SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jg5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 1jg5 GTP CYCLOHYDROLASE I
FEEDBACK REGULATORY
PROTEIN
(Rattus
norvegicus) 		4 / 7 THR A  75
SER A  68
THR A  70
VAL A  72
 None
 0.74A 1ictD-1jg5A:
undetectable		 1ictD-1jg5A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 1jg5 GTP CYCLOHYDROLASE I
FEEDBACK REGULATORY
PROTEIN
(Rattus
norvegicus) 		5 / 12 LEU A  59
PRO A  52
THR A  16
THR A   7
LEU A  80
 None
None
None
K  A1504 (-3.8A)
None
 1.15A 2uvnA-1jg5A:
undetectable		 2uvnA-1jg5A:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_A_T44A128_1
(TRANSTHYRETIN)		 1jg5 GTP CYCLOHYDROLASE I
FEEDBACK REGULATORY
PROTEIN
(Rattus
norvegicus) 		5 / 9 LEU A   4
THR A  75
SER A  68
THR A  70
VAL A  72
 None
 1.07A 3ozkA-1jg5A:
undetectable		 3ozkA-1jg5A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 1jg5 GTP CYCLOHYDROLASE I
FEEDBACK REGULATORY
PROTEIN
(Rattus
norvegicus) 		5 / 8 LEU A   4
THR A  75
SER A  68
THR A  70
VAL A  72
 None
 1.00A 4ik7B-1jg5A:
undetectable		 4ik7B-1jg5A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 1jg5 GTP CYCLOHYDROLASE I
FEEDBACK REGULATORY
PROTEIN
(Rattus
norvegicus) 		4 / 4 LEU A  80
SER A  68
LEU A   4
LEU A  56
 None
 1.05A 4n09A-1jg5A:
undetectable		 4n09A-1jg5A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 1jg5 GTP CYCLOHYDROLASE I
FEEDBACK REGULATORY
PROTEIN
(Rattus
norvegicus) 		4 / 7 LEU A  27
VAL A  55
LEU A  59
LEU A  80
 None
 0.75A 6g9bA-1jg5A:
undetectable
6g9bB-1jg5A:
undetectable		 6g9bA-1jg5A:
27.06
6g9bB-1jg5A:
19.54