SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jhz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 8 GLY A 246
GLY A 199
PHE A 200
GLY A 195
 None
 0.64A 1d0vA-1jhzA:
undetectable		 1d0vA-1jhzA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 8 GLY A 246
GLY A 199
PHE A 200
GLY A 195
 None
 0.67A 1jhaA-1jhzA:
undetectable		 1jhaA-1jhzA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 8 GLY A 246
GLY A 199
PHE A 200
GLY A 195
 None
 0.67A 1jhqA-1jhzA:
undetectable		 1jhqA-1jhzA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 8 GLY A 246
GLY A 199
PHE A 200
GLY A 195
 None
 0.66A 1jhvA-1jhzA:
undetectable		 1jhvA-1jhzA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 12 ALA A 251
GLY A 246
ILE A 249
ILE A 272
PHE A 283
 None
 1.16A 1ve3A-1jhzA:
undetectable		 1ve3A-1jhzA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 12 ALA A  72
GLY A 246
PRO A 187
ILE A 272
LEU A 287
 None
 1.01A 2plwA-1jhzA:
undetectable		 2plwA-1jhzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 7 ILE A 174
GLY A 170
PHE A 200
ILE A 181
 None
 0.84A 2y7wC-1jhzA:
1.0		 2y7wC-1jhzA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 8 ALA A 157
ILE A 159
ILE A 319
HIS A 322
 None
 0.88A 2zm8A-1jhzA:
undetectable		 2zm8A-1jhzA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 8 ALA A 157
ILE A 159
ILE A 319
HIS A 322
 None
 0.88A 2zmaA-1jhzA:
undetectable		 2zmaA-1jhzA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 8 LEU A 305
ILE A  62
GLY A  89
LYS A  88
 None
 0.92A 3b9lA-1jhzA:
0.0		 3b9lA-1jhzA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 12 TYR A 126
ILE A 140
ILE A 309
LEU A 120
VAL A 116
 None
 1.24A 3fpjB-1jhzA:
3.8		 3fpjB-1jhzA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 12 PHE A 244
GLY A 166
GLY A 170
ALA A 203
GLY A 199
 None
 1.08A 3tegA-1jhzA:
undetectable		 3tegA-1jhzA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		3 / 3 ASN A 276
ALA A 280
ARG A 328
 None
 0.89A 3tj7C-1jhzA:
0.0
3tj7D-1jhzA:
0.0		 3tj7C-1jhzA:
21.45
3tj7D-1jhzA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 7 ARG A 239
GLY A 253
VAL A 269
VAL A 243
 None
 0.77A 3ufnB-1jhzA:
undetectable		 3ufnB-1jhzA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 8 GLY A 170
LEU A 173
ILE A 174
ILE A 209
 None
 0.82A 4em2A-1jhzA:
undetectable		 4em2A-1jhzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 9 GLY A 246
GLY A 199
PHE A 200
LEU A 197
GLY A 195
 None
 1.18A 4kqiA-1jhzA:
undetectable		 4kqiA-1jhzA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		5 / 12 VAL A 183
GLY A 186
PHE A 244
GLY A 273
ASP A 275
 None
 1.36A 4pevB-1jhzA:
15.0		 4pevB-1jhzA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 6 ASN A 276
PRO A 323
ASP A 248
TYR A 274
 None
 1.06A 5umd2-1jhzA:
undetectable
5umdF-1jhzA:
undetectable		 5umd2-1jhzA:
12.46
5umdF-1jhzA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 4 PRO A 266
MET A 230
GLY A 226
VAL A 243
 None
 1.32A 6ak3A-1jhzA:
0.0		 6ak3A-1jhzA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR
(Escherichia
coli) 		4 / 7 ASP A 275
GLN A 292
GLY A 186
GLY A 246
 None
 0.92A 6ekzA-1jhzA:
undetectable		 6ekzA-1jhzA:
16.90