SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jfr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 1jfr LIPASE
(Streptomyces
exfoliatus) 		5 / 10 GLY A  62
PHE A  63
SER A 131
MET A 132
HIS A 209
 None
 0.75A 1a8uA-1jfrA:
16.0		 1a8uA-1jfrA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 1jfr LIPASE
(Streptomyces
exfoliatus) 		5 / 10 GLY A  62
PHE A  63
SER A 131
MET A 132
HIS A 209
 None
 0.74A 1a8uB-1jfrA:
16.0		 1a8uB-1jfrA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 1jfr LIPASE
(Streptomyces
exfoliatus) 		4 / 6 ILE A 231
ARG A 124
TYR A 237
VAL A  84
 None
 1.01A 1db1A-1jfrA:
undetectable		 1db1A-1jfrA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 1jfr LIPASE
(Streptomyces
exfoliatus) 		4 / 6 TRP A 162
GLY A 133
ASN A 157
PRO A  61
 None
 1.48A 1dedA-1jfrA:
undetectable		 1dedA-1jfrA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 1jfr LIPASE
(Streptomyces
exfoliatus) 		5 / 11 GLY A 173
ASN A 213
THR A 154
GLY A 155
HIS A 130
 None
 1.40A 2hmaA-1jfrA:
undetectable		 2hmaA-1jfrA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 1jfr LIPASE
(Streptomyces
exfoliatus) 		5 / 12 ILE A  87
ASP A  88
VAL A  58
ILE A  59
ILE A  70
 None
 1.26A 2yzqA-1jfrA:
undetectable		 2yzqA-1jfrA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1jfr LIPASE
(Streptomyces
exfoliatus) 		4 / 6 VAL A  57
SER A 223
LEU A 197
ALA A 149
 None
 0.88A 3kk6B-1jfrA:
undetectable		 3kk6B-1jfrA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 1jfr LIPASE
(Streptomyces
exfoliatus) 		5 / 9 PRO A 152
THR A 169
LEU A 165
LEU A 193
SER A 192
 None
 1.50A 3q1eB-1jfrA:
0.0
3q1eD-1jfrA:
0.0		 3q1eB-1jfrA:
19.62
3q1eD-1jfrA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 1jfr LIPASE
(Streptomyces
exfoliatus) 		4 / 6 ALA A 140
ALA A 150
LEU A 147
THR A 167
 None
 1.04A 4dtzB-1jfrA:
0.0		 4dtzB-1jfrA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 1jfr LIPASE
(Streptomyces
exfoliatus) 		4 / 4 ILE A  43
VAL A  57
VAL A  83
ARG A 119
 None
 1.17A 4m6tA-1jfrA:
0.0		 4m6tA-1jfrA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1jfr LIPASE
(Streptomyces
exfoliatus) 		5 / 12 SER A 225
LEU A  77
VAL A  84
MET A 128
LEU A 241
 None
 1.41A 4o8fB-1jfrA:
0.0		 4o8fB-1jfrA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jfr LIPASE
(Streptomyces
exfoliatus) 		4 / 7 LEU A 165
TRP A 162
ALA A 140
SER A 143
 None
 0.87A 5f1aB-1jfrA:
0.0		 5f1aB-1jfrA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1jfr LIPASE
(Streptomyces
exfoliatus) 		5 / 12 GLY A 133
LEU A 138
GLY A 135
GLY A 134
PRO A 152
 None
 0.98A 5wyqB-1jfrA:
2.2		 5wyqB-1jfrA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 1jfr LIPASE
(Streptomyces
exfoliatus) 		4 / 8 LEU A 165
GLU A 139
THR A 169
ASN A 157
 None
 1.15A 6c71B-1jfrA:
undetectable		 6c71B-1jfrA:
17.94