SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jik'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 9 LEU A   9
ILE A  15
LEU A  35
GLY A 218
LEU A  28
 None
 1.16A 1e7aB-1jikA:
undetectable		 1e7aB-1jikA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 8 PHE A 111
ILE A 110
PHE A 273
LEU A  57
 None
 0.91A 1fslA-1jikA:
undetectable		 1fslA-1jikA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		6 / 11 GLY A  38
HIS A  50
GLY A 193
ASP A 195
GLN A 196
LEU A 223
 545  A 421 (-4.2A)
545  A 421 (-3.7A)
545  A 421 (-3.6A)
545  A 421 (-2.9A)
545  A 421 (-3.4A)
None
 0.96A 1jzsA-1jikA:
2.0		 1jzsA-1jikA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 HIS A  47
GLY A  49
HIS A  50
GLY A 193
ASP A 195
 None
None
545  A 421 (-3.7A)
545  A 421 (-3.6A)
545  A 421 (-2.9A)
 0.52A 1pg2A-1jikA:
9.3		 1pg2A-1jikA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 GLY A  49
HIS A  50
ASP A 195
GLN A 196
VAL A 224
 None
545  A 421 (-3.7A)
545  A 421 (-2.9A)
545  A 421 (-3.4A)
None
 1.08A 1qu2A-1jikA:
5.1		 1qu2A-1jikA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 HIS A  50
GLY A 193
ASP A 195
GLN A 196
VAL A 224
 545  A 421 (-3.7A)
545  A 421 (-3.6A)
545  A 421 (-2.9A)
545  A 421 (-3.4A)
None
 0.60A 1qu2A-1jikA:
5.1		 1qu2A-1jikA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 LEU A  46
GLY A  38
ASP A  80
GLY A 193
ILE A 221
 545  A 421 ( 3.9A)
545  A 421 (-4.2A)
545  A 421 (-3.4A)
545  A 421 (-3.6A)
None
 0.90A 2ienA-1jikA:
undetectable		 2ienA-1jikA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 6 ALA A  43
ASP A  44
TRP A 241
ARG A  88
 545  A 421 ( 4.7A)
None
None
None
 1.40A 2ouzA-1jikA:
undetectable		 2ouzA-1jikA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 7 ASP A 263
VAL A 264
ALA A 295
PHE A 232
 None
 1.05A 2q6oA-1jikA:
undetectable		 2q6oA-1jikA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 8 PHE A 111
LEU A  46
LEU A 242
LEU A  55
PHE A 306
 None
545  A 421 ( 3.9A)
None
None
None
 1.36A 2vcvF-1jikA:
undetectable		 2vcvF-1jikA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 HIS A  47
GLY A  49
HIS A  50
GLY A 193
ASP A 195
 None
None
545  A 421 (-3.7A)
545  A 421 (-3.6A)
545  A 421 (-2.9A)
 0.76A 2x1lA-1jikA:
9.3		 2x1lA-1jikA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 HIS A  47
GLY A  49
HIS A  50
GLY A 193
ASP A 195
 None
None
545  A 421 (-3.7A)
545  A 421 (-3.6A)
545  A 421 (-2.9A)
 0.77A 2x1lB-1jikA:
9.2		 2x1lB-1jikA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 HIS A  47
GLY A  49
HIS A  50
GLY A 193
ASP A 195
 None
None
545  A 421 (-3.7A)
545  A 421 (-3.6A)
545  A 421 (-2.9A)
 0.81A 2x1lC-1jikA:
9.2		 2x1lC-1jikA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 LEU A 173
ALA A 175
ILE A 176
VAL A 144
PHE A 136
 None
 0.87A 3b2rA-1jikA:
undetectable		 3b2rA-1jikA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 LEU A 173
ALA A 175
ILE A 176
VAL A 144
PHE A 136
 None
 0.88A 3b2rB-1jikA:
undetectable		 3b2rB-1jikA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 6 VAL A 120
GLN A  61
ARG A  59
LEU A   9
 None
 1.03A 3bjwE-1jikA:
undetectable		 3bjwE-1jikA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 6 GLY A  72
GLY A  76
MET A  77
ASN A 123
 545  A 421 ( 4.8A)
None
None
None
 0.92A 3e9rA-1jikA:
undetectable		 3e9rA-1jikA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 6 GLY A  72
