SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jct'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		6 / 12 GLY A 418
GLY A  58
GLY A 420
LEU A  65
GLU A  59
ILE A  40
 None
 1.41A 2oxtB-1jctA:
undetectable		 2oxtB-1jctA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		4 / 4 ARG A  62
GLY A  58
GLU A  59
SER A 347
 None
 1.24A 2xctS-1jctA:
undetectable
2xctU-1jctA:
undetectable		 2xctS-1jctA:
19.80
2xctU-1jctA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		5 / 12 VAL A 132
LEU A 136
LEU A  84
TYR A  80
ALA A 118
 None
 1.09A 3n8zB-1jctA:
0.0		 3n8zB-1jctA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		4 / 8 ASN A 289
HIS A 368
ASP A 366
GLU A 216
 GKR  A 499 ( 2.9A)
GKR  A 499 (-4.1A)
None
None
 1.03A 3sg9B-1jctA:
0.0		 3sg9B-1jctA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		3 / 3 TYR A 175
MET A 147
LEU A 348
 None
 0.94A 3vw1D-1jctA:
0.0		 3vw1D-1jctA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		5 / 12 PHE A 351
PHE A  36
LEU A 378
SER A 340
LEU A 413
 None
 1.12A 4dm8B-1jctA:
0.0		 4dm8B-1jctA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		5 / 12 VAL A 323
ALA A 118
LEU A 135
LEU A 136
LEU A  84
 None
 1.16A 4i1rA-1jctA:
undetectable		 4i1rA-1jctA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		4 / 8 HIS A 315
PRO A 314
ASP A 313
SER A 338
 None
 1.06A 4k0bB-1jctA:
undetectable		 4k0bB-1jctA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		4 / 8 HIS A 315
PRO A 314
ASP A 313
SER A 338
 None
 1.04A 4l7iB-1jctA:
undetectable		 4l7iB-1jctA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		4 / 5 ILE A 248
LEU A 252
GLU A 216
VAL A 188
 None
 1.02A 4nkxB-1jctA:
0.0		 4nkxB-1jctA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		5 / 12 ALA A 357
ALA A 358
GLN A 141
LEU A 136
HIS A 339
 None
 1.14A 4nqaH-1jctA:
undetectable		 4nqaH-1jctA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		5 / 12 VAL A 132
LEU A 136
LEU A  84
TYR A  80
ALA A 118
 None
 1.01A 4rrxA-1jctA:
undetectable		 4rrxA-1jctA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		5 / 12 VAL A 132
LEU A 136
LEU A  84
TYR A  80
ALA A 118
 None
 1.06A 4rrxB-1jctA:
undetectable		 4rrxB-1jctA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		4 / 6 LEU A 206
LEU A 191
VAL A 188
PHE A 152
 None
None
None
GKR  A 499 (-4.7A)
 1.03A 4uswA-1jctA:
0.0		 4uswA-1jctA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		4 / 5 ARG A  62
GLY A  58
GLU A  59
SER A 347
 None
 1.06A 4z3oA-1jctA:
undetectable
4z3oB-1jctA:
undetectable		 4z3oA-1jctA:
20.41
4z3oB-1jctA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		4 / 6 SER A 347
ARG A  62
GLY A  58
GLU A  59
 None
 1.07A 5btaA-1jctA:
0.0
5btaB-1jctA:
undetectable
5btaC-1jctA:
0.0		 5btaA-1jctA:
23.39
5btaB-1jctA:
21.21
5btaC-1jctA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		4 / 5 SER A 347
ARG A  62
GLY A  58
GLU A  59
 None
 0.83A 5cdqA-1jctA:
0.0
5cdqB-1jctA:
undetectable
5cdqC-1jctA:
0.0		 5cdqA-1jctA:
21.69
5cdqB-1jctA:
19.86
5cdqC-1jctA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		4 / 5 SER A 347
ARG A  62
GLY A  58
GLU A  59
 None
 0.83A 5cdqR-1jctA:
undetectable
5cdqS-1jctA:
undetectable
5cdqT-1jctA:
0.0		 5cdqR-1jctA:
21.69
5cdqS-1jctA:
19.86
5cdqT-1jctA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		4 / 8 VAL A 132
LEU A 136
LEU A  84
ALA A 118
 None
 0.79A 5f1aA-1jctA:
0.0		 5f1aA-1jctA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		4 / 7 VAL A 132
LEU A  84
TYR A  80
ALA A 118
 None
 0.82A 5f1aB-1jctA:
0.0		 5f1aB-1jctA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		3 / 3 TRP A 240
GLU A 216
ASP A 235
 None
None
MG  A 498 ( 2.6A)
 0.53A 5gqbA-1jctA:
5.2		 5gqbA-1jctA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		4 / 4 ASN A 289
LEU A 311
SER A 340
LEU A 148
 GKR  A 499 ( 2.9A)
None
None
None
 1.29A 5kb5A-1jctA:
1.0		 5kb5A-1jctA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		4 / 8 ASP A  22
TYR A 164
PHE A 152
SER A  29
 None
None
GKR  A 499 (-4.7A)
None
 1.12A 5l1fA-1jctA:
undetectable
5l1fB-1jctA:
undetectable		 5l1fA-1jctA:
20.20
5l1fB-1jctA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		4 / 7 LEU A  28
ILE A 220
GLU A 216
ASP A 235
 None
None
None
MG  A 498 ( 2.6A)
 0.87A 5n5dA-1jctA:
undetectable		 5n5dA-1jctA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		4 / 5 HIS A  32
ASP A 235
GLY A 208
ASN A  27
 GKR  A 499 (-4.0A)
MG  A 498 ( 2.6A)
None
GKR  A 499 (-3.5A)
 1.15A 5x7pB-1jctA:
0.0		 5x7pB-1jctA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		4 / 4 PRO A  70
MET A 120
GLY A  51
VAL A  10
 None
 1.34A 6ak3A-1jctA:
0.0		 6ak3A-1jctA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		3 / 3 ARG A  99
LYS A 207
ARG A 107
 None
GKR  A 499 (-3.1A)
None
 1.40A 6az3C-1jctA:
0.0
6az3L-1jctA:
0.0
6az3M-1jctA:
undetectable		 6az3C-1jctA:
9.86
6az3L-1jctA:
10.02
6az3M-1jctA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		4 / 5 LEU A 378
THR A  37
PRO A 163
ARG A 157
 None
 0.97A 6ew0F-1jctA:
3.1		 6ew0F-1jctA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		4 / 6 LEU A 378
THR A  37
PRO A 163
ARG A 157
 None
 0.97A 6ew0G-1jctA:
3.1		 6ew0G-1jctA:
11.78