SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jfd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MSK_A_SAMA1301_0
(COBALAMIN-DEPENDENT
METHIONINE SYNTHASE)		 1jfd INORGANIC
PYROPHOSPHATASE
(Escherichia
coli) 		5 / 10 ASP A  67
PRO A  22
TYR A  51
PRO A  52
ALA A  23
 None
 1.44A 1mskA-1jfdA:
0.0		 1mskA-1jfdA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 1jfd INORGANIC
PYROPHOSPHATASE
(Escherichia
coli) 		5 / 12 THR A  75
ILE A  15
GLY A  56
ILE A  85
VAL A  69
 None
 1.04A 1nv8B-1jfdA:
undetectable		 1nv8B-1jfdA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 1jfd INORGANIC
PYROPHOSPHATASE
(Escherichia
coli) 		5 / 12 THR A  75
ILE A  15
GLY A  56
ILE A  85
VAL A  69
 None
 1.04A 1sg9B-1jfdA:
undetectable		 1sg9B-1jfdA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1jfd INORGANIC
PYROPHOSPHATASE
(Escherichia
coli) 		5 / 8 ALA A 107
ILE A  15
ILE A  58
GLY A  56
ILE A  19
 None
 1.16A 1sh9A-1jfdA:
undetectable		 1sh9A-1jfdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 1jfd INORGANIC
PYROPHOSPHATASE
(Escherichia
coli) 		5 / 9 GLY A  82
ILE A  28
PHE A  50
PHE A 137
GLY A  56
 None
 1.11A 3ko0A-1jfdA:
undetectable
3ko0C-1jfdA:
undetectable		 3ko0A-1jfdA:
20.67
3ko0C-1jfdA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI201_1
(PROTEIN S100-A4)		 1jfd INORGANIC
PYROPHOSPHATASE
(Escherichia
coli) 		5 / 9 GLY A  56
GLY A  82
ILE A  28
PHE A  50
PHE A 137
 None
 1.09A 3ko0H-1jfdA:
undetectable
3ko0I-1jfdA:
undetectable		 3ko0H-1jfdA:
20.67
3ko0I-1jfdA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 1jfd INORGANIC
PYROPHOSPHATASE
(Escherichia
coli) 		5 / 10 GLY A  82
ILE A  28
PHE A  50
PHE A 137
GLY A  56
 None
 1.15A 3ko0R-1jfdA:
undetectable
3ko0T-1jfdA:
undetectable		 3ko0R-1jfdA:
20.67
3ko0T-1jfdA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 1jfd INORGANIC
PYROPHOSPHATASE
(Escherichia
coli) 		3 / 3 LYS A 142
ARG A  43
ASP A  65
 SO4  A 176 (-2.5A)
SO4  A 176 (-2.8A)
None
 1.41A 3o7wA-1jfdA:
undetectable		 3o7wA-1jfdA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1jfd INORGANIC
PYROPHOSPHATASE
(Escherichia
coli) 		4 / 7 ASP A  42
ASP A 102
GLU A 145
GLU A  31
 None
 1.22A 4fevF-1jfdA:
undetectable		 4fevF-1jfdA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1jfd INORGANIC
PYROPHOSPHATASE
(Escherichia
coli) 		4 / 8 ASP A  42
ASP A 102
GLU A 145
GLU A  31
 None
 1.21A 4gkhB-1jfdA:
0.0		 4gkhB-1jfdA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_B_1FLB201_1
(TRANSTHYRETIN)		 1jfd INORGANIC
PYROPHOSPHATASE
(Escherichia
coli) 		4 / 4 LYS A 173
ALA A 172
SER A  63
THR A  61
 None
 1.39A 4i89B-1jfdA:
0.0		 4i89B-1jfdA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1jfd INORGANIC
PYROPHOSPHATASE
(Escherichia
coli) 		3 / 3 ARG A  88
ASP A  14
ARG A  86
 None
 0.61A 4wq4B-1jfdA:
0.0		 4wq4B-1jfdA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1jfd INORGANIC
PYROPHOSPHATASE
(Escherichia
coli) 		3 / 3 TYR A 141
ARG A  43
LYS A 142
 SO4  A 176 (-4.3A)
SO4  A 176 (-2.8A)
SO4  A 176 (-2.5A)
 1.24A 4wq5B-1jfdA:
0.0		 4wq5B-1jfdA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 1jfd INORGANIC
PYROPHOSPHATASE
(Escherichia
coli) 		4 / 8 GLY A  56
GLU A  20
ASP A  42
ARG A  43
 None
None
None
SO4  A 176 (-2.8A)
 0.94A 5gqbA-1jfdA:
undetectable		 5gqbA-1jfdA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1jfd INORGANIC
PYROPHOSPHATASE
(Escherichia
coli) 		4 / 8 LEU A 105
VAL A  71
VAL A  69
ILE A  15
 None
 0.79A 5y9mA-1jfdA:
undetectable		 5y9mA-1jfdA:
13.64