SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1jjo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 1jjo NEUROSERPIN
(Mus
musculus) 		5 / 12 LEU C 288
PHE E 370
ASN A  49
LEU A  51
TYR C 244
 None
 1.09A 1u72A-1jjoC:
undetectable		 1u72A-1jjoC:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1jjo NEUROSERPIN
(Mus
musculus) 		5 / 12 LEU C 288
GLU C 343
GLY C 344
ASN C 341
ALA C 347
 None
 0.93A 2bm9E-1jjoC:
undetectable		 2bm9E-1jjoC:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 1jjo NEUROSERPIN
NEUROSERPIN
(Mus
musculus;
Mus
musculus) 		5 / 12 ARG C 290
PHE C 291
ILE C 338
ILE E 374
GLU C 342
 None
 1.09A 2j0dA-1jjoC:
0.0		 2j0dA-1jjoC:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1jjo NEUROSERPIN
(Mus
musculus) 		4 / 5 LEU E 383
ALA C 347
ILE C 338
SER C 345
 None
 1.17A 2othA-1jjoE:
undetectable		 2othA-1jjoE:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 1jjo NEUROSERPIN
NEUROSERPIN
NEUROSERPIN
(Mus
musculus;
Mus
musculus;
Mus
musculus) 		5 / 12 LEU C 288
PHE E 370
ASN A  49
LEU A  51
TYR C 244
 None
 1.07A 2w3mA-1jjoC:
undetectable		 2w3mA-1jjoC:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 1jjo NEUROSERPIN
(Mus
musculus) 		4 / 5 PHE E 384
ILE C 297
ASN C 166
PHE A  52
 None
 1.24A 3octA-1jjoE:
undetectable		 3octA-1jjoE:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1jjo NEUROSERPIN
(Mus
musculus) 		4 / 7 PHE C 178
VAL C 333
ASP C 177
ILE C 354
 None
 0.76A 5ik1A-1jjoC:
undetectable		 5ik1A-1jjoC:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 1jjo NEUROSERPIN
NEUROSERPIN
(Mus
musculus;
Mus
musculus) 		5 / 12 ILE C 297
SER A  34
HIS A  40
LEU C 299
LEU C 306
 None
 1.17A 6chgC-1jjoC:
undetectable		 6chgC-1jjoC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1jjo NEUROSERPIN
(Mus
musculus) 		3 / 3 LEU C 131
ASN C 181
LEU C 184
 None
 0.59A 6exiA-1jjoC:
undetectable		 6exiA-1jjoC:
16.94