SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jcm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE
(Escherichia
coli) 		5 / 9 ILE P 183
LEU P 201
GLU P 171
ALA P 173
VAL P 181
 None
 1.21A 1ctrA-1jcmP:
undetectable		 1ctrA-1jcmP:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE
(Escherichia
coli) 		4 / 7 SER P  85
VAL P 180
GLY P 182
ILE P 212
 None
 0.74A 1gtnC-1jcmP:
undetectable
1gtnD-1jcmP:
undetectable		 1gtnC-1jcmP:
15.06
1gtnD-1jcmP:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE
(Escherichia
coli) 		4 / 6 VAL P   4
LEU P   5
PHE P 116
MET P 137
 None
 1.21A 1x8vA-1jcmP:
0.0		 1x8vA-1jcmP:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE
(Escherichia
coli) 		4 / 5 LEU P  87
ALA P  57
ILE P  64
LYS P 114
 None
None
None
137  P 400 (-2.4A)
 1.00A 2othA-1jcmP:
undetectable		 2othA-1jcmP:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE
(Escherichia
coli) 		4 / 6 LEU P 234
GLU P 214
ASN P 184
SER P  85
 137  P 400 (-4.6A)
None
137  P 400 ( 4.8A)
None
 1.35A 3i9jB-1jcmP:
undetectable		 3i9jB-1jcmP:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE
(Escherichia
coli) 		5 / 12 VAL P 249
ARG P 251
LEU P  52
CYH P  54
PHE P  68
 None
 1.23A 3mnpA-1jcmP:
undetectable		 3mnpA-1jcmP:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE
(Escherichia
coli) 		3 / 3 GLU P 214
LEU P 161
LEU P 176
 None
 0.62A 3ohtA-1jcmP:
undetectable		 3ohtA-1jcmP:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE
(Escherichia
coli) 		3 / 3 GLU P 214
LEU P 161
LEU P 176
 None
 0.61A 3ohtB-1jcmP:
undetectable		 3ohtB-1jcmP:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE
(Escherichia
coli) 		4 / 4 PHE P  99
TYR P 129
ILE P  51
LEU P  52
 None
 1.38A 3sudA-1jcmP:
undetectable		 3sudA-1jcmP:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE
(Escherichia
coli) 		4 / 5 PHE P  99
TYR P 129
ILE P  51
LEU P  52
 None
 1.35A 3sueC-1jcmP:
undetectable		 3sueC-1jcmP:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE
(Escherichia
coli) 		3 / 3 GLN P  23
PHE P  28
TYR P 121
 None
 1.01A 3ucjA-1jcmP:
0.0		 3ucjA-1jcmP:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE
(Escherichia
coli) 		4 / 4 LEU P  87
ALA P  57
ILE P  64
LYS P 114
 None
None
None
137  P 400 (-2.4A)
 1.08A 4eixA-1jcmP:
0.0		 4eixA-1jcmP:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE
(Escherichia
coli) 		3 / 3 PHE P  68
ILE P  73
ASP P 244
 None
 0.73A 5cswA-1jcmP:
undetectable		 5cswA-1jcmP:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE
(Escherichia
coli) 		3 / 3 PHE P  68
ILE P  73
ASP P 244
 None
 0.69A 5cswB-1jcmP:
undetectable		 5cswB-1jcmP:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE
(Escherichia
coli) 		3 / 3 PRO P  34
ARG P 127
GLU P 157
 None
 0.96A 5j6hA-1jcmP:
0.0		 5j6hA-1jcmP:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE
(Escherichia
coli) 		5 / 9 VAL P 160
LEU P 138
GLY P 177
LEU P 176
VAL P 181
 None
 1.28A 6czmB-1jcmP:
0.0
6czmC-1jcmP:
0.0		 6czmB-1jcmP:
21.62
6czmC-1jcmP:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE
(Escherichia
coli) 		5 / 9 VAL P 160
LEU P 138
GLY P 177
LEU P 176
VAL P 181
 None
 1.28A 6czmD-1jcmP:
0.0
6czmE-1jcmP:
0.0		 6czmD-1jcmP:
21.62
6czmE-1jcmP:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 VAL P 160
LEU P 138
GLY P 177
LEU P 176
VAL P 181
 None
 1.26A 6czmE-1jcmP:
0.0
6czmF-1jcmP:
0.0		 6czmE-1jcmP:
21.62
6czmF-1jcmP:
21.62