SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jfx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 1jfx 1,4-BETA-N-ACETYLMUR
AMIDASE M1
(Streptomyces
coelicolor) 		4 / 5 GLY A  60
LEU A  93
THR A  92
VAL A  96
 None
 1.09A 1ekjF-1jfxA:
0.8
1ekjG-1jfxA:
0.8		 1ekjF-1jfxA:
21.14
1ekjG-1jfxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1jfx 1,4-BETA-N-ACETYLMUR
AMIDASE M1
(Streptomyces
coelicolor) 		4 / 6 VAL A 136
ILE A  57
ILE A  17
ASP A   9
 None
 0.87A 1uwhB-1jfxA:
undetectable		 1uwhB-1jfxA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1jfx 1,4-BETA-N-ACETYLMUR
AMIDASE M1
(Streptomyces
coelicolor) 		4 / 7 LEU A  97
GLY A 153
VAL A 135
ILE A 137
 None
 0.60A 2aojB-1jfxA:
undetectable		 2aojB-1jfxA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 1jfx 1,4-BETA-N-ACETYLMUR
AMIDASE M1
(Streptomyces
coelicolor) 		3 / 3 ASN A 214
TYR A  53
SER A  87
 None
 0.63A 2gvcB-1jfxA:
0.0		 2gvcB-1jfxA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 1jfx 1,4-BETA-N-ACETYLMUR
AMIDASE M1
(Streptomyces
coelicolor) 		3 / 3 ASN A 214
TYR A  53
SER A  87
 None
 0.61A 2gvcE-1jfxA:
1.5		 2gvcE-1jfxA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1jfx 1,4-BETA-N-ACETYLMUR
AMIDASE M1
(Streptomyces
coelicolor) 		4 / 8 LEU A 209
PRO A 159
VAL A  96
GLY A  95
 None
 0.97A 2po5B-1jfxA:
undetectable		 2po5B-1jfxA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1jfx 1,4-BETA-N-ACETYLMUR
AMIDASE M1
(Streptomyces
coelicolor) 		5 / 9 LEU A 209
ARG A  59
PRO A 159
VAL A  96
GLY A  95
 None
 1.49A 2po7B-1jfxA:
1.2		 2po7B-1jfxA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 1jfx 1,4-BETA-N-ACETYLMUR
AMIDASE M1
(Streptomyces
coelicolor) 		4 / 8 LEU A 209
PRO A 159
VAL A  96
GLY A  95
 None
 0.95A 2qd5A-1jfxA:
undetectable		 2qd5A-1jfxA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 1jfx 1,4-BETA-N-ACETYLMUR
AMIDASE M1
(Streptomyces
coelicolor) 		4 / 8 LEU A 209
PRO A 159
VAL A  96
GLY A  95
 None
 0.88A 2qd5B-1jfxA:
undetectable		 2qd5B-1jfxA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1jfx 1,4-BETA-N-ACETYLMUR
AMIDASE M1
(Streptomyces
coelicolor) 		5 / 9 LEU A 209
ARG A  59
PRO A 159
VAL A  96
GLY A  95
 None
 1.19A 3hcnB-1jfxA:
1.3		 3hcnB-1jfxA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1jfx 1,4-BETA-N-ACETYLMUR
AMIDASE M1
(Streptomyces
coelicolor) 		5 / 10 LEU A 209
ARG A  59
PRO A 159
VAL A  96
GLY A  95
 None
 1.16A 3hcoB-1jfxA:
0.8		 3hcoB-1jfxA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1jfx 1,4-BETA-N-ACETYLMUR
AMIDASE M1
(Streptomyces
coelicolor) 		3 / 3 SER A  71
GLY A  72
THR A  73
 None
 0.12A 3k9wA-1jfxA:
undetectable		 3k9wA-1jfxA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 1jfx 1,4-BETA-N-ACETYLMUR
AMIDASE M1
(Streptomyces
coelicolor) 		5 / 11 GLY A  60
TYR A  31
TRP A 161
TYR A 127
GLY A  85
 None
 1.19A 4ey7A-1jfxA:
undetectable		 4ey7A-1jfxA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 1jfx 1,4-BETA-N-ACETYLMUR
AMIDASE M1
(Streptomyces
coelicolor) 		5 / 11 GLY A  60
TYR A  31
TRP A 161
TYR A 127
GLY A  85
 None
 1.22A 4ey7B-1jfxA:
undetectable		 4ey7B-1jfxA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 1jfx 1,4-BETA-N-ACETYLMUR
AMIDASE M1
(Streptomyces
coelicolor) 		5 / 11 PHE A 123
LEU A  97
GLY A  72
SER A  70
ARG A  66
 None
None
None
CL  A1008 (-3.2A)
None
 1.31A 4zbqA-1jfxA:
undetectable		 4zbqA-1jfxA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 1jfx 1,4-BETA-N-ACETYLMUR
AMIDASE M1
(Streptomyces
coelicolor) 		4 / 8 ALA A  80
ARG A 130
HIS A  63
THR A  35
 None
 1.28A 5db5A-1jfxA:
undetectable
5db5B-1jfxA:
undetectable		 5db5A-1jfxA:
19.75
5db5B-1jfxA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1jfx 1,4-BETA-N-ACETYLMUR
AMIDASE M1
(Streptomyces
coelicolor) 		4 / 5 GLN A 183
VAL A 162
TRP A 182
THR A 171
 None
 1.45A 6cduA-1jfxA:
undetectable
6cduB-1jfxA:
undetectable		 6cduA-1jfxA:
23.55
6cduB-1jfxA:
23.55