SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jg3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
4 / 7 LEU A 108
ALA A  42
PHE A  43
TYR A  49
None
0.83A 1epbA-1jg3A:
undetectable
1epbA-1jg3A:
21.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
12 / 12 GLN A  72
GLY A  99
GLY A 101
GLU A 121
ILE A 123
LEU A 126
ASP A 148
GLY A 149
THR A 165
ALA A 166
VAL A 219
LEU A 221
ADN  A 500 (-3.7A)
ADN  A 500 (-3.2A)
ADN  A 500 (-3.4A)
ADN  A 500 (-2.9A)
ADN  A 500 (-4.6A)
ADN  A 500 (-4.2A)
ADN  A 500 (-3.7A)
ADN  A 500 (-3.3A)
ADN  A 500 (-4.5A)
ADN  A 500 ( 4.0A)
None
ADN  A 500 (-4.2A)
0.35A 1jg2A-1jg3A:
41.6
1jg2A-1jg3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
6 / 12 GLN A  72
THR A  73
VAL A  74
GLY A 101
TRP A 104
GLY A 147
ADN  A 500 (-3.7A)
NA  A 402 ( 3.9A)
None
ADN  A 500 (-3.4A)
None
None
1.06A 1jg4A-1jg3A:
41.2
1jg4A-1jg3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
12 / 12 GLN A  72
THR A  73
VAL A  74
SER A  75
GLY A 101
TRP A 104
ASN A 105
GLY A 149
THR A 165
ALA A 166
VAL A 219
LEU A 221
ADN  A 500 (-3.7A)
NA  A 402 ( 3.9A)
None
NA  A 402 ( 4.2A)
ADN  A 500 (-3.4A)
None
None
ADN  A 500 (-3.3A)
ADN  A 500 (-4.5A)
ADN  A 500 ( 4.0A)
None
ADN  A 500 (-4.2A)
0.44A 1jg4A-1jg3A:
41.2
1jg4A-1jg3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
8 / 8 GLU A  97
GLY A  99
SER A 102
GLU A 121
ARG A 122
ILE A 123
LEU A 126
ASP A 148
None
ADN  A 500 (-3.2A)
None
ADN  A 500 (-2.9A)
None
ADN  A 500 (-4.6A)
ADN  A 500 (-4.2A)
ADN  A 500 (-3.7A)
0.15A 1jg4A-1jg3A:
41.2
1jg4A-1jg3A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
5 / 12 GLU A  97
GLY A  99
GLY A 101
LEU A 126
ASP A 148
None
ADN  A 500 (-3.2A)
ADN  A 500 (-3.4A)
ADN  A 500 (-4.2A)
ADN  A 500 (-3.7A)
0.47A 1qaoA-1jg3A:
8.9
1qaoA-1jg3A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
5 / 12 ALA A  87
ILE A  86
VAL A  39
PHE A  43
LEU A  28
None
1.09A 1uduB-1jg3A:
undetectable
1uduB-1jg3A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
5 / 11 ALA A  87
ILE A  86
VAL A  39
PHE A  43
LEU A  28
None
1.21A 2h42A-1jg3A:
0.0
2h42A-1jg3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
6 / 11 GLU A  97
GLY A  99
GLY A 101
ILE A 120
GLU A 121
ASP A 148
None
ADN  A 500 (-3.2A)
ADN  A 500 (-3.4A)
ADN  A 500 (-4.6A)
ADN  A 500 (-2.9A)
ADN  A 500 (-3.7A)
0.58A 3dxyA-1jg3A:
7.8
3dxyA-1jg3A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
6 / 12 GLN A  72
VAL A  98
GLY A  99
GLY A 101
GLU A 121
ASP A 148
ADN  A 500 (-3.7A)
None
ADN  A 500 (-3.2A)
ADN  A 500 (-3.4A)
ADN  A 500 (-2.9A)
ADN  A 500 (-3.7A)
0.91A 3fuuA-1jg3A:
9.4
3fuuA-1jg3A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
5 / 11 GLY A  99
GLY A 101
GLU A 121
LEU A 126
ASP A 148
ADN  A 500 (-3.2A)
ADN  A 500 (-3.4A)
ADN  A 500 (-2.9A)
ADN  A 500 (-4.2A)
ADN  A 500 (-3.7A)
0.75A 3grvA-1jg3A:
10.7
3grvA-1jg3A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
6 / 12 GLU A  97
GLY A  99
GLY A 101
GLU A 121
LEU A 126
ASP A 148
None
ADN  A 500 (-3.2A)
ADN  A 500 (-3.4A)
ADN  A 500 (-2.9A)
ADN  A 500 (-4.2A)
ADN  A 500 (-3.7A)
0.83A 3gryA-1jg3A:
10.3
3gryA-1jg3A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
4 / 4 LEU A 175
ALA A 168
VAL A 189
PRO A 188
None
1.15A 3gv1B-1jg3A:
undetectable
3gv1B-1jg3A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
5 / 9 ILE A  86
PHE A 218
LEU A  96
GLU A  97
GLY A 167
None
1.24A 3nxuB-1jg3A:
0.0
3nxuB-1jg3A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
5 / 12 GLU A  97
GLY A  99
GLY A 101
ASN A 105
ASP A 148
None
ADN  A 500 (-3.2A)
ADN  A 500 (-3.4A)
None
ADN  A 500 (-3.7A)
0.82A 3sglA-1jg3A:
6.4
