SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jig'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 1jig DLP-2
(Bacillus
anthracis) 		5 / 10 LYS A  13
LEU A  21
GLU A 111
ALA A 104
LEU A 135
 None
 1.19A 1ie4A-1jigA:
undetectable
1ie4C-1jigA:
undetectable		 1ie4A-1jigA:
24.20
1ie4C-1jigA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 1jig DLP-2
(Bacillus
anthracis) 		4 / 5 GLN A 137
THR A 133
GLU A  50
THR A  53
 None
 1.42A 3glqB-1jigA:
undetectable		 3glqB-1jigA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 1jig DLP-2
(Bacillus
anthracis) 		4 / 6 PRO A  69
GLY A  67
LEU A  65
GLU A  60
 None
None
None
FE  A 402 (-2.4A)
 0.98A 3zqtA-1jigA:
undetectable		 3zqtA-1jigA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1jig DLP-2
(Bacillus
anthracis) 		5 / 12 PHE A  47
GLY A  52
TYR A  76
LYS A  24
ALA A  16
 None
 1.26A 4eb4A-1jigA:
undetectable		 4eb4A-1jigA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1jig DLP-2
(Bacillus
anthracis) 		4 / 6 LEU A  21
TYR A  54
LEU A 105
TYR A 102
 None
 1.01A 4f3tA-1jigA:
undetectable		 4f3tA-1jigA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 1jig DLP-2
(Bacillus
anthracis) 		3 / 3 LEU A  98
ASP A 101
TYR A 102
 None
 0.24A 4qc6B-1jigA:
undetectable		 4qc6B-1jigA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1jig DLP-2
(Bacillus
anthracis) 		4 / 7 LEU A  21
TYR A  54
LEU A 105
TYR A 102
 None
 1.04A 4z4fA-1jigA:
undetectable		 4z4fA-1jigA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 1jig DLP-2
(Bacillus
anthracis) 		5 / 11 LEU A 142
VAL A  99
LEU A  21
SER A 103
LEU A 135
 None
 1.16A 4zbqA-1jigA:
undetectable		 4zbqA-1jigA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1jig DLP-2
(Bacillus
anthracis) 		4 / 5 LEU A  21
TYR A  54
LEU A 105
TYR A 102
 None
 1.01A 5ki6A-1jigA:
undetectable		 5ki6A-1jigA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1jig DLP-2
(Bacillus
anthracis) 		4 / 7 LEU A  21
TYR A  54
LEU A 105
TYR A 102
 None
 1.00A 5t7bA-1jigA:
undetectable		 5t7bA-1jigA:
10.64