SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jio'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  99
THR A  97
PRO A  95
 None
 0.77A 1a7yA-1jioA:
undetectable		 1a7yA-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  97
PRO A  95
THR A  99
 None
 0.82A 1a7yB-1jioA:
undetectable		 1a7yB-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  99
THR A  97
PRO A  95
 None
 0.81A 1a7yB-1jioA:
undetectable		 1a7yB-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  97
PRO A  95
THR A  99
 None
 0.95A 1dscC-1jioA:
undetectable		 1dscC-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  99
THR A  97
PRO A  95
 None
 0.78A 1dscC-1jioA:
undetectable		 1dscC-1jioA:
7.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		7 / 8 TYR A  75
PHE A  86
ILE A 174
LEU A 175
LEU A 240
GLU A 244
LEU A 391
 DEB  A 420 ( 4.8A)
None
DEB  A 420 (-4.8A)
None
DEB  A 420 ( 4.5A)
None
DEB  A 420 ( 4.8A)
 0.59A 1eupA-1jioA:
69.4		 1eupA-1jioA:
98.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		6 / 8 TYR A  75
PHE A  86
SER A 171
ILE A 174
LEU A 240
GLU A 244
 DEB  A 420 ( 4.8A)
None
DEB  A 420 ( 4.8A)
DEB  A 420 (-4.8A)
DEB  A 420 ( 4.5A)
None
 0.75A 1eupA-1jioA:
69.4		 1eupA-1jioA:
98.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  99
THR A  97
PRO A  95
 None
 0.72A 1fjaC-1jioA:
undetectable		 1fjaC-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  99
THR A  97
PRO A  95
 None
 0.72A 1fjaD-1jioA:
undetectable		 1fjaD-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  97
PRO A  95
THR A  99
 None
 0.78A 1i3wE-1jioA:
undetectable		 1i3wE-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  99
THR A  97
PRO A  95
 None
 0.77A 1i3wE-1jioA:
undetectable		 1i3wE-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  99
THR A  97
PRO A  95
 None
 0.78A 1i3wF-1jioA:
undetectable		 1i3wF-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  97
PRO A  95
THR A  99
 None
 0.77A 1i3wG-1jioA:
undetectable		 1i3wG-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  99
THR A  97
PRO A  95
 None
 0.76A 1i3wG-1jioA:
undetectable		 1i3wG-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  99
THR A  97
PRO A  95
 None
 0.78A 1i3wH-1jioA:
undetectable		 1i3wH-1jioA:
7.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		5 / 11 PHE A  72
ALA A  74
ALA A 245
THR A 292
LEU A 391
 None
DEB  A 420 (-3.8A)
HEM  A 410 (-3.5A)
None
DEB  A 420 ( 4.8A)
 1.02A 1jinA-1jioA:
68.3		 1jinA-1jioA:
98.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		6 / 11 PHE A  72
ALA A  74
TYR A  75
LEU A 240
THR A 292
LEU A 391
 None
DEB  A 420 (-3.8A)
DEB  A 420 ( 4.8A)
DEB  A 420 ( 4.5A)
None
DEB  A 420 ( 4.8A)
 0.93A 1jinA-1jioA:
68.3		 1jinA-1jioA:
98.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		10 / 11 SER A  59
ALA A  74
TYR A  75
THR A  92
VAL A 237
LEU A 240
ALA A 241
ALA A 245
THR A 292
LEU A 391
 HEM  A 410 ( 4.9A)
DEB  A 420 (-3.8A)
DEB  A 420 ( 4.8A)
DEB  A 420 (-4.2A)
DEB  A 420 ( 4.3A)
DEB  A 420 ( 4.5A)
DEB  A 420 ( 3.6A)
HEM  A 410 (-3.5A)
None
DEB  A 420 ( 4.8A)
 0.69A 1jinA-1jioA:
68.3		 1jinA-1jioA:
98.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		7 / 12 ALA A  74
GLY A  91
LEU A 175
ARG A 185
VAL A 237
ALA A 241
LEU A 391
 DEB  A 420 (-3.8A)
HEM  A 410 ( 3.1A)
None
DEB  A 420 ( 4.6A)
DEB  A 420 ( 4.3A)
