SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jgs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1jgs MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR
(Escherichia
coli) 		3 / 3 VAL A  21
LYS A  24
HIS A 120
 None
 0.89A 3elzA-1jgsA:
0.0		 3elzA-1jgsA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1jgs MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR
(Escherichia
coli) 		5 / 9 ALA A  41
LEU A  78
ILE A  49
LEU A 100
THR A  39
 SAL  A 257 (-3.2A)
None
None
None
SAL  A 257 (-3.5A)
 1.34A 3fl9H-1jgsA:
undetectable		 3fl9H-1jgsA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1jgs MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR
(Escherichia
coli) 		3 / 3 LEU A  60
LEU A  75
ARG A  94
 None
SAL  A 256 ( 4.6A)
None
 0.62A 5hnzB-1jgsA:
undetectable		 5hnzB-1jgsA:
14.57