SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1je5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1je5 HELIX-DESTABILIZING
PROTEIN
(Escherichia
virus
T7) 		5 / 11 PHE A  96
ASN A  46
THR A 103
ASN A  99
VAL A  59
 None
 1.48A 2gl0B-1je5A:
0.0
2gl0C-1je5A:
0.0		 2gl0B-1je5A:
20.57
2gl0C-1je5A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1je5 HELIX-DESTABILIZING
PROTEIN
(Escherichia
virus
T7) 		5 / 12 ASN A  46
THR A 103
ASN A  99
VAL A  59
PHE A  96
 None
 1.50A 2gl0A-1je5A:
0.0
2gl0C-1je5A:
0.0		 2gl0A-1je5A:
20.57
2gl0C-1je5A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1je5 HELIX-DESTABILIZING
PROTEIN
(Escherichia
virus
T7) 		5 / 12 PHE A  96
ASN A  46
THR A 103
ASN A  99
VAL A  59
 None
 1.46A 2gl0D-1je5A:
0.0
2gl0E-1je5A:
undetectable		 2gl0D-1je5A:
20.57
2gl0E-1je5A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_E_ADNE905_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1je5 HELIX-DESTABILIZING
PROTEIN
(Escherichia
virus
T7) 		5 / 11 PHE A  96
ASN A  46
THR A 103
ASN A  99
VAL A  59
 None
 1.45A 2gl0E-1je5A:
undetectable
2gl0F-1je5A:
0.0		 2gl0E-1je5A:
20.57
2gl0F-1je5A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_F_ADNF906_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1je5 HELIX-DESTABILIZING
PROTEIN
(Escherichia
virus
T7) 		5 / 11 ASN A  46
THR A 103
ASN A  99
VAL A  59
PHE A  96
 None
 1.46A 2gl0D-1je5A:
0.0
2gl0F-1je5A:
0.0		 2gl0D-1je5A:
20.57
2gl0F-1je5A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 1je5 HELIX-DESTABILIZING
PROTEIN
(Escherichia
virus
T7) 		4 / 7 VAL A  37
ARG A  35
ASN A  26
GLY A  30
 None
 0.87A 2y05A-1je5A:
undetectable
2y05B-1je5A:
undetectable		 2y05A-1je5A:
22.19
2y05B-1je5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1je5 HELIX-DESTABILIZING
PROTEIN
(Escherichia
virus
T7) 		4 / 5 ILE A  44
PHE A 106
ASP A  41
GLU A  14
 None
 1.17A 3kp6A-1je5A:
undetectable
3kp6B-1je5A:
0.0		 3kp6A-1je5A:
19.52
3kp6B-1je5A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 1je5 HELIX-DESTABILIZING
PROTEIN
(Escherichia
virus
T7) 		3 / 3 TYR A 153
ARG A  50
SER A   8
 None
 1.16A 4dr2I-1je5A:
0.0
4dr2J-1je5A:
0.0		 4dr2I-1je5A:
21.82
4dr2J-1je5A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR5_A_SRYA1860_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 1je5 HELIX-DESTABILIZING
PROTEIN
(Escherichia
virus
T7) 		3 / 3 LYS A 169
PRO A  95
LYS A 109
 None
 1.48A 4dr5L-1je5A:
1.9		 4dr5L-1je5A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR6_A_SRYA1956_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 1je5 HELIX-DESTABILIZING
PROTEIN
(Escherichia
virus
T7) 		3 / 3 LYS A 169
PRO A  95
LYS A 109
 None
 1.42A 4dr6L-1je5A:
1.9		 4dr6L-1je5A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV7_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 1je5 HELIX-DESTABILIZING
PROTEIN
(Escherichia
virus
T7) 		3 / 3 LYS A 169
PRO A  95
LYS A 109
 None
 1.35A 4dv7L-1je5A:
2.0		 4dv7L-1je5A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 1je5 HELIX-DESTABILIZING
PROTEIN
(Escherichia
virus
T7) 		3 / 3 TYR A 153
ARG A  50
SER A   8
 None
 1.18A 4lf7I-1je5A:
0.0
4lf7J-1je5A:
0.0		 4lf7I-1je5A:
21.82
4lf7J-1je5A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 1je5 HELIX-DESTABILIZING
PROTEIN
(Escherichia
virus
T7) 		3 / 3 TYR A 153
ARG A  50
SER A   8
 None
 1.18A 4lf8I-1je5A:
0.0
4lf8J-1je5A:
0.0		 4lf8I-1je5A:
21.82
4lf8J-1je5A:
20.10