SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jft'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 8 GLY A 246
GLY A 199
PHE A 200
GLY A 195
 None
 0.57A 1d0vA-1jftA:
undetectable		 1d0vA-1jftA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 8 ALA A  66
GLY A  63
ILE A  93
ILE A  78
 None
 0.64A 1d4yB-1jftA:
undetectable		 1d4yB-1jftA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 8 GLY A 246
GLY A 199
PHE A 200
GLY A 195
 None
 0.56A 1jhaA-1jftA:
undetectable		 1jhaA-1jftA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 9 GLY A 246
GLY A 199
PHE A 200
LEU A 197
GLY A 195
 None
 1.01A 1jhoA-1jftA:
undetectable		 1jhoA-1jftA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 8 GLY A 246
GLY A 199
PHE A 200
GLY A 195
 None
 0.58A 1jhqA-1jftA:
undetectable		 1jhqA-1jftA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 8 GLY A 246
GLY A 199
PHE A 200
LEU A 197
GLY A 195
 None
 0.97A 1jhvA-1jftA:
undetectable		 1jhvA-1jftA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 9 GLY A 246
GLY A 199
PHE A 200
LEU A 197
GLY A 195
 None
 1.02A 1l5kA-1jftA:
undetectable		 1l5kA-1jftA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 9 GLY A 246
GLY A 199
PHE A 200
LEU A 197
GLY A 195
 None
 1.04A 1l5lA-1jftA:
2.9		 1l5lA-1jftA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 12 LEU A 130
TYR A 126
LEU A 108
LEU A 119
MET A 142
 None
 1.36A 1p33A-1jftA:
7.0		 1p33A-1jftA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_2
(BETA-LACTAMASE
CTX-M-9)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 5 CYH A 245
TYR A  73
PRO A 187
THR A 289
 None
HPA  A 599 (-3.2A)
None
None
 1.21A 1ymxA-1jftA:
undetectable		 1ymxA-1jftA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 5 CYH A 245
TYR A  73
PRO A 187
THR A 289
 None
HPA  A 599 (-3.2A)
None
None
 1.21A 1ymxB-1jftA:
undetectable		 1ymxB-1jftA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 12 GLY A 253
ALA A 254
VAL A 243
ILE A 233
PRO A 185
 None
 0.88A 2f8gB-1jftA:
undetectable		 2f8gB-1jftA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 12 GLY A 165
GLY A 195
LEU A 325
GLU A 164
ILE A 272
 None
 1.02A 2oxtC-1jftA:
2.5		 2oxtC-1jftA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		3 / 3 TRP A 215
VAL A 331
ARG A 328
 None
 0.73A 3b0wA-1jftA:
0.0		 3b0wA-1jftA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 8 LEU A 305
ILE A  62
GLY A  89
LYS A  88
 None
 0.90A 3b9lA-1jftA:
0.0		 3b9lA-1jftA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 12 GLY A  95
ASN A  96
ILE A  62
GLY A 118
LEU A  94
 None
 1.03A 3eeyA-1jftA:
undetectable		 3eeyA-1jftA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 12 GLY A  95
ASN A  96
ILE A  62
GLY A 118
LEU A  94
 None
 1.01A 3eeyB-1jftA:
undetectable		 3eeyB-1jftA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 12 GLY A  95
ASN A  96
GLY A 118
LEU A  94
THR A  59
 None
 1.14A 3eeyC-1jftA:
3.3		 3eeyC-1jftA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 12 GLY A  95
ASN A  96
ILE A  62
GLY A 118
LEU A  94
 None
 1.01A 3eeyC-1jftA:
3.3		 3eeyC-1jftA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 12 GLY A  95
ASN A  96
ILE A  62
GLY A 118
LEU A  94
 None
 1.02A 3eeyD-1jftA:
undetectable		 3eeyD-1jftA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 12 GLY A  95
ASN A  96
ILE A  62
GLY A 118
LEU A  94
 None
 1.06A 3eeyE-1jftA:
undetectable		 3eeyE-1jftA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 12 GLY A  95
ASN A  96
ILE A  62
GLY A 118
LEU A  94
 None
 1.14A 3eeyH-1jftA:
2.1		 3eeyH-1jftA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 12 GLY A  95
ASN A  96
ILE A  62
GLY A 118
LEU A  94
 None
 1.11A 3eeyI-1jftA:
undetectable		 3eeyI-1jftA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 12 GLY A  95
ASN A  96
ILE A  62
GLY A 118
LEU A  94
 None
 1.12A 3eeyJ-1jftA:
2.4		 3eeyJ-1jftA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		3 / 3 MET A 133
CYH A 123
PRO A 127
 None