GLY A  76
MET A  77
ASN A 123
 545  A 421 ( 4.8A)
None
None
None
 0.91A 3e9rC-1jikA:
undetectable		 3e9rC-1jikA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 9 LEU A  46
GLY A  38
ASP A  80
GLY A 193
ILE A 221
 545  A 421 ( 3.9A)
545  A 421 (-4.2A)
545  A 421 (-3.4A)
545  A 421 (-3.6A)
None
 0.94A 3ektA-1jikA:
undetectable		 3ektA-1jikA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 6 LEU A  27
GLN A  32
LEU A  28
GLU A  31
 None
 1.11A 3h5gB-1jikA:
undetectable
3h5gC-1jikA:
undetectable		 3h5gB-1jikA:
4.05
3h5gC-1jikA:
4.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IIZ_A_SAMA1501_0
(BIOTIN SYNTHETASE,
PUTATIVE)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 TYR A  36
CYH A  37
SER A  82
GLY A 198
ILE A  71
 None
545  A 421 ( 4.2A)
None
None
None
 1.21A 3iizA-1jikA:
1.4		 3iizA-1jikA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 8 ASP A 177
LEU A  70
ASP A  40
ASP A  80
 545  A 421 (-3.3A)
545  A 421 (-4.3A)
545  A 421 (-3.7A)
545  A 421 (-3.4A)
 1.26A 3n2oC-1jikA:
undetectable
3n2oD-1jikA:
undetectable		 3n2oC-1jikA:
22.88
3n2oD-1jikA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 GLN A 196
GLY A 198
GLY A  83
SER A 154
SER A 164
 545  A 421 (-3.4A)
None
None
None
None
 1.20A 3sueD-1jikA:
undetectable		 3sueD-1jikA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 9 PHE A  60
LEU A 219
THR A  19
LEU A  35
ILE A 189
 None
 1.20A 3tbgD-1jikA:
0.0		 3tbgD-1jikA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 ASN A 124
TRP A 127
ASP A  40
 545  A 421 (-4.4A)
None
545  A 421 (-3.7A)
 0.87A 4a7tA-1jikA:
undetectable
4a7tF-1jikA:
undetectable		 4a7tA-1jikA:
16.67
4a7tF-1jikA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 LYS A 305
THR A 304
ILE A 257
 None
 0.92A 4e0fB-1jikA:
0.0		 4e0fB-1jikA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 HIS A 108
SER A 104
TRP A 127
LEU A 128
GLY A  38
 None
None
None
None
545  A 421 (-4.2A)
 1.28A 4fogA-1jikA:
0.2		 4fogA-1jikA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JXC_A_SAMA402_0
(FEFE-HYDROGENASE
MATURASE)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 TYR A  36
CYH A  37
SER A  82
GLY A 198
ILE A  71
 None
545  A 421 ( 4.2A)
None
None
None
 1.20A 4jxcA-1jikA:
1.0		 4jxcA-1jikA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FEP_A_SAMA407_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 TYR A  36
CYH A  37
SER A  82
GLY A 198
ILE A  71
 None
545  A 421 ( 4.2A)
None
None
None
 1.17A 5fepA-1jikA:
1.5		 5fepA-1jikA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 TYR A  36
CYH A  37
SER A  82
GLY A 198
ILE A  71
 None
545  A 421 ( 4.2A)
None
None
None
 1.19A 5fesA-1jikA:
1.5		 5fesA-1jikA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 7 ILE A 200
GLY A 198
LEU A 128
CYH A  37
ASP A  80
 None
None
None
545  A 421 ( 4.2A)
545  A 421 (-3.4A)
 1.31A 5hieB-1jikA:
undetectable		 5hieB-1jikA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 LEU A  51
LEU A 274
ILE A 265
THR A 304
ALA A 300
 None
 1.37A 5ienA-1jikA:
0.0		 5ienA-1jikA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 1jik TYROSYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 9 ILE A  71
ALA A  39
GLY A  38
GLY A  79
TYR A 170
 None
545  A 421 (-4.1A)
545  A 421 (-4.2A)
None
545  A 421 (-4.6A)
 1.14A 6nm4B-1jikA:
0.0		 6nm4B-1jikA:
18.27