3sglA-1jg3A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
5 / 12 SER A 102
LEU A  84
VAL A  39
PHE A  43
VAL A  80
None
1.34A 3u9fB-1jg3A:
0.0
3u9fC-1jg3A:
0.0
3u9fB-1jg3A:
20.80
3u9fC-1jg3A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
5 / 10 SER A 102
LEU A  84
VAL A  39
PHE A  43
VAL A  80
None
1.47A 3u9fI-1jg3A:
0.0
3u9fI-1jg3A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
5 / 12 SER A 102
LEU A  84
VAL A  39
PHE A  43
VAL A  80
None
1.41A 3u9fJ-1jg3A:
0.0
3u9fK-1jg3A:
0.0
3u9fJ-1jg3A:
20.80
3u9fK-1jg3A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
5 / 10 SER A 102
LEU A  84
VAL A  39
PHE A  43
VAL A  80
None
1.45A 3u9fK-1jg3A:
0.0
3u9fK-1jg3A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
5 / 11 SER A 102
LEU A  84
VAL A  39
PHE A  43
VAL A  80
None
1.43A 3u9fN-1jg3A:
0.0
3u9fO-1jg3A:
0.0
3u9fN-1jg3A:
20.80
3u9fO-1jg3A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
5 / 9 SER A 102
LEU A  84
VAL A  39
PHE A  43
VAL A  80
None
1.43A 3u9fP-1jg3A:
0.5
3u9fP-1jg3A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
5 / 10 SER A 102
LEU A  84
VAL A  39
PHE A  43
VAL A  80
None
1.37A 3u9fR-1jg3A:
0.5
3u9fR-1jg3A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
5 / 12 SER A 102
LEU A  84
VAL A  39
PHE A  43
VAL A  80
None
1.34A 3u9fP-1jg3A:
0.5
3u9fS-1jg3A:
0.0
3u9fP-1jg3A:
20.80
3u9fS-1jg3A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
5 / 12 LEU A 175
ASP A 160
ILE A 145
VAL A 164
ILE A 162
None
None
CL  A 300 ( 4.7A)
None
None
0.91A 4q1xB-1jg3A:
undetectable
4q1xB-1jg3A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
5 / 12 ILE A 162
GLY A 152
ASP A 148
GLY A  99
ILE A 145
None
None
ADN  A 500 (-3.7A)
ADN  A 500 (-3.2A)
CL  A 300 ( 4.7A)
0.91A 4q5mA-1jg3A:
undetectable
4q5mA-1jg3A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
5 / 12 LEU A  89
ASN A  88
VAL A  80
ALA A  81
ILE A 163
None
0.97A 4x20B-1jg3A:
0.0
4x20B-1jg3A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
5 / 7 GLY A  99
GLY A 101
SER A 102
GLU A 121
ASP A 148
ADN  A 500 (-3.2A)
ADN  A 500 (-3.4A)
None
ADN  A 500 (-2.9A)
ADN  A 500 (-3.7A)
0.77A 5ergB-1jg3A:
11.5
5ergB-1jg3A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
5 / 12 ASP A 148
THR A  73
GLY A 101
SER A 102
GLU A 121
ADN  A 500 (-3.7A)
NA  A 402 ( 3.9A)
ADN  A 500 (-3.4A)
None
ADN  A 500 (-2.9A)
1.18A 5hfjF-1jg3A:
undetectable
5hfjF-1jg3A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
5 / 12 GLY A 101
GLY A  99
VAL A 127
LEU A 126
ALA A  70
ADN  A 500 (-3.4A)
ADN  A 500 (-3.2A)
None
ADN  A 500 (-4.2A)
None
0.94A 5kpcA-1jg3A:
9.1
5kpcA-1jg3A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
5 / 10 LEU A 175
ASP A 160
ILE A 145
VAL A 164
ILE A 162
None
None
CL  A 300 ( 4.7A)
None
None
1.06A 5kr1A-1jg3A:
undetectable
5kr1A-1jg3A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
5 / 11 VAL A  98
GLY A  99
GLU A 121
ASP A 148
LEU A 221
None
ADN  A 500 (-3.2A)
ADN  A 500 (-2.9A)
ADN  A 500 (-3.7A)
ADN  A 500 (-4.2A)
1.13A 5x6yA-1jg3A:
5.1
5x6yA-1jg3A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
5 / 10 VAL A  98
GLY A  99
GLU A 121
ASP A 148
LEU A 221
None
ADN  A 500 (-3.2A)
ADN  A 500 (-2.9A)
ADN  A 500 (-3.7A)
ADN  A 500 (-4.2A)
1.11A 5x6yB-1jg3A:
undetectable
5x6yB-1jg3A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
5 / 11 VAL A  98
GLY A  99
GLU A 121
ASP A 148
LEU A 221
None
ADN  A 500 (-3.2A)
ADN  A 500 (-2.9A)
ADN  A 500 (-3.7A)
ADN  A 500 (-4.2A)
1.01A 5x6yC-1jg3A:
4.7
5x6yC-1jg3A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus)
4 / 7 VAL A 201
PRO A 220
LEU A 194
PHE A 218
None
1.05A 6aycA-1jg3A:
undetectable
6aycA-1jg3A:
17.03