SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jcn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		5 / 12 THR A  74
ASP A 274
ASP A 364
GLY A 387
MET A 385
 None
None
CPR  A 631 (-2.6A)
CPR  A 631 (-3.7A)
CPR  A 631 (-3.4A)
 1.31A 1d4fC-1jcnA:
undetectable		 1d4fC-1jcnA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		5 / 8 LEU A 460
GLY A  89
ILE A  66
PHE A 456
VAL A 457
 None
 1.46A 1d4sB-1jcnA:
undetectable		 1d4sB-1jcnA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		3 / 3 THR A  52
PRO A  64
THR A  63
 None
 0.94A 1dscC-1jcnA:
undetectable		 1dscC-1jcnA:
2.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		4 / 6 ALA A 308
LYS A 311
ASP A 315
ALA A 316
 None
 0.45A 1iwhA-1jcnA:
undetectable		 1iwhA-1jcnA:
16.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		7 / 11 ASP A 274
SER A 275
SER A 276
ASN A 303
ARG A 322
MET A 325
GLY A 326
 None
None
None
CPR  A 631 ( 4.5A)
CPR  A 631 (-4.0A)
None
None
 0.60A 1jr1A-1jcnA:
50.3		 1jr1A-1jcnA:
83.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		5 / 11 SER A 276
SER A 275
GLY A 251
THR A 252
GLN A 283
 None
 1.31A 1jr1A-1jcnA:
50.3		 1jr1A-1jcnA:
83.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		5 / 11 SER A 276
SER A 275
GLY A 251
THR A 252
GLY A 301
 None
 1.16A 1jr1A-1jcnA:
50.3		 1jr1A-1jcnA:
83.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		5 / 8 ASP A 274
SER A 276
ASN A 303
ARG A 322
GLY A 326
 None
None
CPR  A 631 ( 4.5A)
CPR  A 631 (-4.0A)
None
 0.34A 1jr1B-1jcnA:
50.3		 1jr1B-1jcnA:
83.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		5 / 8 ASP A 274
SER A 275
SER A 276
ASN A 303
GLY A 326
 None
None
None
CPR  A 631 ( 4.5A)
None
 0.35A 1me7A-1jcnA:
40.6		 1me7A-1jcnA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		5 / 10 ASP A 274
SER A 275
SER A 276
ASN A 303
GLY A 326
 None
None
None
CPR  A 631 ( 4.5A)
None
 0.33A 1mehA-1jcnA:
40.6		 1mehA-1jcnA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		4 / 8 ASP A 274
SER A 275
SER A 276
ASN A 303
 None
None
None
CPR  A 631 ( 4.5A)
 0.30A 1meiA-1jcnA:
40.6		 1meiA-1jcnA:
35.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		5 / 11 ALA A 391
VAL A 373
LEU A 377
MET A  70
LEU A  65
 None
None
None
CPR  A 631 ( 3.8A)
None
 1.16A 1rlbF-1jcnA:
0.1		 1rlbF-1jcnA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		5 / 10 LEU A 390
GLY A 387
LEU A 389
ILE A 367
LEU A  65
 None
CPR  A 631 (-3.7A)
None
None
None
 1.01A 2f8dA-1jcnA:
0.0		 2f8dA-1jcnA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		5 / 10 LEU A 390
GLY A 387
LEU A 389
ILE A 367
LEU A  65
 None
CPR  A 631 (-3.7A)
None
None
None
 1.06A 2f8dB-1jcnA:
undetectable		 2f8dB-1jcnA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		4 / 7 VAL A 350
ARG A 341
ASN A 303
GLY A 302
 None
None
CPR  A 631 ( 4.5A)
None
 0.92A 2y05A-1jcnA:
undetectable
2y05B-1jcnA:
undetectable		 2y05A-1jcnA:
21.76
2y05B-1jcnA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		5 / 12 LEU A 235
ILE A 461
LEU A  65
GLY A  87
GLY A  86
 None
 1.01A 3axzA-1jcnA:
0.0		 3axzA-1jcnA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		5 / 12 ILE A 461
ILE A 464
VAL A 374
LYS A 375
LEU A 389
 None
 1.18A 3em0B-1jcnA:
undetectable		 3em0B-1jcnA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		4 / 5 THR A 345
LYS A 349
GLU A 352
PHE A 490
 None
 1.28A 4ac9C-1jcnA:
2.3		 4ac9C-1jcnA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		4 / 5 ILE A 471
ALA A 473
MET A 482
ARG A 480
 None
 0.84A 4acaB-1jcnA:
2.6
4acaC-1jcnA:
2.3		 4acaB-1jcnA:
22.92
4acaC-1jcnA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		4 / 5 THR A 345
LYS A 349
GLU A 352
PHE A 490
 None
 1.35A 4acbC-1jcnA:
2.1		 4acbC-1jcnA:
22.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		6 / 8 ASP A 274
SER A 275
SER A 276
ASN A 303
ARG A 322
MET A 325
 None
None
None
CPR  A 631 ( 4.5A)
CPR  A 631 (-4.0A)
None
 0.19A 4af0A-1jcnA:
48.6		 4af0A-1jcnA:
56.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_B_MOAB1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		6 / 10 ASP A 274
SER A 275
SER A 276
ASN A 303
ARG A 322
MET A 325
 None
None
None
CPR  A 631 ( 4.5A)
CPR  A 631 (-4.0A)
None
 0.18A 4af0B-1jcnA:
48.6		 4af0B-1jcnA:
56.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		4 / 8 ASP A 274
SER A 275
SER A 276
ASN A 303
 None
None
None
CPR  A 631 ( 4.5A)
 0.79A 4fo4A-1jcnA:
40.2		 4fo4A-1jcnA:
32.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		4 / 8 SER A 276
SER A 275
THR A 252
GLY A 301
 None
 0.99A 4fo4A-1jcnA:
40.2		 4fo4A-1jcnA:
32.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		4 / 8 SER A 275
SER A 276
ASN A 303
GLY A 326
 None
None
CPR  A 631 ( 4.5A)
None
 0.50A 4fo4B-1jcnA:
39.9		 4fo4B-1jcnA:
32.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		5 / 9 SER A 275
SER A 276
ASN A 303
GLY A 326
ASP A 364
 None
None
CPR  A 631 ( 4.5A)
None
CPR  A 631 (-2.6A)
 0.54A 4fxsA-1jcnA:
41.9		 4fxsA-1jcnA:
38.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		4 / 8 THR A  63
ILE A  59
VAL A 107
LEU A 244
 None
 0.96A 4r38B-1jcnA:
undetectable		 4r38B-1jcnA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		5 / 11 LEU A 389
ILE A 367
GLY A 366
GLY A 328
LEU A 390
 None
None
CPR  A 631 (-3.8A)
CPR  A 631 (-3.0A)
None
 0.86A 5twjD-1jcnA:
undetectable		 5twjD-1jcnA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		3 / 3 ILE A 367
VAL A 384
PRO A  64
 None
 0.64A 5uunA-1jcnA:
undetectable		 5uunA-1jcnA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		5 / 12 LEU A 235
ILE A 461
LEU A  65
GLY A  87
GLY A  86
 None
 0.98A 5wyqB-1jcnA:
undetectable		 5wyqB-1jcnA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		5 / 12 VAL A 104
LEU A  55
LEU A  61
ALA A 248
LEU A 297
 None
 1.13A 6ew0B-1jcnA:
undetectable		 6ew0B-1jcnA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		5 / 12 VAL A 104
LEU A  55
LEU A  61
ALA A 248
LEU A 297
 None
 1.13A 6ew0D-1jcnA:
undetectable		 6ew0D-1jcnA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		5 / 12 VAL A 104
LEU A  55
LEU A  61
ALA A 248
LEU A 297
 None
 1.13A 6ew0H-1jcnA:
undetectable		 6ew0H-1jcnA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		5 / 12 VAL A 104
LEU A  55
LEU A  61
ALA A 248
LEU A 297
 None
 1.13A 6ew0I-1jcnA:
undetectable		 6ew0I-1jcnA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I
(Homo
sapiens) 		4 / 7 VAL A 323
ILE A 300
MET A  82
GLY A  86
 None
 0.84A 6hd6B-1jcnA:
undetectable		 6hd6B-1jcnA:
9.27