DEB  A 420 ( 3.6A)
DEB  A 420 ( 4.8A)
 0.51A 1jipA-1jioA:
68.9		 1jipA-1jioA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		6 / 12 ALA A  74
LEU A 175
ARG A 185
ALA A 245
THR A 292
LEU A 391
 DEB  A 420 (-3.8A)
None
DEB  A 420 ( 4.6A)
HEM  A 410 (-3.5A)
None
DEB  A 420 ( 4.8A)
 1.26A 1jipA-1jioA:
68.9		 1jipA-1jioA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		9 / 12 ALA A  74
TYR A  75
GLY A  91
THR A  92
LEU A 175
ARG A 185
VAL A 237
THR A 292
LEU A 391
 DEB  A 420 (-3.8A)
DEB  A 420 ( 4.8A)
HEM  A 410 ( 3.1A)
DEB  A 420 (-4.2A)
None
DEB  A 420 ( 4.6A)
DEB  A 420 ( 4.3A)
None
DEB  A 420 ( 4.8A)
 0.21A 1jipA-1jioA:
68.9		 1jipA-1jioA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		5 / 12 ALA A  74
TYR A  75
LEU A 392
VAL A 237
LEU A 391
 DEB  A 420 (-3.8A)
DEB  A 420 ( 4.8A)
DEB  A 420 (-3.6A)
DEB  A 420 ( 4.3A)
DEB  A 420 ( 4.8A)
 1.29A 1jipA-1jioA:
68.9		 1jipA-1jioA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		7 / 12 GLY A  91
LEU A 175
ARG A 185
VAL A 237
LEU A 240
ALA A 241
LEU A 391
 HEM  A 410 ( 3.1A)
None
DEB  A 420 ( 4.6A)
DEB  A 420 ( 4.3A)
DEB  A 420 ( 4.5A)
DEB  A 420 ( 3.6A)
DEB  A 420 ( 4.8A)
 0.69A 1jipA-1jioA:
68.9		 1jipA-1jioA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		6 / 12 PHE A  72
ALA A  74
LEU A 175
ARG A 185
ALA A 245
LEU A 391
 None
DEB  A 420 (-3.8A)
None
DEB  A 420 ( 4.6A)
HEM  A 410 (-3.5A)
DEB  A 420 ( 4.8A)
 1.29A 1jipA-1jioA:
68.9		 1jipA-1jioA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		6 / 12 PHE A  72
ALA A  74
TYR A  75
LEU A 175
ARG A 185
LEU A 391
 None
DEB  A 420 (-3.8A)
DEB  A 420 ( 4.8A)
None
DEB  A 420 ( 4.6A)
DEB  A 420 ( 4.8A)
 0.75A 1jipA-1jioA:
68.9		 1jipA-1jioA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		6 / 12 PHE A  72
TYR A  75
LEU A 175
ARG A 185
LEU A 240
LEU A 391
 None
DEB  A 420 ( 4.8A)
None
DEB  A 420 ( 4.6A)
DEB  A 420 ( 4.5A)
DEB  A 420 ( 4.8A)
 0.76A 1jipA-1jioA:
68.9		 1jipA-1jioA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		8 / 12 TYR A  75
GLY A  91
THR A  92
LEU A 175
ARG A 185
VAL A 237
LEU A 240
LEU A 391
 DEB  A 420 ( 4.8A)
HEM  A 410 ( 3.1A)
DEB  A 420 (-4.2A)
None
DEB  A 420 ( 4.6A)
DEB  A 420 ( 4.3A)
DEB  A 420 ( 4.5A)
DEB  A 420 ( 4.8A)
 0.43A 1jipA-1jioA:
68.9		 1jipA-1jioA:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  97
PRO A  95
THR A  99
 None
 0.81A 1mnvD-1jioA:
undetectable		 1mnvD-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  99
THR A  97
PRO A  95
 None
 0.74A 1mnvD-1jioA:
undetectable		 1mnvD-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 PHE A 195
TRP A 170
GLU A 191
 None
 1.19A 1mogA-1jioA:
undetectable		 1mogA-1jioA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  97
PRO A  95
THR A  99
 None
 0.81A 1ovfB-1jioA:
undetectable		 1ovfB-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		5 / 11 THR A 125
LEU A 359
VAL A 363
GLY A 361
ILE A 124
 None
 1.11A 1phgA-1jioA:
42.2		 1phgA-1jioA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  99
THR A  97
PRO A  95
 None
 0.79A 1qfiA-1jioA:
undetectable		 1qfiA-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  99
THR A  97
PRO A  95
 None
 0.81A 1qfiB-1jioA:
undetectable		 1qfiB-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  97
PRO A  95
THR A  99
 None
 0.85A 1unjF-1jioA:
undetectable		 1unjF-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  99
THR A  97
PRO A  95
 None
 0.83A 1unjF-1jioA:
undetectable		 1unjF-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  97
PRO A  95
THR A  99
 None
 0.80A 1unjL-1jioA:
undetectable		 1unjL-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  99
THR A  97
PRO A  95
 None
 0.79A 1unjL-1jioA:
undetectable		 1unjL-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  97
PRO A  95
THR A  99
 None
 0.84A 1unjR-1jioA:
undetectable		 1unjR-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  99
THR A  97
PRO A  95
 None
 0.79A 1unjR-1jioA:
undetectable		 1unjR-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  99
THR A  97
PRO A  95
 None
 0.79A 1unjW-1jioA:
undetectable		 1unjW-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  97
PRO A  95
THR A  99
 None
 0.80A 1unjX-1jioA:
undetectable		 1unjX-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  99
THR A  97
PRO A  95
 None
 0.79A 1unjX-1jioA:
undetectable		 1unjX-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  97
PRO A  95
THR A  99
 None
 0.78A 1unmE-1jioA:
undetectable		 1unmE-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  99
THR A  97
PRO A  95
 None
 0.76A 1unmE-1jioA:
undetectable		 1unmE-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  97
PRO A  95
THR A  99
 None
 0.77A 1unmF-1jioA:
undetectable		 1unmF-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  99
THR A  97
PRO A  95
 None
 0.74A 1unmF-1jioA:
undetectable		 1unmF-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  99
THR A  97
PRO A  95
 None
 0.72A 209dC-1jioA:
undetectable		 209dC-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTU_A_BCZA801_0
(NEURAMINIDASE)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		5 / 12 GLU A 244
LEU A 392
ARG A 387
ILE A 250
GLU A 360
 None
DEB  A 420 (-3.6A)
None
None
None
 1.50A 2htuA-1jioA:
undetectable		 2htuA-1jioA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		5 / 10 LEU A 199
ALA A 235
VAL A 159
SER A 171
PHE A 195
 None
None
None
DEB  A 420 ( 4.8A)
None
 1.12A 2w9gA-1jioA:
undetectable		 2w9gA-1jioA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		5 / 11 ILE A 285
PHE A 332
GLY A 253
PRO A 287
ILE A 281
 None
None
None
HEM  A 410 ( 4.8A)
None
 1.15A 2y7kA-1jioA:
undetectable		 2y7kA-1jioA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		5 / 12 ALA A 286
GLY A 253
THR A 254
LEU A 282
VAL A 278
 None
 1.17A 2zifA-1jioA:
undetectable		 2zifA-1jioA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		5 / 12 ALA A 286
GLY A 253
THR A 254
LEU A 282
VAL A 278
 None
 1.17A 2zifB-1jioA:
undetectable		 2zifB-1jioA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  97
PRO A  95
THR A  99
 None
 0.87A 316dC-1jioA:
undetectable		 316dC-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		5 / 11 LEU A 199
ALA A 235
VAL A 159
SER A 171
PHE A 195
 None
None
None
DEB  A 420 ( 4.8A)
None
 1.08A 3frbX-1jioA:
undetectable		 3frbX-1jioA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		5 / 12 VAL A 152
ALA A 126
VAL A 363
GLY A 361
LEU A 356
 None
None
None
None
HEM  A 410 ( 4.4A)
 1.02A 3ln1A-1jioA:
0.0		 3ln1A-1jioA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		5 / 12 VAL A 152
ALA A 126
VAL A 363
GLY A 361
LEU A 356
 None
None
None
None
