SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jeo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1jeo HYPOTHETICAL PROTEIN
MJ1247
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A  40
LEU A  85
VAL A 157
ILE A 158
LEU A 165
 None
 1.03A 1fm6U-1jeoA:
undetectable		 1fm6U-1jeoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1jeo HYPOTHETICAL PROTEIN
MJ1247
(Methanocaldococc
us
jannaschii) 		4 / 8 SER A  11
ASN A  13
ILE A  14
GLU A   6
 None
 0.96A 1meiA-1jeoA:
undetectable		 1meiA-1jeoA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1jeo HYPOTHETICAL PROTEIN
MJ1247
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  16
ILE A  87
ILE A 115
VAL A 134
ILE A  89
 None
None
None
CME  A 117 ( 4.7A)
None
 0.98A 1oipA-1jeoA:
undetectable		 1oipA-1jeoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 1jeo HYPOTHETICAL PROTEIN
MJ1247
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  16
ILE A  87
ILE A 115
VAL A 134
ILE A  89
 None
None
None
CME  A 117 ( 4.7A)
None
 0.96A 1r5lA-1jeoA:
0.1		 1r5lA-1jeoA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 1jeo HYPOTHETICAL PROTEIN
MJ1247
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A  43
PHE A  58
LEU A  62
ARG A  36
 None
 0.95A 2vdbA-1jeoA:
0.0		 2vdbA-1jeoA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 1jeo HYPOTHETICAL PROTEIN
MJ1247
(Methanocaldococc
us
jannaschii) 		4 / 6 THR A  77
GLU A  74
PHE A  46
ILE A  45
 None
 1.30A 2w98B-1jeoA:
undetectable		 2w98B-1jeoA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1jeo HYPOTHETICAL PROTEIN
MJ1247
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  37
ALA A  40
LEU A  85
VAL A 157
LEU A 165
 None
 1.11A 3dzyA-1jeoA:
undetectable		 3dzyA-1jeoA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 1jeo HYPOTHETICAL PROTEIN
MJ1247
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A  77
LYS A 178
GLU A  74
 None
CME  A 177 ( 3.5A)
None
 0.96A 3ijdB-1jeoA:
undetectable		 3ijdB-1jeoA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1jeo HYPOTHETICAL PROTEIN
MJ1247
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  37
ALA A  40
LEU A  85
ILE A 158
LEU A 165
 None
 0.90A 3oapA-1jeoA:
undetectable		 3oapA-1jeoA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1jeo HYPOTHETICAL PROTEIN
MJ1247
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  37
ALA A  40
LEU A  85
VAL A 157
ILE A 158
 None
 0.97A 3oapA-1jeoA:
undetectable		 3oapA-1jeoA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1jeo HYPOTHETICAL PROTEIN
MJ1247
(Methanocaldococc
us
jannaschii) 		3 / 3 GLY A  91
GLY A  93
THR A  95
 CIT  A3000 (-3.6A)
None
CIT  A3000 (-3.5A)
 0.38A 3si7B-1jeoA:
undetectable		 3si7B-1jeoA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 1jeo HYPOTHETICAL PROTEIN
MJ1247
(Methanocaldococc
us
jannaschii) 		5 / 9 LEU A  62
ALA A  59
PHE A  58
VAL A 157
ILE A 161
 None
 1.21A 5om2A-1jeoA:
undetectable
5om2B-1jeoA:
undetectable		 5om2A-1jeoA:
19.55
5om2B-1jeoA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1jeo HYPOTHETICAL PROTEIN
MJ1247
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  37
ALA A  40
LEU A  85
ILE A 158
LEU A 165
 None
 0.76A 6a5yD-1jeoA:
undetectable		 6a5yD-1jeoA:
17.96