SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jeq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_B_117B1_1
(HMG-COA REDUCTASE)		 1jeq KU70
(Homo
sapiens) 		5 / 11 SER A 222
ARG A 194
LEU A 200
ALA A 190
LEU A 147
 None
 1.48A 1hwkA-1jeqA:
0.0		 1hwkA-1jeqA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1jeq KU70
(Homo
sapiens) 		4 / 5 LEU A 261
PRO A 370
VAL A 271
ILE A 269
 None
 0.98A 2aoiB-1jeqA:
undetectable		 2aoiB-1jeqA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1jeq KU70
(Homo
sapiens) 		4 / 6 LEU A 434
GLN A 433
PHE A 432
LEU A 345
 None
 1.12A 2einP-1jeqA:
0.8
2einW-1jeqA:
0.0		 2einP-1jeqA:
18.07
2einW-1jeqA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1jeq KU70
(Homo
sapiens) 		3 / 3 LEU A 259
LEU A 347
MET A 348
 None
 0.71A 2itzA-1jeqA:
2.5		 2itzA-1jeqA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1jeq KU70
(Homo
sapiens) 		5 / 12 ASP A 195
LEU A 193
GLY A 191
ILE A 220
ASP A 219
 None
 0.78A 2nxeA-1jeqA:
2.2		 2nxeA-1jeqA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1jeq KU70
(Homo
sapiens) 		5 / 12 LEU A 168
LEU A 200
VAL A  86
PHE A 216
HIS A 176
 None
 1.29A 2qo6A-1jeqA:
0.4		 2qo6A-1jeqA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 1jeq KU70
(Homo
sapiens) 		4 / 8 ALA A  47
SER A 139
GLY A 136
ALA A  44
 None
 0.93A 2vh3B-1jeqA:
0.5		 2vh3B-1jeqA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 1jeq KU70
(Homo
sapiens) 		5 / 10 VAL A 522
ILE A 465
LEU A 469
ARG A 517
ALA A 513
 None
 1.23A 2xf3A-1jeqA:
0.3		 2xf3A-1jeqA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1jeq KU70
(Homo
sapiens) 		5 / 12 LEU A 437
LEU A 353
PHE A 350
LEU A 347
LEU A 345
 None
 1.30A 3adsA-1jeqA:
0.0		 3adsA-1jeqA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1jeq KU70
(Homo
sapiens) 		3 / 3 PRO A 343
LEU A 259
ARG A 258
 None
 0.92A 3aqiA-1jeqA:
4.5		 3aqiA-1jeqA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1jeq KU70
(Homo
sapiens) 		5 / 12 ASP A 195
LEU A 193
GLY A 191
ILE A 220
ASP A 219
 None
 0.85A 3cjtC-1jeqA:
2.2		 3cjtC-1jeqA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1jeq KU70
(Homo
sapiens) 		5 / 8 VAL A 271
LEU A 261
ILE A 273
VAL A 368
LEU A 413
 None
 1.28A 3kp6A-1jeqA:
undetectable
3kp6B-1jeqA:
undetectable		 3kp6A-1jeqA:
13.80
3kp6B-1jeqA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 1jeq KU70
(Homo
sapiens) 		4 / 8 SER A 236
PHE A  40
LEU A 202
ASP A 201
 None
 0.93A 3m0wE-1jeqA:
undetectable
3m0wF-1jeqA:
undetectable
3m0wG-1jeqA:
undetectable
3m0wH-1jeqA:
undetectable		 3m0wE-1jeqA:
10.67
3m0wF-1jeqA:
10.67
3m0wG-1jeqA:
10.67
3m0wH-1jeqA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 1jeq KU70
(Homo
sapiens) 		3 / 3 ASN A 171
LEU A 143
PHE A 169
 None
 0.81A 4dajB-1jeqA:
undetectable		 4dajB-1jeqA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1jeq KU70
(Homo
sapiens) 		4 / 7 VAL A 268
ILE A 269
LEU A 434
LEU A 413
 None
 0.90A 4l1wA-1jeqA:
undetectable		 4l1wA-1jeqA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 1jeq KU70
(Homo
sapiens) 		4 / 8 LEU A 420
ASP A 421
ASP A 422
LYS A 245
 None
 1.06A 4umjA-1jeqA:
undetectable		 4umjA-1jeqA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 1jeq KU70
(Homo
sapiens) 		4 / 8 SER A  37
LEU A  82
ASP A  81
ASP A  79
 None
 0.78A 4umjA-1jeqA:
undetectable		 4umjA-1jeqA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1jeq KU70
(Homo
sapiens) 		4 / 7 VAL A 268
ILE A 269
LEU A 434
LEU A 413
 None
 0.85A 4xo7A-1jeqA:
undetectable		 4xo7A-1jeqA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1jeq KU70
(Homo
sapiens) 		5 / 12 SER A 257
LEU A 434
LEU A 345
LEU A 259
TYR A 400
 None
 1.28A 4xumA-1jeqA:
undetectable		 4xumA-1jeqA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 1jeq KU70
(Homo
sapiens) 		3 / 3 ARG A 244
LYS A 238
GLU A 240
 None
 0.76A 5d0yA-1jeqA:
0.1		 5d0yA-1jeqA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 1jeq KU70
(Homo
sapiens) 		3 / 3 PRO A 370
LEU A 413
SER A 383
 None
 0.72A 5fsaB-1jeqA:
0.0		 5fsaB-1jeqA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 1jeq KU70
(Homo
sapiens) 		4 / 7 SER A 257
ILE A 273
LEU A 256
PRO A 402
 None
 0.89A 5u4sA-1jeqA:
2.8		 5u4sA-1jeqA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 1jeq KU70
(Homo
sapiens) 		4 / 8 SER A 257
ILE A 273
LEU A 256
PRO A 402
 None
 0.90A 5u4sB-1jeqA:
3.8		 5u4sB-1jeqA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 1jeq KU70
(Homo
sapiens) 		4 / 6 VAL A  97
ASN A  95
ASN A 101
ILE A 102
 None
 1.14A 6h7uA-1jeqA:
undetectable		 6h7uA-1jeqA:
21.67