SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jfl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1jfl ASPARTATE RACEMASE
(Pyrococcus
horikoshii) 		5 / 8 ALA A  75
ASP A  76
ILE A  78
ILE A  22
PRO A  81
 None
 1.25A 1sh9A-1jflA:
undetectable		 1sh9A-1jflA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 1jfl ASPARTATE RACEMASE
(Pyrococcus
horikoshii) 		3 / 3 LYS A 164
GLY A   9
PRO A  43
 None
 1.00A 2hreB-1jflA:
1.7		 2hreB-1jflA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 1jfl ASPARTATE RACEMASE
(Pyrococcus
horikoshii) 		3 / 3 ARG A 172
VAL A 155
THR A 178
 None
 0.80A 2nmzA-1jflA:
undetectable		 2nmzA-1jflA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)		 1jfl ASPARTATE RACEMASE
(Pyrococcus
horikoshii) 		6 / 12 ALA A  67
ILE A  98
GLY A   5
ILE A   6
VAL A  89
ILE A  92
 None
 1.31A 3d1xA-1jflA:
undetectable		 3d1xA-1jflA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 1jfl ASPARTATE RACEMASE
(Pyrococcus
horikoshii) 		3 / 3 ARG A 172
VAL A 155
THR A 178
 None
 0.83A 3pwrA-1jflA:
undetectable		 3pwrA-1jflA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 1jfl ASPARTATE RACEMASE
(Pyrococcus
horikoshii) 		6 / 12 ALA A  67
ILE A  98
GLY A   5
ILE A   6
VAL A  89
ILE A  92
 None
 1.42A 3tl9A-1jflA:
undetectable		 3tl9A-1jflA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)		 1jfl ASPARTATE RACEMASE
(Pyrococcus
horikoshii) 		5 / 11 ALA A  67
ILE A  98
GLY A   5
ILE A   6
ILE A  92
 None
 0.94A 4njtC-1jflA:
undetectable		 4njtC-1jflA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 1jfl ASPARTATE RACEMASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 181
THR A 178
THR A 148
LEU A 182
LEU A 122
 None
 1.30A 4pbhA-1jflA:
1.0		 4pbhA-1jflA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1jfl ASPARTATE RACEMASE
(Pyrococcus
horikoshii) 		4 / 8 ALA A 179
ASN A  83
GLY A 193
VAL A 163
 None
 0.85A 4r20A-1jflA:
undetectable		 4r20A-1jflA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1jfl ASPARTATE RACEMASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A 181
VAL A 197
LEU A 175
ILE A 159
 None
 0.86A 4r38D-1jflA:
undetectable		 4r38D-1jflA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1jfl ASPARTATE RACEMASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 206
LEU A 210
ILE A 190
LEU A 182
VAL A 197
 None
 0.95A 4y0rA-1jflA:
undetectable		 4y0rA-1jflA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 1jfl ASPARTATE RACEMASE
(Pyrococcus
horikoshii) 		6 / 12 ALA A  67
ILE A  98
GLY A   5
ILE A   6
VAL A  89
ILE A  92
 None
 1.34A 5kqxA-1jflA:
undetectable		 5kqxA-1jflA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 1jfl ASPARTATE RACEMASE
(Pyrococcus
horikoshii) 		5 / 10 ALA A  85
ILE A  45
GLY A   8
ILE A   6
ILE A  92
 None
 0.75A 5kr1A-1jflA:
undetectable		 5kr1A-1jflA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1jfl ASPARTATE RACEMASE
(Pyrococcus
horikoshii) 		3 / 3 GLY A 193
THR A 124
ASN A  83
 None
 0.62A 5odiG-1jflA:
5.8		 5odiG-1jflA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_A_NCTA405_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4)		 1jfl ASPARTATE RACEMASE
(Pyrococcus
horikoshii) 		4 / 6 TYR A 160
THR A  49
CYH A  82
THR A 127
 None
 1.28A 6cnkA-1jflA:
undetectable
6cnkB-1jflA:
undetectable		 6cnkA-1jflA:
25.42
6cnkB-1jflA:
25.42