A:undetectable","5hieD-1jc2A:13.33"]]