SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jf5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		5 / 12 HIS A 202
TYR A 204
ASP A 325
HIS A 420
ASP A 421
 None
 0.73A 1dedA-1jf5A:
34.0		 1dedA-1jf5A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		4 / 8 MET A 444
PRO A 450
GLU A 457
ASP A 456
 None
 1.22A 1dtlA-1jf5A:
undetectable		 1dtlA-1jf5A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		3 / 3 GLU A 184
TYR A 181
PHE A 484
 None
 0.97A 1eqbB-1jf5A:
undetectable		 1eqbB-1jf5A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		3 / 3 GLU A 184
TYR A 181
PHE A 484
 None
 0.96A 1eqbA-1jf5A:
undetectable		 1eqbA-1jf5A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		3 / 3 GLU A 184
TYR A 181
PHE A 484
 None
 0.96A 1eqbD-1jf5A:
undetectable		 1eqbD-1jf5A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		3 / 3 GLU A 184
TYR A 181
PHE A 484
 None
 0.97A 1eqbC-1jf5A:
undetectable		 1eqbC-1jf5A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		4 / 7 GLY A  12
ASP A 358
SER A  13
ALA A 359
 None
 0.95A 1gxsA-1jf5A:
undetectable
1gxsB-1jf5A:
0.0		 1gxsA-1jf5A:
17.09
1gxsB-1jf5A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		4 / 6 LEU A 345
ALA A 349
LEU A 341
TRP A 322
 None
 0.95A 1ukbA-1jf5A:
undetectable		 1ukbA-1jf5A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		5 / 11 TYR A 134
GLY A 455
GLY A 459
ILE A 136
PHE A 141
 None
 1.50A 2dr2A-1jf5A:
undetectable		 2dr2A-1jf5A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		3 / 3 LEU A 182
LEU A 451
PHE A 141
 None
 0.73A 2pgrA-1jf5A:
3.8		 2pgrA-1jf5A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		4 / 7 VAL A 440
TYR A 487
ILE A 452
ASP A 418
 None
 1.21A 2x45B-1jf5A:
0.0		 2x45B-1jf5A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		4 / 7 VAL A 440
TYR A 487
ILE A 452
ASP A 418
 None
 1.23A 2x45C-1jf5A:
0.0		 2x45C-1jf5A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF6_0
(GRAMICIDIN A)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		4 / 5 TRP A 414
TRP A 127
ALA A 128
VAL A 132
 None
 1.49A 2xdcE-1jf5A:
undetectable
2xdcF-1jf5A:
undetectable		 2xdcE-1jf5A:
3.02
2xdcF-1jf5A:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_D_DVAD6_0
(VAL-GRAMICIDIN A)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		4 / 5 TRP A 414
TRP A 127
ALA A 128
VAL A 132
 None
 1.49A 2y5mC-1jf5A:
undetectable
2y5mD-1jf5A:
undetectable		 2y5mC-1jf5A:
3.02
2y5mD-1jf5A:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF6_0
(VAL-GRAMICIDIN A)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		4 / 5 TRP A 414
TRP A 127
ALA A 128
VAL A 132
 None
 1.50A 2y5mE-1jf5A:
undetectable
2y5mF-1jf5A:
undetectable		 2y5mE-1jf5A:
3.02
2y5mF-1jf5A:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		4 / 7 VAL A 440
TYR A 487
ILE A 452
ASP A 418
 None
 1.25A 3bu1A-1jf5A:
undetectable		 3bu1A-1jf5A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		5 / 12 VAL A  25
ALA A  10
PHE A  84
ILE A   6
LEU A  86
 None
 1.09A 3hj3D-1jf5A:
undetectable		 3hj3D-1jf5A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		5 / 10 GLY A 503
ILE A 580
PHE A 384
PHE A 519
PHE A 442
 None
 1.50A 3ko0R-1jf5A:
undetectable
3ko0T-1jf5A:
undetectable		 3ko0R-1jf5A:
11.62
3ko0T-1jf5A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		5 / 12 LEU A 426
TYR A 576
ALA A 439
ASP A 456
LEU A 417
 None
 1.15A 3ou6D-1jf5A:
undetectable		 3ou6D-1jf5A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		5 / 12 LEU A 426
TYR A 576
ALA A 439
ASP A 456
LEU A 417
 None
 1.15A 3ou7A-1jf5A:
undetectable		 3ou7A-1jf5A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		5 / 12 LEU A 426
TYR A 576
ALA A 439
ASP A 456
LEU A 417
 None
 1.17A 3ou7D-1jf5A:
undetectable		 3ou7D-1jf5A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		4 / 5 PHE A 192
PHE A 141
ALA A 142
LEU A 225
 None
 1.18A 3t3zC-1jf5A:
undetectable		 3t3zC-1jf5A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		5 / 9 ALA A  93
GLY A  88
LEU A   3
LEU A  86
ILE A   6
 None
 1.09A 3wdmC-1jf5A:
undetectable		 3wdmC-1jf5A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		5 / 8 VAL A 175
LEU A 182
LEU A 179
ASP A 320
ILE A 236
 None
 1.45A 4lzrA-1jf5A:
undetectable		 4lzrA-1jf5A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		4 / 5 ILE A 195
HIS A 244
TYR A 306
VAL A 310
 None
 0.98A 4s0vA-1jf5A:
undetectable		 4s0vA-1jf5A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		4 / 5 ILE A 212
HIS A 244
TYR A 306
VAL A 310
 None
 1.20A 4s0vA-1jf5A:
undetectable		 4s0vA-1jf5A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		4 / 8 MET A 372
SER A 370
ALA A 131
GLY A 448
 None
 0.86A 4xk8a-1jf5A:
undetectable		 4xk8a-1jf5A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		3 / 3 LEU A 296
VAL A 326
ASP A 325
 None
 0.38A 4y8wC-1jf5A:
undetectable		 4y8wC-1jf5A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		5 / 9 MET A 372
SER A 370
TRP A 414
ALA A 131
GLY A 448
 None
 1.17A 5l8rA-1jf5A:
undetectable		 5l8rA-1jf5A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O87_A_NCTA601_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		5 / 10 TYR A 181
TYR A 134
VAL A 440
MET A 444
ILE A 491
 None
 1.35A 5o87A-1jf5A:
0.0
5o87B-1jf5A:
0.0		 5o87A-1jf5A:
10.13
5o87B-1jf5A:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		4 / 5 TRP A 553
LEU A 581
VAL A 562
LEU A 571
 None
 1.09A 5xooB-1jf5A:
0.0		 5xooB-1jf5A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		4 / 6 TRP A 156
LEU A 172
TYR A 454
GLN A 479
 None
 1.29A 6djzC-1jf5A:
2.3		 6djzC-1jf5A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 1jf5 ALPHA AMYLASE II
(Thermoactinomyce
s
vulgaris) 		4 / 5 ILE A 580
THR A 445
THR A 558
LEU A 573
 None
 1.06A 6f3mD-1jf5A:
2.2		 6f3mD-1jf5A:
22.34