SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jcf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		5 / 9 ILE A   8
LEU A  80
GLU A 120
ALA A 123
VAL A  98
 None
 1.28A 1ctrA-1jcfA:
undetectable		 1ctrA-1jcfA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		5 / 12 LEU A 290
GLY A 287
GLY A 286
LEU A 312
ILE A 208
 None
 0.95A 1mx1D-1jcfA:
2.5		 1mx1D-1jcfA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		4 / 8 ASP A  72
ILE A  32
ILE A  41
GLY A  39
 None
 0.66A 1sh9A-1jcfA:
undetectable		 1sh9A-1jcfA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		5 / 12 ALA A 319
ARG A  97
LEU A  80
ILE A  84
MET A  65
 None
 1.16A 1y0xX-1jcfA:
undetectable		 1y0xX-1jcfA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		5 / 12 LEU A 128
GLY A 118
ASP A 116
ALA A 117
ALA A  76
 None
 1.18A 2br4E-1jcfA:
undetectable		 2br4E-1jcfA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		5 / 12 ILE A 210
GLY A 211
GLY A 244
GLU A 245
ILE A 208
 None
 0.98A 2fk8A-1jcfA:
undetectable		 2fk8A-1jcfA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		4 / 4 VAL A 161
ARG A 262
ILE A 303
THR A 159
 None
 1.30A 3cl9A-1jcfA:
undetectable		 3cl9A-1jcfA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		5 / 11 LEU A 332
ASP A 108
GLY A 105
ILE A 104
ILE A 129
 None
 1.12A 3ebzB-1jcfA:
undetectable		 3ebzB-1jcfA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		5 / 12 LEU A  16
GLY A 286
GLY A 285
ALA A  13
ASP A 180
 None
 1.12A 3i5uA-1jcfA:
undetectable		 3i5uA-1jcfA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		5 / 12 LEU A 323
ILE A  84
GLY A 122
ALA A 123
SER A 124
 None
 0.95A 3n8xB-1jcfA:
0.0		 3n8xB-1jcfA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		6 / 12 ARG A 111
LEU A 128
GLY A 118
PRO A 103
VAL A 102
ILE A 100
 None
 1.31A 3ndtB-1jcfA:
undetectable		 3ndtB-1jcfA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		5 / 12 ALA A  13
GLY A 287
ILE A 154
LEU A 250
GLU A 204
 None
 1.11A 3o7wA-1jcfA:
undetectable		 3o7wA-1jcfA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		5 / 8 GLY A 156
GLY A 155
ILE A 257
LEU A 290
VAL A 253
 None
 1.13A 3v1nA-1jcfA:
undetectable		 3v1nA-1jcfA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		5 / 8 GLY A 156
GLY A 155
ILE A 257
LEU A 293
VAL A 253
 None
 1.02A 3v1nA-1jcfA:
undetectable		 3v1nA-1jcfA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		5 / 8 GLY A 157
GLY A 155
ILE A 257
LEU A 290
VAL A 253
 None
 1.16A 3v1nA-1jcfA:
undetectable		 3v1nA-1jcfA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		5 / 12 GLY A 287
GLY A 286
GLY A 285
LEU A 293
VAL A 253
 None
 0.90A 4htfA-1jcfA:
undetectable		 4htfA-1jcfA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		5 / 12 GLY A 287
GLY A 286
GLY A 285
LEU A 293
VAL A 253
 None
 0.91A 4htfB-1jcfA:
undetectable		 4htfB-1jcfA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		5 / 12 LEU A 332
LEU A 128
ILE A 328
ILE A 137
LEU A 323
 None
 1.15A 4j24A-1jcfA:
undetectable		 4j24A-1jcfA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		5 / 12 LEU A  10
PRO A  64
ALA A  48
ILE A  84
GLY A 122
 None
 1.23A 4l9qB-1jcfA:
undetectable		 4l9qB-1jcfA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		4 / 6 ASP A  67
ASP A 180
SER A  30
ALA A  71
 None
 1.12A 4nedA-1jcfA:
undetectable		 4nedA-1jcfA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		4 / 6 GLU A 131
ASP A  67
GLU A 181
ARG A  63
 None
 1.28A 4ntxA-1jcfA:
0.0
4ntxC-1jcfA:
0.0		 4ntxA-1jcfA:
21.94
4ntxC-1jcfA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		5 / 10 GLY A 156
GLY A 179
GLU A 204
LYS A 207
GLY A 286
 None
 0.67A 5aqfA-1jcfA:
26.4		 5aqfA-1jcfA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		5 / 10 GLY A 156
GLY A 179
GLU A 204
LYS A 207
GLY A 286
 None
 0.66A 5aqfC-1jcfA:
26.4		 5aqfC-1jcfA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		5 / 10 GLY A 156
GLY A 179
GLU A 204
LYS A 207
GLY A 286
 None
 0.66A 5aqyA-1jcfA:
28.0		 5aqyA-1jcfA:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		5 / 6 SER A 174
GLU A 173
GLY A  11
ASP A   9
GLY A 156
 None
 1.28A 5cdnA-1jcfA:
0.0
5cdnB-1jcfA:
undetectable		 5cdnA-1jcfA:
22.95
5cdnB-1jcfA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		4 / 6 SER A 260
GLU A 259
GLY A 285
GLY A 287
 None
 0.83A 5cdnA-1jcfA:
0.0
5cdnB-1jcfA:
undetectable		 5cdnA-1jcfA:
22.95
5cdnB-1jcfA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		5 / 6 SER A 174
GLU A 173
GLY A  11
ASP A   9
GLY A 156
 None
 1.33A 5cdnR-1jcfA:
0.0
5cdnS-1jcfA:
2.0		 5cdnR-1jcfA:
22.95
5cdnS-1jcfA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		4 / 6 GLY A 157
ASP A 180
ARG A  66
GLY A  68
 None
 0.97A 5cdpA-1jcfA:
0.0
5cdpB-1jcfA:
2.3		 5cdpA-1jcfA:
23.25
5cdpB-1jcfA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		5 / 12 ARG A 201
GLY A  53
LEU A 231
GLY A 228
ILE A 198
 None
 1.06A 5vooA-1jcfA:
2.9		 5vooA-1jcfA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB
(Thermotoga
maritima) 		5 / 12 ARG A 201
GLY A  53
LEU A 231
GLY A 228
ILE A 198
 None
 1.06A 5vooC-1jcfA:
2.9		 5vooC-1jcfA:
23.65