 1.26A 3h52C-1jftA:
0.0		 3h52C-1jftA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_2
(BETA-LACTAMASE)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 5 CYH A 245
TYR A  73
PRO A 187
THR A 289
 None
HPA  A 599 (-3.2A)
None
None
 1.21A 3q07A-1jftA:
undetectable		 3q07A-1jftA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_2
(BETA-LACTAMASE)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 5 CYH A 245
TYR A  73
PRO A 187
THR A 289
 None
HPA  A 599 (-3.2A)
None
None
 1.20A 3q07B-1jftA:
undetectable		 3q07B-1jftA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 12 PHE A 244
GLY A 166
GLY A 170
ALA A 203
GLY A 199
 None
 1.11A 3tegA-1jftA:
undetectable		 3tegA-1jftA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 8 GLY A 170
LEU A 173
ILE A 174
ILE A 209
 None
 0.72A 4em2A-1jftA:
undetectable		 4em2A-1jftA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 12 VAL A 277
ILE A 184
GLY A 253
GLY A 226
ILE A 249
 None
 1.03A 4iv0A-1jftA:
3.1		 4iv0A-1jftA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 9 GLY A 246
GLY A 199
PHE A 200
LEU A 197
GLY A 195
 None
 1.01A 4kqiA-1jftA:
undetectable		 4kqiA-1jftA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_1
(ANDROGEN RECEPTOR)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 12 LEU A  64
GLY A  63
LEU A 305
MET A 142
VAL A 144
 None
 1.48A 4ojbA-1jftA:
undetectable		 4ojbA-1jftA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 12 LEU A  64
GLY A  63
LEU A 305
MET A 142
VAL A 144
 None
 1.47A 4okxA-1jftA:
undetectable		 4okxA-1jftA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 12 VAL A 183
GLY A 186
PHE A 244
GLY A 273
ASP A 275
 None
None
None
None
HPA  A 599 (-2.8A)
 1.39A 4pevB-1jftA:
19.0		 4pevB-1jftA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 11 LEU A 134
TYR A 137
GLU A 128
LEU A 130
LEU A 108
 None
 0.95A 4wg0C-1jftA:
undetectable
4wg0D-1jftA:
undetectable
4wg0E-1jftA:
undetectable		 4wg0C-1jftA:
3.90
4wg0D-1jftA:
3.90
4wg0E-1jftA:
3.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 11 LEU A 108
GLU A 128
LEU A 130
LEU A 134
TYR A 137
 None
 0.96A 4wg0F-1jftA:
undetectable
4wg0G-1jftA:
undetectable
4wg0H-1jftA:
undetectable		 4wg0F-1jftA:
3.90
4wg0G-1jftA:
3.90
4wg0H-1jftA:
3.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 11 LEU A 134
TYR A 137
GLU A 128
LEU A 130
LEU A 108
 None
 0.94A 4wg0E-1jftA:
undetectable
4wg0F-1jftA:
undetectable
4wg0G-1jftA:
undetectable		 4wg0E-1jftA:
3.90
4wg0F-1jftA:
3.90
4wg0G-1jftA:
3.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 11 LEU A 134
TYR A 137
GLU A 128
LEU A 130
LEU A 108
 None
 1.04A 4wg0K-1jftA:
undetectable
4wg0L-1jftA:
undetectable
4wg0M-1jftA:
undetectable		 4wg0K-1jftA:
3.90
4wg0L-1jftA:
3.90
4wg0M-1jftA:
3.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 11 PHE A 244
ASP A 248
TYR A  73
GLY A 166
GLY A 273
 None
None
HPA  A 599 (-3.2A)
None
None
 1.01A 4xnxA-1jftA:
0.0		 4xnxA-1jftA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 6 ASP A 275
ALA A 251
THR A 289
TYR A 274
 HPA  A 599 (-2.8A)
None
None
None
 1.01A 4z4cA-1jftA:
7.5		 4z4cA-1jftA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 6 ASP A 275
ALA A 251
THR A 289
TYR A 274
 HPA  A 599 (-2.8A)
None
None
None
 1.02A 4z4fA-1jftA:
7.4		 4z4fA-1jftA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 5 ASP A 275
ALA A 251
THR A 289
TYR A 274
 HPA  A 599 (-2.8A)
None
None
None
 1.02A 4z4gA-1jftA:
7.5		 4z4gA-1jftA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 6 ASP A 275
ALA A 251
THR A 289
TYR A 274
 HPA  A 599 (-2.8A)
None
None
None
 0.98A 4z4iA-1jftA:
7.1		 4z4iA-1jftA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 9 MET A 201
PHE A 200
GLY A 195
ARG A 196
GLY A 166
 None
None
None
HPA  A 599 (-3.1A)
None
 1.41A 5l8rA-1jftA:
undetectable		 5l8rA-1jftA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 4 PRO A 266
MET A 230
GLY A 226
VAL A 243
 None
 1.24A 6ak3A-1jftA:
0.0		 6ak3A-1jftA:
13.90