SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jhg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CEO_A_T44A1395_1 (THYROXINE-BINDING GLOBULIN)	1jhg	TRP OPERON REPRESSOR (Escherichia coli)	5 / 11	LEU A 100 SER A 86 LEU A 89 LYS A 90 LEU A 62	None	1.06A	2ceoA-1jhgA: undetectable	2ceoA-1jhgA: 18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NSI_A_H4BA600_1 (PROTEIN (NITRIC OXIDE SYNTHASE))	1jhg	TRP OPERON REPRESSOR (Escherichia coli)	4 / 7	MET A 66 ARG A 56 ILE A 82 GLU A 70	None	1.27A	2nsiA-1jhgA: undetectable 2nsiB-1jhgA: undetectable	2nsiA-1jhgA: 12.56 2nsiB-1jhgA: 12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NSI_B_H4BB601_1 (PROTEIN (NITRIC OXIDE SYNTHASE))	1jhg	TRP OPERON REPRESSOR (Escherichia coli)	4 / 7	GLU A 70 MET A 66 ARG A 56 ILE A 82	None	1.24A	2nsiA-1jhgA: undetectable 2nsiB-1jhgA: undetectable	2nsiA-1jhgA: 12.56 2nsiB-1jhgA: 12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NSI_C_H4BC602_1 (PROTEIN (NITRIC OXIDE SYNTHASE))	1jhg	TRP OPERON REPRESSOR (Escherichia coli)	4 / 7	MET A 66 ARG A 56 ILE A 82 GLU A 70	None	1.27A	2nsiC-1jhgA: undetectable 2nsiD-1jhgA: undetectable	2nsiC-1jhgA: 12.56 2nsiD-1jhgA: 12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NSI_D_H4BD603_1 (PROTEIN (NITRIC OXIDE SYNTHASE))	1jhg	TRP OPERON REPRESSOR (Escherichia coli)	4 / 7	GLU A 70 MET A 66 ARG A 56 ILE A 82	None	1.27A	2nsiC-1jhgA: undetectable 2nsiD-1jhgA: undetectable	2nsiC-1jhgA: 12.56 2nsiD-1jhgA: 12.56

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2CEO_A_T44A1395_1","THYROXINE-BINDING GLOBULIN","1jhg","TRP OPERON REPRESSOR","Escherichia coli",5,"LEU A 100;SER A  86;LEU A  89;LYS A  90;LEU A  62","None","1.06A","2ceoA-1jhgA:undetectable","2ceoA-1jhgA:18.10"],["2NSI_A_H4BA600_1","PROTEIN (NITRIC OXIDE SYNTHASE);PROTEIN (NITRIC OXIDE SYNTHASE)","1jhg","TRP OPERON REPRESSOR","Escherichia coli",4,"MET A  66;ARG A  56;ILE A  82;GLU A  70","None","1.27A","2nsiA-1jhgA:undetectable;2nsiB-1jhgA:undetectable","2nsiA-1jhgA:12.56;2nsiB-1jhgA:12.56"],["2NSI_B_H4BB601_1","PROTEIN (NITRIC OXIDE SYNTHASE);PROTEIN (NITRIC OXIDE SYNTHASE)","1jhg","TRP OPERON REPRESSOR","Escherichia coli",4,"GLU A  70;MET A  66;ARG A  56;ILE A  82","None","1.24A","2nsiA-1jhgA:undetectable;2nsiB-1jhgA:undetectable","2nsiA-1jhgA:12.56;2nsiB-1jhgA:12.56"],["2NSI_C_H4BC602_1","PROTEIN (NITRIC OXIDE SYNTHASE);PROTEIN (NITRIC OXIDE SYNTHASE)","1jhg","TRP OPERON REPRESSOR","Escherichia coli",4,"MET A  66;ARG A  56;ILE A  82;GLU A  70","None","1.27A","2nsiC-1jhgA:undetectable;2nsiD-1jhgA:undetectable","2nsiC-1jhgA:12.56;2nsiD-1jhgA:12.56"],["2NSI_D_H4BD603_1","PROTEIN (NITRIC OXIDE SYNTHASE);PROTEIN (NITRIC OXIDE SYNTHASE)","1jhg","TRP OPERON REPRESSOR","Escherichia coli",4,"GLU A  70;MET A  66;ARG A  56;ILE A  82","None","1.27A","2nsiC-1jhgA:undetectable;2nsiD-1jhgA:undetectable","2nsiC-1jhgA:12.56;2nsiD-1jhgA:12.56"]]