SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jd5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1jd5 APOPTOSIS 1
INHIBITOR
(Drosophila
melanogaster) 		3 / 3 PRO A 237
GLY A 258
TYR A 254
 None
 0.67A 2vouA-1jd5A:
undetectable		 2vouA-1jd5A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1jd5 APOPTOSIS 1
INHIBITOR
(Drosophila
melanogaster) 		3 / 3 PRO A 237
GLY A 258
TYR A 254
 None
 0.69A 2vouB-1jd5A:
undetectable		 2vouB-1jd5A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1jd5 APOPTOSIS 1
INHIBITOR
(Drosophila
melanogaster) 		3 / 3 PRO A 237
GLY A 258
TYR A 254
 None
 0.68A 2vouC-1jd5A:
undetectable		 2vouC-1jd5A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 1jd5 APOPTOSIS 1
INHIBITOR
(Drosophila
melanogaster) 		4 / 5 GLY A 251
ALA A 248
PHE A 264
GLU A 226
 None
 1.03A 4m93B-1jd5A:
undetectable
4m93C-1jd5A:
undetectable		 4m93B-1jd5A:
18.18
4m93C-1jd5A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_B_QDNB602_1
(CYTOCHROME P450 2D6)		 1jd5 APOPTOSIS 1
INHIBITOR
(Drosophila
melanogaster) 		5 / 9 LEU A 270
GLU A 314
GLN A 282
ALA A 284
ALA A 306
 None
 1.33A 4wnuB-1jd5A:
0.0		 4wnuB-1jd5A:
16.31