HEM  A 410 ( 4.4A)
 1.00A 3ln1B-1jioA:
0.4		 3ln1B-1jioA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		5 / 12 VAL A 152
ALA A 126
VAL A 363
GLY A 361
LEU A 356
 None
None
None
None
HEM  A 410 ( 4.4A)
 1.01A 3ln1C-1jioA:
1.7		 3ln1C-1jioA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		5 / 12 VAL A 152
ALA A 126
VAL A 363
GLY A 361
LEU A 356
 None
None
None
None
HEM  A 410 ( 4.4A)
 1.01A 3ln1D-1jioA:
0.0		 3ln1D-1jioA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		5 / 12 ALA A  27
ILE A 306
PRO A 307
SER A 310
THR A  26
 None
 1.09A 3nrrA-1jioA:
undetectable		 3nrrA-1jioA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		5 / 12 ALA A  27
ILE A 306
PRO A 307
SER A 310
THR A  26
 None
 1.09A 3nrrB-1jioA:
undetectable		 3nrrB-1jioA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		5 / 12 PHE A 369
LEU A 368
GLY A 378
LEU A 377
ALA A 374
 None
 0.99A 3tbgB-1jioA:
32.0		 3tbgB-1jioA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		5 / 12 PHE A 369
LEU A 368
GLY A 378
LEU A 377
ALA A 374
 None
 1.02A 3tbgD-1jioA:
31.9		 3tbgD-1jioA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 ARG A 185
PHE A  78
PRO A  79
 DEB  A 420 ( 4.6A)
None
None
 0.63A 3zoaB-1jioA:
undetectable		 3zoaB-1jioA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		4 / 6 LEU A 249
LYS A 358
LEU A 282
GLU A 279
 HEM  A 410 ( 4.3A)
None
None
None
 1.15A 4f3tA-1jioA:
undetectable		 4f3tA-1jioA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 ARG A 321
HIS A 330
TYR A 284
 None
 1.08A 4fu8A-1jioA:
0.0		 4fu8A-1jioA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 ARG A 321
HIS A 330
TYR A 284
 None
 1.19A 4fu9A-1jioA:
undetectable		 4fu9A-1jioA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  97
PRO A  95
THR A  99
 None
 0.83A 4hivD-1jioA:
undetectable		 4hivD-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 ASP A 142
GLU A 131
SER A 172
 None
 0.86A 5bw4B-1jioA:
undetectable		 5bw4B-1jioA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 PHE A 144
ILE A 250
ASP A 396
 None
 0.73A 5cswB-1jioA:
undetectable		 5cswB-1jioA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		5 / 12 VAL A 152
ALA A 126
VAL A 363
GLY A 361
LEU A 356
 None
None
None
None
HEM  A 410 ( 4.4A)
 0.99A 5jw1A-1jioA:
undetectable		 5jw1A-1jioA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		5 / 12 VAL A 152
ALA A 126
VAL A 363
GLY A 361
LEU A 356
 None
None
None
None
HEM  A 410 ( 4.4A)
 1.04A 5kirA-1jioA:
undetectable		 5kirA-1jioA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		5 / 12 VAL A 152
ALA A 126
VAL A 363
GLY A 361
LEU A 356
 None
None
None
None
HEM  A 410 ( 4.4A)
 1.12A 5kirB-1jioA:
0.0		 5kirB-1jioA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		4 / 5 TYR A  20
ASP A 322
PRO A 323
ALA A 319
 None
 0.99A 5otrA-1jioA:
undetectable		 5otrA-1jioA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		4 / 5 LEU A 249
LYS A 358
LEU A 282
GLU A 279
 HEM  A 410 ( 4.3A)
None
None
None
 0.96A 5weaA-1jioA:
undetectable		 5weaA-1jioA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		5 / 12 ILE A 285
GLY A 253
LEU A 377
VAL A 384
ILE A 395
 None
 1.04A 5ycnA-1jioA:
0.0		 5ycnA-1jioA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 TYR A  45
ALA A  51
LEU A  52
 None
 0.64A 6ag0C-1jioA:
undetectable		 6ag0C-1jioA:
10.70